LymphedemaV1, Pmc, Corpus, bibRecord, 002757

Utility of Frozen Section Analysis of Sentinel Lymph Node Biopsy for Melanoma in Surgical Decision-Making

Identifieur interne : 002757 ( Pmc/Corpus ); précédent : 002756; suivant : 002758

Utility of Frozen Section Analysis of Sentinel Lymph Node Biopsy for Melanoma in Surgical Decision-Making

Auteurs : Weesam Alkhatib ; Casey Hertzenberg ; William Jewell ; Mazin F F. Al-Kasspooles ; Ivan Damjanov ; Mark S. Cohen

Source :

American journal of surgery [ 0002-9610 ] ; 2008.

RBID : PMC:2730514

Abstract

Background

Debate exists whether frozen section analysis of sentinel lymph nodes (SLN) for melanoma is an accurate method to detect metastatic disease to the lymph nodes. The purpose of this study is to evaluate the utility of intra-operative frozen section for SLN’s in melanoma.

Methods

We reviewed 133 patients (271 nodes) who underwent a SLN biopsy with frozen section for melanoma between April 2003 and September 2007. Frozen section diagnosis was compared to final diagnosis to determine concordance between intra-operative and postoperative diagnosis.

Results

A total of 11 nodes (8% of patients) were found to have metastatic disease. All patients underwent lymph node dissections at the time of SLN biopsy. No false positive SLN’s were found on frozen section. False negative rate for SLN biopsy frozen section was 1/133 patients (0.8%).

Conclusion

Intra-operative frozen section can be an accurate and reliable tool in the right setting for analysis of sentinel nodes in cutaneous melanoma and deserves further study.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730514

DOI: 10.1016/j.amjsurg.2008.07.034
PubMed: 19095096
PubMed Central: 2730514

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PMC:2730514

Le document en format XML

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<author><name sortKey="Alkhatib, Weesam" sort="Alkhatib, Weesam" uniqKey="Alkhatib W" first="Weesam" last="Alkhatib">Weesam Alkhatib</name>
<affiliation><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
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<author><name sortKey="Hertzenberg, Casey" sort="Hertzenberg, Casey" uniqKey="Hertzenberg C" first="Casey" last="Hertzenberg">Casey Hertzenberg</name>
<affiliation><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
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<author><name sortKey="Jewell, William" sort="Jewell, William" uniqKey="Jewell W" first="William" last="Jewell">William Jewell</name>
<affiliation><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
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<author><name sortKey="Al Kasspooles, Mazin F F" sort="Al Kasspooles, Mazin F F" uniqKey="Al Kasspooles M" first="Mazin F F" last="Al-Kasspooles">Mazin F F. Al-Kasspooles</name>
<affiliation><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
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<author><name sortKey="Damjanov, Ivan" sort="Damjanov, Ivan" uniqKey="Damjanov I" first="Ivan" last="Damjanov">Ivan Damjanov</name>
<affiliation><nlm:aff id="A2"> Department of Pathology, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
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<author><name sortKey="Cohen, Mark S" sort="Cohen, Mark S" uniqKey="Cohen M" first="Mark S" last="Cohen">Mark S. Cohen</name>
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<affiliation><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
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<author><name sortKey="Hertzenberg, Casey" sort="Hertzenberg, Casey" uniqKey="Hertzenberg C" first="Casey" last="Hertzenberg">Casey Hertzenberg</name>
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<author><name sortKey="Jewell, William" sort="Jewell, William" uniqKey="Jewell W" first="William" last="Jewell">William Jewell</name>
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<author><name sortKey="Al Kasspooles, Mazin F F" sort="Al Kasspooles, Mazin F F" uniqKey="Al Kasspooles M" first="Mazin F F" last="Al-Kasspooles">Mazin F F. Al-Kasspooles</name>
<affiliation><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
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<author><name sortKey="Damjanov, Ivan" sort="Damjanov, Ivan" uniqKey="Damjanov I" first="Ivan" last="Damjanov">Ivan Damjanov</name>
<affiliation><nlm:aff id="A2"> Department of Pathology, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
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<author><name sortKey="Cohen, Mark S" sort="Cohen, Mark S" uniqKey="Cohen M" first="Mark S" last="Cohen">Mark S. Cohen</name>
<affiliation><nlm:aff id="A1"> Department of Surgery, University of Kansas Medical Center, Kansas City, KS</nlm:aff>
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<series><title level="j">American journal of surgery</title>
<idno type="ISSN">0002-9610</idno>
<idno type="eISSN">1879-1883</idno>
<imprint><date when="2008">2008</date>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P2">Debate exists whether frozen section analysis of sentinel lymph nodes (SLN) for melanoma is an accurate method to detect metastatic disease to the lymph nodes. The purpose of this study is to evaluate the utility of intra-operative frozen section for SLN’s in melanoma.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P3">We reviewed 133 patients (271 nodes) who underwent a SLN biopsy with frozen section for melanoma between April 2003 and September 2007. Frozen section diagnosis was compared to final diagnosis to determine concordance between intra-operative and postoperative diagnosis.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P4">A total of 11 nodes (8% of patients) were found to have metastatic disease. All patients underwent lymph node dissections at the time of SLN biopsy. No false positive SLN’s were found on frozen section. False negative rate for SLN biopsy frozen section was 1/133 patients (0.8%).</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P5">Intra-operative frozen section can be an accurate and reliable tool in the right setting for analysis of sentinel nodes in cutaneous melanoma and deserves further study.</p>
</sec>
</div>
</front>
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  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">0370473</journal-id>
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<article-id pub-id-type="manuscript">NIHMS82600</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Utility of Frozen Section Analysis of Sentinel Lymph Node Biopsy for Melanoma in Surgical Decision-Making</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Alkhatib</surname>
<given-names>Weesam</given-names>
</name>
<degrees>MD</degrees>
<xref rid="A1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hertzenberg</surname>
<given-names>Casey</given-names>
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<degrees>MD</degrees>
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<contrib contrib-type="author"><name><surname>Jewell</surname>
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<degrees>MD</degrees>
<xref rid="A1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Al-Kasspooles</surname>
<given-names>Mazin f F</given-names>
</name>
<degrees>MD</degrees>
<xref rid="A1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Damjanov</surname>
<given-names>Ivan</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref rid="A2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cohen</surname>
<given-names>Mark S</given-names>
</name>
<degrees>MD</degrees>
<xref rid="A1" ref-type="aff">a</xref>
<xref rid="FN1" ref-type="author-notes">c</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
 Department of Surgery, University of Kansas Medical Center, Kansas City, KS</aff>
<aff id="A2"><label>b</label>
 Department of Pathology, University of Kansas Medical Center, Kansas City, KS</aff>
<author-notes><corresp id="FN1"><label>c</label>
corresponding author: Mark S. Cohen, MD, Assistant Professor of Surgery, Pharmacology, Toxicology & Therapeutics, Section of Surgical Oncology, University of Kansas Medical Center, Room 2035 Sutherland Institute, Mail Stop 2005, 3901 Rainbow Blvd. Kansas City, KS 66160, (913) 588-6568 office, (913) 588-4593 fax, <email>mcohen@kumc.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>30</day>
<month>12</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>12</month>
<year>2009</year>
</pub-date>
<volume>196</volume>
<issue>6</issue>
<fpage>827</fpage>
<lpage>833</lpage>
<abstract><sec id="S1"><title>Background</title>
<p id="P2">Debate exists whether frozen section analysis of sentinel lymph nodes (SLN) for melanoma is an accurate method to detect metastatic disease to the lymph nodes. The purpose of this study is to evaluate the utility of intra-operative frozen section for SLN’s in melanoma.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P3">We reviewed 133 patients (271 nodes) who underwent a SLN biopsy with frozen section for melanoma between April 2003 and September 2007. Frozen section diagnosis was compared to final diagnosis to determine concordance between intra-operative and postoperative diagnosis.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P4">A total of 11 nodes (8% of patients) were found to have metastatic disease. All patients underwent lymph node dissections at the time of SLN biopsy. No false positive SLN’s were found on frozen section. False negative rate for SLN biopsy frozen section was 1/133 patients (0.8%).</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P5">Intra-operative frozen section can be an accurate and reliable tool in the right setting for analysis of sentinel nodes in cutaneous melanoma and deserves further study.</p>
</sec>
</abstract>
<kwd-group><kwd>Sentinel lymph nodes</kwd>
<kwd>melanoma</kwd>
<kwd>frozen section</kwd>
<kwd>completion nodal dissection</kwd>
</kwd-group>
<contract-num rid="RR1">P20 RR015563-08</contract-num>
<contract-sponsor id="RR1">National Center for Research Resources : NCRR</contract-sponsor>
</article-meta>
</front>
</pmc>
</record>

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Utility of Frozen Section Analysis of Sentinel Lymph Node Biopsy for Melanoma in Surgical Decision-Making

Utility of Frozen Section Analysis of Sentinel Lymph Node Biopsy for Melanoma in Surgical Decision-Making

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki