Utility of Frozen Section Analysis of Sentinel Lymph Node Biopsy for Melanoma in Surgical Decision-Making
Identifieur interne : 003134 ( Ncbi/Merge ); précédent : 003133; suivant : 003135Utility of Frozen Section Analysis of Sentinel Lymph Node Biopsy for Melanoma in Surgical Decision-Making
Auteurs : Weesam Alkhatib [États-Unis] ; Casey Hertzenberg [États-Unis] ; William Jewell [États-Unis] ; Mazin F F. Al-Kasspooles [États-Unis] ; Ivan Damjanov [États-Unis] ; Mark S. Cohen [États-Unis]Source :
- American journal of surgery [ 0002-9610 ] ; 2008.
Abstract
Debate exists whether frozen section analysis of sentinel lymph nodes (SLN) for melanoma is an accurate method to detect metastatic disease to the lymph nodes. The purpose of this study is to evaluate the utility of intra-operative frozen section for SLN’s in melanoma.
We reviewed 133 patients (271 nodes) who underwent a SLN biopsy with frozen section for melanoma between April 2003 and September 2007. Frozen section diagnosis was compared to final diagnosis to determine concordance between intra-operative and postoperative diagnosis.
A total of 11 nodes (8% of patients) were found to have metastatic disease. All patients underwent lymph node dissections at the time of SLN biopsy. No false positive SLN’s were found on frozen section. False negative rate for SLN biopsy frozen section was 1/133 patients (0.8%).
Intra-operative frozen section can be an accurate and reliable tool in the right setting for analysis of sentinel nodes in cutaneous melanoma and deserves further study.
Url:
DOI: 10.1016/j.amjsurg.2008.07.034
PubMed: 19095096
PubMed Central: 2730514
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002757
- to stream Pmc, to step Curation: 002756
- to stream Pmc, to step Checkpoint: 003852
Links to Exploration step
PMC:2730514Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Utility of Frozen Section Analysis of Sentinel Lymph Node Biopsy for Melanoma in Surgical Decision-Making</title>
<author><name sortKey="Alkhatib, Weesam" sort="Alkhatib, Weesam" uniqKey="Alkhatib W" first="Weesam" last="Alkhatib">Weesam Alkhatib</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea> Department of Surgery, University of Kansas Medical Center, Kansas City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hertzenberg, Casey" sort="Hertzenberg, Casey" uniqKey="Hertzenberg C" first="Casey" last="Hertzenberg">Casey Hertzenberg</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea> Department of Surgery, University of Kansas Medical Center, Kansas City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jewell, William" sort="Jewell, William" uniqKey="Jewell W" first="William" last="Jewell">William Jewell</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea> Department of Surgery, University of Kansas Medical Center, Kansas City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Al Kasspooles, Mazin F F" sort="Al Kasspooles, Mazin F F" uniqKey="Al Kasspooles M" first="Mazin F F" last="Al-Kasspooles">Mazin F F. Al-Kasspooles</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea> Department of Surgery, University of Kansas Medical Center, Kansas City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Damjanov, Ivan" sort="Damjanov, Ivan" uniqKey="Damjanov I" first="Ivan" last="Damjanov">Ivan Damjanov</name>
<affiliation wicri:level="2"><nlm:aff id="A2"> Department of Pathology, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea> Department of Pathology, University of Kansas Medical Center, Kansas City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cohen, Mark S" sort="Cohen, Mark S" uniqKey="Cohen M" first="Mark S" last="Cohen">Mark S. Cohen</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea> Department of Surgery, University of Kansas Medical Center, Kansas City</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19095096</idno>
<idno type="pmc">2730514</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730514</idno>
<idno type="RBID">PMC:2730514</idno>
<idno type="doi">10.1016/j.amjsurg.2008.07.034</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">002757</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002757</idno>
<idno type="wicri:Area/Pmc/Curation">002756</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002756</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003852</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003852</idno>
<idno type="wicri:Area/Ncbi/Merge">003134</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Utility of Frozen Section Analysis of Sentinel Lymph Node Biopsy for Melanoma in Surgical Decision-Making</title>
<author><name sortKey="Alkhatib, Weesam" sort="Alkhatib, Weesam" uniqKey="Alkhatib W" first="Weesam" last="Alkhatib">Weesam Alkhatib</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea> Department of Surgery, University of Kansas Medical Center, Kansas City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hertzenberg, Casey" sort="Hertzenberg, Casey" uniqKey="Hertzenberg C" first="Casey" last="Hertzenberg">Casey Hertzenberg</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea> Department of Surgery, University of Kansas Medical Center, Kansas City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jewell, William" sort="Jewell, William" uniqKey="Jewell W" first="William" last="Jewell">William Jewell</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea> Department of Surgery, University of Kansas Medical Center, Kansas City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Al Kasspooles, Mazin F F" sort="Al Kasspooles, Mazin F F" uniqKey="Al Kasspooles M" first="Mazin F F" last="Al-Kasspooles">Mazin F F. Al-Kasspooles</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea> Department of Surgery, University of Kansas Medical Center, Kansas City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Damjanov, Ivan" sort="Damjanov, Ivan" uniqKey="Damjanov I" first="Ivan" last="Damjanov">Ivan Damjanov</name>
<affiliation wicri:level="2"><nlm:aff id="A2"> Department of Pathology, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea> Department of Pathology, University of Kansas Medical Center, Kansas City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cohen, Mark S" sort="Cohen, Mark S" uniqKey="Cohen M" first="Mark S" last="Cohen">Mark S. Cohen</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Kansas</region>
</placeName>
<wicri:cityArea> Department of Surgery, University of Kansas Medical Center, Kansas City</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">American journal of surgery</title>
<idno type="ISSN">0002-9610</idno>
<idno type="eISSN">1879-1883</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P2">Debate exists whether frozen section analysis of sentinel lymph nodes (SLN) for melanoma is an accurate method to detect metastatic disease to the lymph nodes. The purpose of this study is to evaluate the utility of intra-operative frozen section for SLN’s in melanoma.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P3">We reviewed 133 patients (271 nodes) who underwent a SLN biopsy with frozen section for melanoma between April 2003 and September 2007. Frozen section diagnosis was compared to final diagnosis to determine concordance between intra-operative and postoperative diagnosis.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P4">A total of 11 nodes (8% of patients) were found to have metastatic disease. All patients underwent lymph node dissections at the time of SLN biopsy. No false positive SLN’s were found on frozen section. False negative rate for SLN biopsy frozen section was 1/133 patients (0.8%).</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P5">Intra-operative frozen section can be an accurate and reliable tool in the right setting for analysis of sentinel nodes in cutaneous melanoma and deserves further study.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0370473</journal-id>
<journal-id journal-id-type="pubmed-jr-id">471</journal-id>
<journal-id journal-id-type="nlm-ta">Am J Surg</journal-id>
<journal-title>American journal of surgery</journal-title>
<issn pub-type="ppub">0002-9610</issn>
<issn pub-type="epub">1879-1883</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19095096</article-id>
<article-id pub-id-type="pmc">2730514</article-id>
<article-id pub-id-type="doi">10.1016/j.amjsurg.2008.07.034</article-id>
<article-id pub-id-type="manuscript">NIHMS82600</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Utility of Frozen Section Analysis of Sentinel Lymph Node Biopsy for Melanoma in Surgical Decision-Making</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Alkhatib</surname>
<given-names>Weesam</given-names>
</name>
<degrees>MD</degrees>
<xref rid="A1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hertzenberg</surname>
<given-names>Casey</given-names>
</name>
<degrees>MD</degrees>
