Gene expression in Graves' ophthalmopathy and arm lymphedema: similarities and differences.
Identifieur interne : 004294 ( Ncbi/Merge ); précédent : 004293; suivant : 004295Gene expression in Graves' ophthalmopathy and arm lymphedema: similarities and differences.
Auteurs : Tereza Planck [Suède] ; Hemang Parikh ; H Kan Brorson ; Tuve M Rtensson ; Peter Sman ; Leif Groop ; Bengt Hallengren ; Mikael LantzSource :
- Thyroid : official journal of the American Thyroid Association [ 1557-9077 ] ; 2011.
Descripteurs français
- KwdFr :
- Adipogenèse (physiologie), Adulte, Adulte d'âge moyen, Analyse de profil d'expression de gènes, Analyse sur microréseau, Bras (anatomopathologie), Expression des gènes, Femelle, Humains, Lymphoedème (métabolisme), Lymphoedème (étiologie), Mâle, Ophtalmopathie basedowienne (métabolisme), Protéine apparentée à l'hormone parathyroïdienne (biosynthèse), Régulation négative, Régulation positive, Tissu adipeux (métabolisme), Tumeurs du sein ().
- MESH :
- anatomopathologie : Bras.
- biosynthèse : Protéine apparentée à l'hormone parathyroïdienne.
- métabolisme : Lymphoedème, Ophtalmopathie basedowienne, Tissu adipeux.
- physiologie : Adipogenèse.
- étiologie : Lymphoedème.
- Adulte, Adulte d'âge moyen, Analyse de profil d'expression de gènes, Analyse sur microréseau, Expression des gènes, Femelle, Humains, Mâle, Régulation négative, Régulation positive, Tumeurs du sein.
English descriptors
- KwdEn :
- Adipogenesis (physiology), Adipose Tissue (metabolism), Adult, Arm (pathology), Breast Neoplasms (complications), Down-Regulation, Female, Gene Expression, Gene Expression Profiling, Graves Ophthalmopathy (metabolism), Humans, Lymphedema (etiology), Lymphedema (metabolism), Male, Microarray Analysis, Middle Aged, Parathyroid Hormone-Related Protein (biosynthesis), Up-Regulation.
- MESH :
- chemical , biosynthesis : Parathyroid Hormone-Related Protein.
- complications : Breast Neoplasms.
- etiology : Lymphedema.
- metabolism : Adipose Tissue, Graves Ophthalmopathy, Lymphedema.
- pathology : Arm.
- physiology : Adipogenesis.
- Adult, Down-Regulation, Female, Gene Expression, Gene Expression Profiling, Humans, Male, Microarray Analysis, Middle Aged, Up-Regulation.
Abstract
Graves' ophthalmopathy (GO) and lymphedema share some pathogenetic mechanisms, such as edema, inflammation, and adipogenesis. The aim of this study was to examine similarities and differences between chronic GO and chronic lymphedema.
DOI: 10.1089/thy.2010.0217
PubMed: 21510802
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pubmed:21510802Le document en format XML
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Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Parikh, Hemang" sort="Parikh, Hemang" uniqKey="Parikh H" first="Hemang" last="Parikh">Hemang Parikh</name></author><author><name sortKey="Brorson, H Kan" sort="Brorson, H Kan" uniqKey="Brorson H" first="H Kan" last="Brorson">H Kan Brorson</name></author><author><name sortKey="M Rtensson, Tuve" sort="M Rtensson, Tuve" uniqKey="M Rtensson T" first="Tuve" last="M Rtensson">Tuve M Rtensson</name></author><author><name sortKey=" Sman, Peter" sort=" Sman, Peter" uniqKey=" Sman P" first="Peter" last=" Sman">Peter Sman</name></author><author><name sortKey="Groop, Leif" sort="Groop, Leif" uniqKey="Groop L" first="Leif" last="Groop">Leif Groop</name></author><author><name sortKey="Hallengren, Bengt" sort="Hallengren, Bengt" uniqKey="Hallengren B" first="Bengt" last="Hallengren">Bengt Hallengren</name></author><author><name sortKey="Lantz, Mikael" sort="Lantz, Mikael" uniqKey="Lantz M" first="Mikael" last="Lantz">Mikael Lantz</name></author></analytic><series><title level="j">Thyroid : official journal of the American Thyroid Association</title><idno type="eISSN">1557-9077</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipogenesis (physiology)</term><term>Adipose Tissue (metabolism)</term><term>Adult</term><term>Arm (pathology)</term><term>Breast Neoplasms (complications)</term><term>Down-Regulation</term><term>Female</term><term>Gene Expression</term><term>Gene Expression Profiling</term><term>Graves Ophthalmopathy (metabolism)</term><term>Humans</term><term>Lymphedema (etiology)</term><term>Lymphedema (metabolism)</term><term>Male</term><term>Microarray Analysis</term><term>Middle Aged</term><term>Parathyroid Hormone-Related Protein (biosynthesis)</term><term>Up-Regulation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adipogenèse (physiologie)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de profil d'expression de gènes</term><term>Analyse sur microréseau</term><term>Bras (anatomopathologie)</term><term>Expression des gènes</term><term>Femelle</term><term>Humains</term><term>Lymphoedème (métabolisme)</term><term>Lymphoedème (étiologie)</term><term>Mâle</term><term>Ophtalmopathie basedowienne (métabolisme)</term><term>Protéine apparentée à l'hormone parathyroïdienne (biosynthèse)</term><term>Régulation négative</term><term>Régulation positive</term><term>Tissu adipeux (métabolisme)</term><term>Tumeurs du sein ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Parathyroid Hormone-Related Protein</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Bras</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Protéine apparentée à l'hormone parathyroïdienne</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adipose Tissue</term><term>Graves Ophthalmopathy</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphoedème</term><term>Ophtalmopathie basedowienne</term><term>Tissu adipeux</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Arm</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Adipogenèse</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Adipogenesis</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Down-Regulation</term><term>Female</term><term>Gene Expression</term><term>Gene Expression Profiling</term><term>Humans</term><term>Male</term><term>Microarray Analysis</term><term>Middle Aged</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de profil d'expression de gènes</term><term>Analyse sur microréseau</term><term>Expression des gènes</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Régulation négative</term><term>Régulation positive</term><term>Tumeurs du sein</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Graves' ophthalmopathy (GO) and lymphedema share some pathogenetic mechanisms, such as edema, inflammation, and adipogenesis. The aim of this study was to examine similarities and differences between chronic GO and chronic lymphedema.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21510802</PMID><DateCreated><Year>2011</Year><Month>06</Month><Day>13</Day></DateCreated><DateCompleted><Year>2011</Year><Month>09</Month><Day>26</Day></DateCompleted><DateRevised><Year>2012</Year><Month>10</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1557-9077</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>6</Issue><PubDate><Year>2011</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Thyroid : official journal of the American Thyroid Association</Title><ISOAbbreviation>Thyroid</ISOAbbreviation></Journal><ArticleTitle>Gene expression in Graves' ophthalmopathy and arm lymphedema: similarities and differences.</ArticleTitle><Pagination><MedlinePgn>663-74</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/thy.2010.0217</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Graves' ophthalmopathy (GO) and lymphedema share some pathogenetic mechanisms, such as edema, inflammation, and adipogenesis. The aim of this study was to examine similarities and differences between chronic GO and chronic lymphedema.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Intraorbital adipose tissue was collected from patients with active (n = 10) or chronic GO (n = 10) and thyroid-healthy controls (n = 10). Arm subcutaneous adipose tissue was obtained from patients with chronic arm lymphedema (n = 10), where the unaffected arm served as a control. Gene expression was studied using microarray and real-time polymerase chain reaction.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The following genes were significantly upregulated (p < 0.05) in lymphedema but not in GO and have functions in wound healing, fibrosis, fat metabolism, inflammation, differentiation, development, adhesion, and the cytoskeleton: ATP-binding cassette, sub-family G (WHITE), member 1 (ABCG1), actin, alpha 2, smooth muscle, aorta (ACTA2), secreted frizzled-related protein 2 (SFRP2), tenascin C (TNC), pentraxin-related gene, rapidly induced by IL-1 beta (PTX3), and carboxypeptidase X (M14 family), member 1 (CPMX1). In chronic GO, but not in lymphedema, adipocyte-related immediate early genes known to be overexpressed in patients with active GO were upregulated but at a lower level than previously shown for the active phase. Genes of the Wnt pathway, such as secreted frizzled-related protein 1, 2, and 3, were up- and downregulated in both chronic GO and lymphedema. Parathyroid hormone-like hormone (PTHLH) was downregulated (p = 0.01) and apolipoprotein L domain containing 1 (APOLD1) was upregulated (p = 0.05) in both active and chronic GO.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">There are more differences than similarities between chronic ophthalmopathy and chronic lymphedema, but both conditions exhibit less inflammation and adipogenesis compared to the active phases. In lymphedema, fibrosis dominates. PTHLH, which can inhibit adipogenesis, is downregulated both in active and chronic ophthalmopathy, indicating the possibility of an increased risk of adipogenesis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Planck</LastName><ForeName>Tereza</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Skåne University Hospital, CRC, Malmö, Sweden. tereza.planck@med.lu.se</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parikh</LastName><ForeName>Hemang</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Brorson</LastName><ForeName>Håkan</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Mårtensson</LastName><ForeName>Tuve</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Åsman</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Groop</LastName><ForeName>Leif</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Hallengren</LastName><ForeName>Bengt</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Lantz</LastName><ForeName>Mikael</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>04</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Thyroid</MedlineTA><NlmUniqueID>9104317</NlmUniqueID><ISSNLinking>1050-7256</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C470121">PTHLH protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044162">Parathyroid Hormone-Related Protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Clin Endocrinol (Oxf). 2012 Sep;77(3):486-7</RefSource><PMID Version="1">22288557</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D050156" MajorTopicYN="N">Adipogenesis</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000273" MajorTopicYN="N">Adipose Tissue</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001132" MajorTopicYN="N">Arm</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015536" MajorTopicYN="N">Down-Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015870" MajorTopicYN="N">Gene Expression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020869" MajorTopicYN="Y">Gene Expression Profiling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049970" MajorTopicYN="N">Graves Ophthalmopathy</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046228" MajorTopicYN="N">Microarray Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044162" MajorTopicYN="N">Parathyroid Hormone-Related Protein</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>4</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>4</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>9</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21510802</ArticleId><ArticleId IdType="doi">10.1089/thy.2010.0217</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Suède</li></country></list><tree><noCountry><name sortKey=" Sman, Peter" sort=" Sman, Peter" uniqKey=" Sman P" first="Peter" last=" Sman">Peter Sman</name><name sortKey="Brorson, H Kan" sort="Brorson, H Kan" uniqKey="Brorson H" first="H Kan" last="Brorson">H Kan Brorson</name><name sortKey="Groop, Leif" sort="Groop, Leif" uniqKey="Groop L" first="Leif" last="Groop">Leif Groop</name><name sortKey="Hallengren, Bengt" sort="Hallengren, Bengt" uniqKey="Hallengren B" first="Bengt" last="Hallengren">Bengt Hallengren</name><name sortKey="Lantz, Mikael" sort="Lantz, Mikael" uniqKey="Lantz M" first="Mikael" last="Lantz">Mikael Lantz</name><name sortKey="M Rtensson, Tuve" sort="M Rtensson, Tuve" uniqKey="M Rtensson T" first="Tuve" last="M Rtensson">Tuve M Rtensson</name><name sortKey="Parikh, Hemang" sort="Parikh, Hemang" uniqKey="Parikh H" first="Hemang" last="Parikh">Hemang Parikh</name></noCountry><country name="Suède"><noRegion><name sortKey="Planck, Tereza" sort="Planck, Tereza" uniqKey="Planck T" first="Tereza" last="Planck">Tereza Planck</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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