Molecular mechanisms of lymphatic vascular development.
Identifieur interne : 002674 ( Ncbi/Merge ); précédent : 002673; suivant : 002675Molecular mechanisms of lymphatic vascular development.
Auteurs : T. M Kinen [Royaume-Uni] ; C. Norrmén ; T V PetrovaSource :
- Cellular and molecular life sciences : CMLS [ 1420-682X ] ; 2007.
Descripteurs français
- KwdFr :
- Angiopoïétines (physiologie), Animaux, Cellules cultivées, Cellules endothéliales (physiologie), Facteur de croissance endothéliale vasculaire de type A (physiologie), Humains, Lymphangiogenèse (physiologie), Modèles biologiques, Protéines du transport vésiculaire (physiologie), Récepteurs TIE (physiologie), Récepteurs aux facteurs de croissance endothéliale vasculaire (physiologie), Substances de croissance (physiologie), Vaisseaux lymphatiques (cytologie), Vaisseaux lymphatiques (physiologie).
- MESH :
- cytologie : Vaisseaux lymphatiques.
- physiologie : Angiopoïétines, Cellules endothéliales, Facteur de croissance endothéliale vasculaire de type A, Lymphangiogenèse, Protéines du transport vésiculaire, Récepteurs TIE, Récepteurs aux facteurs de croissance endothéliale vasculaire, Substances de croissance, Vaisseaux lymphatiques.
- Animaux, Cellules cultivées, Humains, Modèles biologiques.
English descriptors
- KwdEn :
- Angiopoietins (physiology), Animals, Cells, Cultured, Endothelial Cells (physiology), Growth Substances (physiology), Humans, Lymphangiogenesis (physiology), Lymphatic Vessels (cytology), Lymphatic Vessels (physiology), Models, Biological, Receptors, TIE (physiology), Receptors, Vascular Endothelial Growth Factor (physiology), Vascular Endothelial Growth Factor A (physiology), Vesicular Transport Proteins (physiology).
- MESH :
- chemical , physiology : Angiopoietins, Growth Substances, Receptors, TIE, Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A, Vesicular Transport Proteins.
- cytology : Lymphatic Vessels.
- physiology : Endothelial Cells, Lymphangiogenesis, Lymphatic Vessels.
- Animals, Cells, Cultured, Humans, Models, Biological.
Abstract
Lymphatic vasculature has recently emerged as a prominent area in biomedical research because of its essential role in the maintenance of normal fluid homeostasis and the involvement in pathogenesis of several human diseases, such as solid tumor metastasis, inflammation and lymphedema. Identification of lymphatic endothelial specific markers and regulators, such as VEGFR-3, VEGF-C/D, PROX1, podoplanin, LYVE-1, ephrinB2 and FOXC2, and the development of mouse models have laid a foundation for our understanding of the major steps controlling growth and remodeling of lymphatic vessels. In this review we summarize recent advances in the field and discuss how this knowledge as well as use of model organisms, such as zebrafish and Xenopus, should allow further in depth analysis of the lymphatic vascular system.
DOI: 10.1007/s00018-007-7040-z
PubMed: 17458498
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M Kinen</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX</wicri:regionArea><wicri:noRegion>WC2A 3PX</wicri:noRegion></affiliation></author><author><name sortKey="Norrmen, C" sort="Norrmen, C" uniqKey="Norrmen C" first="C" last="Norrmén">C. 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Identification of lymphatic endothelial specific markers and regulators, such as VEGFR-3, VEGF-C/D, PROX1, podoplanin, LYVE-1, ephrinB2 and FOXC2, and the development of mouse models have laid a foundation for our understanding of the major steps controlling growth and remodeling of lymphatic vessels. In this review we summarize recent advances in the field and discuss how this knowledge as well as use of model organisms, such as zebrafish and Xenopus, should allow further in depth analysis of the lymphatic vascular system.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17458498</PMID><DateCreated><Year>2007</Year><Month>07</Month><Day>20</Day></DateCreated><DateCompleted><Year>2007</Year><Month>09</Month><Day>13</Day></DateCompleted><DateRevised><Year>2009</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1420-682X</ISSN><JournalIssue CitedMedium="Print"><Volume>64</Volume><Issue>15</Issue><PubDate><Year>2007</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Cellular and molecular life sciences : CMLS</Title><ISOAbbreviation>Cell. Mol. Life Sci.</ISOAbbreviation></Journal><ArticleTitle>Molecular mechanisms of lymphatic vascular development.</ArticleTitle><Pagination><MedlinePgn>1915-29</MedlinePgn></Pagination><Abstract><AbstractText>Lymphatic vasculature has recently emerged as a prominent area in biomedical research because of its essential role in the maintenance of normal fluid homeostasis and the involvement in pathogenesis of several human diseases, such as solid tumor metastasis, inflammation and lymphedema. Identification of lymphatic endothelial specific markers and regulators, such as VEGFR-3, VEGF-C/D, PROX1, podoplanin, LYVE-1, ephrinB2 and FOXC2, and the development of mouse models have laid a foundation for our understanding of the major steps controlling growth and remodeling of lymphatic vessels. 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Norrmén</name><name sortKey="Petrova, T V" sort="Petrova, T V" uniqKey="Petrova T" first="T V" last="Petrova">T V Petrova</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="M Kinen, T" sort="M Kinen, T" uniqKey="M Kinen T" first="T" last="M Kinen">T. M Kinen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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