<xref rid="A1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jewell</surname>
<given-names>William</given-names>
</name>
<degrees>MD</degrees>
<xref rid="A1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Al-Kasspooles</surname>
<given-names>Mazin f F</given-names>
</name>
<degrees>MD</degrees>
<xref rid="A1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Damjanov</surname>
<given-names>Ivan</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref rid="A2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cohen</surname>
<given-names>Mark S</given-names>
</name>
<degrees>MD</degrees>
<xref rid="A1" ref-type="aff">a</xref>
<xref rid="FN1" ref-type="author-notes">c</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
Department of Surgery, University of Kansas Medical Center, Kansas City, KS</aff>
<aff id="A2"><label>b</label>
Department of Pathology, University of Kansas Medical Center, Kansas City, KS</aff>
<author-notes><corresp id="FN1"><label>c</label>
corresponding author: Mark S. Cohen, MD, Assistant Professor of Surgery, Pharmacology, Toxicology & Therapeutics, Section of Surgical Oncology, University of Kansas Medical Center, Room 2035 Sutherland Institute, Mail Stop 2005, 3901 Rainbow Blvd. Kansas City, KS 66160, (913) 588-6568 office, (913) 588-4593 fax, <email>mcohen@kumc.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>30</day>
<month>12</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>12</month>
<year>2009</year>
</pub-date>
<volume>196</volume>
<issue>6</issue>
<fpage>827</fpage>
<lpage>833</lpage>
<abstract><sec id="S1"><title>Background</title>
<p id="P2">Debate exists whether frozen section analysis of sentinel lymph nodes (SLN) for melanoma is an accurate method to detect metastatic disease to the lymph nodes. The purpose of this study is to evaluate the utility of intra-operative frozen section for SLN’s in melanoma.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P3">We reviewed 133 patients (271 nodes) who underwent a SLN biopsy with frozen section for melanoma between April 2003 and September 2007. Frozen section diagnosis was compared to final diagnosis to determine concordance between intra-operative and postoperative diagnosis.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P4">A total of 11 nodes (8% of patients) were found to have metastatic disease. All patients underwent lymph node dissections at the time of SLN biopsy. No false positive SLN’s were found on frozen section. False negative rate for SLN biopsy frozen section was 1/133 patients (0.8%).</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P5">Intra-operative frozen section can be an accurate and reliable tool in the right setting for analysis of sentinel nodes in cutaneous melanoma and deserves further study.</p>
</sec>
</abstract>
<kwd-group><kwd>Sentinel lymph nodes</kwd>
<kwd>melanoma</kwd>
<kwd>frozen section</kwd>
<kwd>completion nodal dissection</kwd>
</kwd-group>
<contract-num rid="RR1">P20 RR015563-08</contract-num>
<contract-sponsor id="RR1">National Center for Research Resources : NCRR</contract-sponsor>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Kansas</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Kansas"><name sortKey="Alkhatib, Weesam" sort="Alkhatib, Weesam" uniqKey="Alkhatib W" first="Weesam" last="Alkhatib">Weesam Alkhatib</name>
</region>
<name sortKey="Al Kasspooles, Mazin F F" sort="Al Kasspooles, Mazin F F" uniqKey="Al Kasspooles M" first="Mazin F F" last="Al-Kasspooles">Mazin F F. Al-Kasspooles</name>
<name sortKey="Cohen, Mark S" sort="Cohen, Mark S" uniqKey="Cohen M" first="Mark S" last="Cohen">Mark S. Cohen</name>
<name sortKey="Damjanov, Ivan" sort="Damjanov, Ivan" uniqKey="Damjanov I" first="Ivan" last="Damjanov">Ivan Damjanov</name>
<name sortKey="Hertzenberg, Casey" sort="Hertzenberg, Casey" uniqKey="Hertzenberg C" first="Casey" last="Hertzenberg">Casey Hertzenberg</name>
<name sortKey="Jewell, William" sort="Jewell, William" uniqKey="Jewell W" first="William" last="Jewell">William Jewell</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003134 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 003134 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:2730514 |texte= Utility of Frozen Section Analysis of Sentinel Lymph Node Biopsy for Melanoma in Surgical Decision-Making }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:19095096" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |