Association of CTLA4 gene polymorphisms with lymphatic filariasis in an East Malaysian population.
Identifieur interne : 004295 ( Ncbi/Merge ); précédent : 004294; suivant : 004296Association of CTLA4 gene polymorphisms with lymphatic filariasis in an East Malaysian population.
Auteurs : Zulkarnain Md Idris [Malaisie] ; Noorizan Miswan ; Jamail Muhi ; Tajul Ariffin Awang Mohd ; Jürgen F J. Kun ; Rahmah NoordinSource :
- Human immunology [ 1879-1166 ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Allèles, Antigène CTLA-4, Antigènes CD (génétique), Enfant, Enfant d'âge préscolaire, Exons, Femelle, Filariose lymphatique (génétique), Fréquence d'allèle, Génotype, Humains, Jeune adulte, Malaisie, Mâle, Polymorphisme de nucléotide simple (génétique), Population d'origine asiatique (génétique), Prédisposition génétique à une maladie, Régions promotrices (génétique) (génétique), Sujet âgé, Études cas-témoins.
- MESH :
- génétique : Antigènes CD, Filariose lymphatique, Polymorphisme de nucléotide simple, Population d'origine asiatique, Régions promotrices (génétique).
- Adolescent, Adulte, Adulte d'âge moyen, Allèles, Antigène CTLA-4, Enfant, Enfant d'âge préscolaire, Exons, Femelle, Fréquence d'allèle, Génotype, Humains, Jeune adulte, Malaisie, Mâle, Prédisposition génétique à une maladie, Sujet âgé, Études cas-témoins.
- Wicri :
- geographic : Malaisie.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Alleles, Antigens, CD (genetics), Asian Continental Ancestry Group (genetics), CTLA-4 Antigen, Case-Control Studies, Child, Child, Preschool, Elephantiasis, Filarial (genetics), Exons, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Malaysia, Male, Middle Aged, Polymorphism, Single Nucleotide (genetics), Promoter Regions, Genetic (genetics), Young Adult.
- MESH :
- chemical , genetics : Antigens, CD.
- geographic : Malaysia.
- genetics : Asian Continental Ancestry Group, Elephantiasis, Filarial, Polymorphism, Single Nucleotide, Promoter Regions, Genetic.
- Adolescent, Adult, Aged, Alleles, CTLA-4 Antigen, Case-Control Studies, Child, Child, Preschool, Exons, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Young Adult.
Abstract
Lymphatic filariasis (LF) is a parasitic disease caused by threadlike worms of the Brugia and Wuchereria species that live in the human lymphatic system. Regulatory T cells (Tregs) may play a key role in the pathogenesis of LF, and cytotoxic T-lymphocyte antigen-4 (CTLA4) expressed by Tregs is a potential candidate gene because it modulates T-cell activation. A case-control study was performed to establish a potential association of 5 CTLA4 gene promoter single nucleotide polymorphisms (SNPs; rs733618, rs11571316, rs5742909, rs231775, and rs16840252) with the occurrence of LF in an East Malaysian population (320 LF-infected individuals and 150 healthy controls). Polymorphisms were evaluated using TaqMan real-time polymerase chain reaction followed by direct sequencing. LF carriers of the rs733618 AG genotypes (p = 0.02) and those with combined minor allele G carriers (AG + GG; p = 0.01) exhibited a significantly decreased risk for LF. Among the asymptomatic amicrofilaremic cases, positive associations were reported for all genotypes and variants of rs733618 with odds ratios (ORs) ranging from 0.27 to 0.45. In the asymptomatic microfilaremic cases, marker rs231775 exhibited a significant decreased risk, with ORs ranging from 0.50 to 0.57. The study has identified SNPs in the CTLA4 promoter gene that may be functionally linked with susceptibility to LF.
DOI: 10.1016/j.humimm.2011.03.017
PubMed: 21513760
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Kun</name></author><author><name sortKey="Noordin, Rahmah" sort="Noordin, Rahmah" uniqKey="Noordin R" first="Rahmah" last="Noordin">Rahmah Noordin</name></author></analytic><series><title level="j">Human immunology</title><idno type="eISSN">1879-1166</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Alleles</term><term>Antigens, CD (genetics)</term><term>Asian Continental Ancestry Group (genetics)</term><term>CTLA-4 Antigen</term><term>Case-Control Studies</term><term>Child</term><term>Child, Preschool</term><term>Elephantiasis, Filarial (genetics)</term><term>Exons</term><term>Female</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Malaysia</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Promoter Regions, Genetic (genetics)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Allèles</term><term>Antigène CTLA-4</term><term>Antigènes CD (génétique)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Exons</term><term>Femelle</term><term>Filariose lymphatique (génétique)</term><term>Fréquence d'allèle</term><term>Génotype</term><term>Humains</term><term>Jeune adulte</term><term>Malaisie</term><term>Mâle</term><term>Polymorphisme de nucléotide simple (génétique)</term><term>Population d'origine asiatique (génétique)</term><term>Prédisposition génétique à une maladie</term><term>Régions promotrices (génétique) (génétique)</term><term>Sujet âgé</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, CD</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Malaysia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Asian Continental Ancestry Group</term><term>Elephantiasis, Filarial</term><term>Polymorphism, Single Nucleotide</term><term>Promoter Regions, Genetic</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes CD</term><term>Filariose lymphatique</term><term>Polymorphisme de nucléotide simple</term><term>Population d'origine asiatique</term><term>Régions promotrices (génétique)</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Alleles</term><term>CTLA-4 Antigen</term><term>Case-Control Studies</term><term>Child</term><term>Child, Preschool</term><term>Exons</term><term>Female</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Allèles</term><term>Antigène CTLA-4</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Exons</term><term>Femelle</term><term>Fréquence d'allèle</term><term>Génotype</term><term>Humains</term><term>Jeune adulte</term><term>Malaisie</term><term>Mâle</term><term>Prédisposition génétique à une maladie</term><term>Sujet âgé</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Malaisie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphatic filariasis (LF) is a parasitic disease caused by threadlike worms of the Brugia and Wuchereria species that live in the human lymphatic system. Regulatory T cells (Tregs) may play a key role in the pathogenesis of LF, and cytotoxic T-lymphocyte antigen-4 (CTLA4) expressed by Tregs is a potential candidate gene because it modulates T-cell activation. A case-control study was performed to establish a potential association of 5 CTLA4 gene promoter single nucleotide polymorphisms (SNPs; rs733618, rs11571316, rs5742909, rs231775, and rs16840252) with the occurrence of LF in an East Malaysian population (320 LF-infected individuals and 150 healthy controls). Polymorphisms were evaluated using TaqMan real-time polymerase chain reaction followed by direct sequencing. LF carriers of the rs733618 AG genotypes (p = 0.02) and those with combined minor allele G carriers (AG + GG; p = 0.01) exhibited a significantly decreased risk for LF. Among the asymptomatic amicrofilaremic cases, positive associations were reported for all genotypes and variants of rs733618 with odds ratios (ORs) ranging from 0.27 to 0.45. In the asymptomatic microfilaremic cases, marker rs231775 exhibited a significant decreased risk, with ORs ranging from 0.50 to 0.57. The study has identified SNPs in the CTLA4 promoter gene that may be functionally linked with susceptibility to LF.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21513760</PMID><DateCreated><Year>2011</Year><Month>06</Month><Day>13</Day></DateCreated><DateCompleted><Year>2011</Year><Month>10</Month><Day>18</Day></DateCompleted><DateRevised><Year>2011</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1166</ISSN><JournalIssue CitedMedium="Internet"><Volume>72</Volume><Issue>7</Issue><PubDate><Year>2011</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Human immunology</Title><ISOAbbreviation>Hum. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Association of CTLA4 gene polymorphisms with lymphatic filariasis in an East Malaysian population.</ArticleTitle><Pagination><MedlinePgn>607-12</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.humimm.2011.03.017</ELocationID><Abstract><AbstractText>Lymphatic filariasis (LF) is a parasitic disease caused by threadlike worms of the Brugia and Wuchereria species that live in the human lymphatic system. Regulatory T cells (Tregs) may play a key role in the pathogenesis of LF, and cytotoxic T-lymphocyte antigen-4 (CTLA4) expressed by Tregs is a potential candidate gene because it modulates T-cell activation. A case-control study was performed to establish a potential association of 5 CTLA4 gene promoter single nucleotide polymorphisms (SNPs; rs733618, rs11571316, rs5742909, rs231775, and rs16840252) with the occurrence of LF in an East Malaysian population (320 LF-infected individuals and 150 healthy controls). Polymorphisms were evaluated using TaqMan real-time polymerase chain reaction followed by direct sequencing. LF carriers of the rs733618 AG genotypes (p = 0.02) and those with combined minor allele G carriers (AG + GG; p = 0.01) exhibited a significantly decreased risk for LF. Among the asymptomatic amicrofilaremic cases, positive associations were reported for all genotypes and variants of rs733618 with odds ratios (ORs) ranging from 0.27 to 0.45. In the asymptomatic microfilaremic cases, marker rs231775 exhibited a significant decreased risk, with ORs ranging from 0.50 to 0.57. The study has identified SNPs in the CTLA4 promoter gene that may be functionally linked with susceptibility to LF.</AbstractText><CopyrightInformation>Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Idris</LastName><ForeName>Zulkarnain Md</ForeName><Initials>ZM</Initials><AffiliationInfo><Affiliation>Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miswan</LastName><ForeName>Noorizan</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Muhi</LastName><ForeName>Jamail</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Mohd</LastName><ForeName>Tajul Ariffin Awang</ForeName><Initials>TA</Initials></Author><Author ValidYN="Y"><LastName>Kun</LastName><ForeName>Jürgen F J</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Noordin</LastName><ForeName>Rahmah</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>04</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Hum Immunol</MedlineTA><NlmUniqueID>8010936</NlmUniqueID><ISSNLinking>0198-8859</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015703">Antigens, CD</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D060908">CTLA-4 Antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C556706">CTLA4 protein, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000483" MajorTopicYN="N">Alleles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015703" MajorTopicYN="N">Antigens, CD</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044466" MajorTopicYN="N">Asian Continental Ancestry Group</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060908" MajorTopicYN="N">CTLA-4 Antigen</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005091" MajorTopicYN="N">Exons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005787" MajorTopicYN="N">Gene Frequency</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="Y">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008296" MajorTopicYN="N" Type="Geographic">Malaysia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011401" MajorTopicYN="N">Promoter Regions, Genetic</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>11</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2011</Year><Month>03</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>03</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>4</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>4</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>10</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21513760</ArticleId><ArticleId IdType="pii">S0198-8859(11)00070-X</ArticleId><ArticleId IdType="doi">10.1016/j.humimm.2011.03.017</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Malaisie</li></country></list><tree><noCountry><name sortKey="Kun, Jurgen F J" sort="Kun, Jurgen F J" uniqKey="Kun J" first="Jürgen F J" last="Kun">Jürgen F J. Kun</name><name sortKey="Miswan, Noorizan" sort="Miswan, Noorizan" uniqKey="Miswan N" first="Noorizan" last="Miswan">Noorizan Miswan</name><name sortKey="Mohd, Tajul Ariffin Awang" sort="Mohd, Tajul Ariffin Awang" uniqKey="Mohd T" first="Tajul Ariffin Awang" last="Mohd">Tajul Ariffin Awang Mohd</name><name sortKey="Muhi, Jamail" sort="Muhi, Jamail" uniqKey="Muhi J" first="Jamail" last="Muhi">Jamail Muhi</name><name sortKey="Noordin, Rahmah" sort="Noordin, Rahmah" uniqKey="Noordin R" first="Rahmah" last="Noordin">Rahmah Noordin</name></noCountry><country name="Malaisie"><noRegion><name sortKey="Idris, Zulkarnain Md" sort="Idris, Zulkarnain Md" uniqKey="Idris Z" first="Zulkarnain Md" last="Idris">Zulkarnain Md Idris</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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