Molecular mechanisms of lymphatic vascular development.
Identifieur interne : 003684 ( PubMed/Corpus ); précédent : 003683; suivant : 003685Molecular mechanisms of lymphatic vascular development.
Auteurs : T. M Kinen ; C. Norrmén ; T V PetrovaSource :
- Cellular and molecular life sciences : CMLS [ 1420-682X ] ; 2007.
English descriptors
- KwdEn :
- Angiopoietins (physiology), Animals, Cells, Cultured, Endothelial Cells (physiology), Growth Substances (physiology), Humans, Lymphangiogenesis (physiology), Lymphatic Vessels (cytology), Lymphatic Vessels (physiology), Models, Biological, Receptors, TIE (physiology), Receptors, Vascular Endothelial Growth Factor (physiology), Vascular Endothelial Growth Factor A (physiology), Vesicular Transport Proteins (physiology).
- MESH :
- chemical , physiology : Angiopoietins, Growth Substances, Receptors, TIE, Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A, Vesicular Transport Proteins.
- cytology : Lymphatic Vessels.
- physiology : Endothelial Cells, Lymphangiogenesis, Lymphatic Vessels.
- Animals, Cells, Cultured, Humans, Models, Biological.
Abstract
Lymphatic vasculature has recently emerged as a prominent area in biomedical research because of its essential role in the maintenance of normal fluid homeostasis and the involvement in pathogenesis of several human diseases, such as solid tumor metastasis, inflammation and lymphedema. Identification of lymphatic endothelial specific markers and regulators, such as VEGFR-3, VEGF-C/D, PROX1, podoplanin, LYVE-1, ephrinB2 and FOXC2, and the development of mouse models have laid a foundation for our understanding of the major steps controlling growth and remodeling of lymphatic vessels. In this review we summarize recent advances in the field and discuss how this knowledge as well as use of model organisms, such as zebrafish and Xenopus, should allow further in depth analysis of the lymphatic vascular system.
DOI: 10.1007/s00018-007-7040-z
PubMed: 17458498
Links to Exploration step
pubmed:17458498Le document en format XML
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<author><name sortKey="M Kinen, T" sort="M Kinen, T" uniqKey="M Kinen T" first="T" last="M Kinen">T. M Kinen</name>
<affiliation><nlm:affiliation>Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK.</nlm:affiliation>
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<author><name sortKey="Norrmen, C" sort="Norrmen, C" uniqKey="Norrmen C" first="C" last="Norrmén">C. Norrmén</name>
</author>
<author><name sortKey="Petrova, T V" sort="Petrova, T V" uniqKey="Petrova T" first="T V" last="Petrova">T V Petrova</name>
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<author><name sortKey="M Kinen, T" sort="M Kinen, T" uniqKey="M Kinen T" first="T" last="M Kinen">T. M Kinen</name>
<affiliation><nlm:affiliation>Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK.</nlm:affiliation>
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<author><name sortKey="Norrmen, C" sort="Norrmen, C" uniqKey="Norrmen C" first="C" last="Norrmén">C. Norrmén</name>
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<author><name sortKey="Petrova, T V" sort="Petrova, T V" uniqKey="Petrova T" first="T V" last="Petrova">T V Petrova</name>
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<series><title level="j">Cellular and molecular life sciences : CMLS</title>
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<imprint><date when="2007" type="published">2007</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Angiopoietins (physiology)</term>
<term>Animals</term>
<term>Cells, Cultured</term>
<term>Endothelial Cells (physiology)</term>
<term>Growth Substances (physiology)</term>
<term>Humans</term>
<term>Lymphangiogenesis (physiology)</term>
<term>Lymphatic Vessels (cytology)</term>
<term>Lymphatic Vessels (physiology)</term>
<term>Models, Biological</term>
<term>Receptors, TIE (physiology)</term>
<term>Receptors, Vascular Endothelial Growth Factor (physiology)</term>
<term>Vascular Endothelial Growth Factor A (physiology)</term>
<term>Vesicular Transport Proteins (physiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Angiopoietins</term>
<term>Growth Substances</term>
<term>Receptors, TIE</term>
<term>Receptors, Vascular Endothelial Growth Factor</term>
<term>Vascular Endothelial Growth Factor A</term>
<term>Vesicular Transport Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Lymphatic Vessels</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Endothelial Cells</term>
<term>Lymphangiogenesis</term>
<term>Lymphatic Vessels</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
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<front><div type="abstract" xml:lang="en">Lymphatic vasculature has recently emerged as a prominent area in biomedical research because of its essential role in the maintenance of normal fluid homeostasis and the involvement in pathogenesis of several human diseases, such as solid tumor metastasis, inflammation and lymphedema. Identification of lymphatic endothelial specific markers and regulators, such as VEGFR-3, VEGF-C/D, PROX1, podoplanin, LYVE-1, ephrinB2 and FOXC2, and the development of mouse models have laid a foundation for our understanding of the major steps controlling growth and remodeling of lymphatic vessels. In this review we summarize recent advances in the field and discuss how this knowledge as well as use of model organisms, such as zebrafish and Xenopus, should allow further in depth analysis of the lymphatic vascular system.</div>
</front>
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<Title>Cellular and molecular life sciences : CMLS</Title>
<ISOAbbreviation>Cell. Mol. Life Sci.</ISOAbbreviation>
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<ArticleTitle>Molecular mechanisms of lymphatic vascular development.</ArticleTitle>
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<Abstract><AbstractText>Lymphatic vasculature has recently emerged as a prominent area in biomedical research because of its essential role in the maintenance of normal fluid homeostasis and the involvement in pathogenesis of several human diseases, such as solid tumor metastasis, inflammation and lymphedema. Identification of lymphatic endothelial specific markers and regulators, such as VEGFR-3, VEGF-C/D, PROX1, podoplanin, LYVE-1, ephrinB2 and FOXC2, and the development of mouse models have laid a foundation for our understanding of the major steps controlling growth and remodeling of lymphatic vessels. In this review we summarize recent advances in the field and discuss how this knowledge as well as use of model organisms, such as zebrafish and Xenopus, should allow further in depth analysis of the lymphatic vascular system.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mäkinen</LastName>
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<AffiliationInfo><Affiliation>Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK.</Affiliation>
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<GrantList CompleteYN="Y"><Grant><GrantID>R01 HL 75183-01</GrantID>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D042682" MajorTopicYN="N">Angiopoietins</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D042583" MajorTopicYN="N">Lymphangiogenesis</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName>
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<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
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<MeshHeading><DescriptorName UI="D042461" MajorTopicYN="N">Vascular Endothelial Growth Factor A</DescriptorName>
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<MeshHeading><DescriptorName UI="D033921" MajorTopicYN="N">Vesicular Transport Proteins</DescriptorName>
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