Topical treatment of acute hindlimb lymphedema of the rat using a troxerutin-phosphatidylcholine complex in liposomal-like microdispersion.
Identifieur interne : 00B600 ( Ncbi/Curation ); précédent : 00B599; suivant : 00B601Topical treatment of acute hindlimb lymphedema of the rat using a troxerutin-phosphatidylcholine complex in liposomal-like microdispersion.
Auteurs : J R Casley-Smith [Australie] ; J R Casley-Smith ; S. Curri ; M. FöldiSource :
- Lymphology [ 0024-7766 ] ; 1993.
Descripteurs français
- KwdFr :
- Administration par voie topique, Animaux, Liposomes, Lymphoedème (traitement médicamenteux), Membre pelvien, O-(bêta-Hydroxyéthyl)rutosides (administration et posologie), O-(bêta-Hydroxyéthyl)rutosides (analogues et dérivés), O-(bêta-Hydroxyéthyl)rutosides (usage thérapeutique), Phosphatidylcholines (administration et posologie), Phosphatidylcholines (usage thérapeutique), Rats, Vecteurs de médicaments.
- MESH :
- administration et posologie : O-(bêta-Hydroxyéthyl)rutosides, Phosphatidylcholines.
- analogues et dérivés : O-(bêta-Hydroxyéthyl)rutosides.
- traitement médicamenteux : Lymphoedème.
- usage thérapeutique : O-(bêta-Hydroxyéthyl)rutosides, Phosphatidylcholines.
- Administration par voie topique, Animaux, Liposomes, Membre pelvien, Rats, Vecteurs de médicaments.
English descriptors
- KwdEn :
- Administration, Topical, Animals, Drug Carriers, Hindlimb, Hydroxyethylrutoside (administration & dosage), Hydroxyethylrutoside (analogs & derivatives), Hydroxyethylrutoside (therapeutic use), Liposomes, Lymphedema (drug therapy), Phosphatidylcholines (administration & dosage), Phosphatidylcholines (therapeutic use), Rats.
- MESH :
- chemical , administration & dosage : Hydroxyethylrutoside, Phosphatidylcholines.
- chemical , analogs & derivatives : Hydroxyethylrutoside.
- chemical , therapeutic use : Hydroxyethylrutoside, Phosphatidylcholines.
- chemical : Drug Carriers, Liposomes.
- drug therapy : Lymphedema.
- Administration, Topical, Animals, Hindlimb, Rats.
Abstract
A new reversible complex between troxerutin and phosphatidylcholine (85-90mg/kg per day), in the form of a liposome-like water microdispersion, was topically applied to the rat thigh in an experimental counterpart of acute lymphedema. After four days there was 75% less hindlimb edema (mean decrease 40% of normal compared to control 10% of normal) in the treated compared with the untreated rats. These findings suggest that this drug preparation may be useful to minimize acute peripheral lymphedema in patients.
PubMed: 8464222
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pubmed:8464222Le document en format XML
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Curri</name></author><author><name sortKey="Foldi, M" sort="Foldi, M" uniqKey="Foldi M" first="M" last="Földi">M. Földi</name></author></analytic><series><title level="j">Lymphology</title><idno type="ISSN">0024-7766</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Topical</term><term>Animals</term><term>Drug Carriers</term><term>Hindlimb</term><term>Hydroxyethylrutoside (administration & dosage)</term><term>Hydroxyethylrutoside (analogs & derivatives)</term><term>Hydroxyethylrutoside (therapeutic use)</term><term>Liposomes</term><term>Lymphedema (drug therapy)</term><term>Phosphatidylcholines (administration & dosage)</term><term>Phosphatidylcholines (therapeutic use)</term><term>Rats</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie topique</term><term>Animaux</term><term>Liposomes</term><term>Lymphoedème (traitement médicamenteux)</term><term>Membre pelvien</term><term>O-(bêta-Hydroxyéthyl)rutosides (administration et posologie)</term><term>O-(bêta-Hydroxyéthyl)rutosides (analogues et dérivés)</term><term>O-(bêta-Hydroxyéthyl)rutosides (usage thérapeutique)</term><term>Phosphatidylcholines (administration et posologie)</term><term>Phosphatidylcholines (usage thérapeutique)</term><term>Rats</term><term>Vecteurs de médicaments</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hydroxyethylrutoside</term><term>Phosphatidylcholines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Hydroxyethylrutoside</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxyethylrutoside</term><term>Phosphatidylcholines</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Drug Carriers</term><term>Liposomes</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>O-(bêta-Hydroxyéthyl)rutosides</term><term>Phosphatidylcholines</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>O-(bêta-Hydroxyéthyl)rutosides</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>O-(bêta-Hydroxyéthyl)rutosides</term><term>Phosphatidylcholines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Topical</term><term>Animals</term><term>Hindlimb</term><term>Rats</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie topique</term><term>Animaux</term><term>Liposomes</term><term>Membre pelvien</term><term>Rats</term><term>Vecteurs de médicaments</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new reversible complex between troxerutin and phosphatidylcholine (85-90mg/kg per day), in the form of a liposome-like water microdispersion, was topically applied to the rat thigh in an experimental counterpart of acute lymphedema. After four days there was 75% less hindlimb edema (mean decrease 40% of normal compared to control 10% of normal) in the treated compared with the untreated rats. These findings suggest that this drug preparation may be useful to minimize acute peripheral lymphedema in patients.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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