Differential proliferative and interleukin-10 responses to fractionated filarial antigens: preferential recognition by patients with chronic lymphatic dysfunction.
Identifieur interne : 00B368 ( Ncbi/Curation ); précédent : 00B367; suivant : 00B369Differential proliferative and interleukin-10 responses to fractionated filarial antigens: preferential recognition by patients with chronic lymphatic dysfunction.
Auteurs : K A Dimock [États-Unis] ; D G Addiss ; M L Eberhard ; P J LammieSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 1994.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Adolescent, Adulte, Adulte d'âge moyen, Animaux, Antigènes d'helminthe (immunologie), Brugia pahangi (immunologie), Chromatographie d'échange d'ions, Chromatographie en phase liquide à haute performance, Enfant, Femelle, Filariose lymphatique (immunologie), Fractionnement chimique, Humains, Immunité cellulaire, Immunotransfert, Interleukine-10 (biosynthèse), Lymphocytes T (immunologie), Maladie chronique, Mâle, Sujet âgé.
- MESH :
- biosynthèse : Interleukine-10.
- immunologie : Antigènes d'helminthe, Brugia pahangi, Filariose lymphatique, Lymphocytes T.
- Activation des lymphocytes, Adolescent, Adulte, Adulte d'âge moyen, Animaux, Chromatographie d'échange d'ions, Chromatographie en phase liquide à haute performance, Enfant, Femelle, Fractionnement chimique, Humains, Immunité cellulaire, Immunotransfert, Maladie chronique, Mâle, Sujet âgé.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Animals, Antigens, Helminth (immunology), Brugia pahangi (immunology), Chemical Fractionation, Child, Chromatography, High Pressure Liquid, Chromatography, Ion Exchange, Chronic Disease, Elephantiasis, Filarial (immunology), Female, Humans, Immunity, Cellular, Immunoblotting, Interleukin-10 (biosynthesis), Lymphocyte Activation, Male, Middle Aged, T-Lymphocytes (immunology).
- MESH :
- chemical , biosynthesis : Interleukin-10.
- chemical , immunology : Antigens, Helminth.
- immunology : Brugia pahangi, Elephantiasis, Filarial, T-Lymphocytes.
- Adolescent, Adult, Aged, Animals, Chemical Fractionation, Child, Chromatography, High Pressure Liquid, Chromatography, Ion Exchange, Chronic Disease, Female, Humans, Immunity, Cellular, Immunoblotting, Lymphocyte Activation, Male, Middle Aged.
Abstract
To characterize filarial antigens that may be associated with the development of chronic lymphatic dysfunction in persons with lymphatic filariasis, T cell responsiveness to Brugia pahangi adult worm extracts and SDS-PAGE antigen fractions were examined among Haitians from an area in which Wuchereria bancrofti is endemic. Greater T cell proliferation and interleukin-10 (IL-10) production were observed in amicrofilaremic patients with hydrocele or elephantiasis than in amicrofilaremic or microfilaremic asymptomatic persons. Antigen fractions that stimulated the highest proliferative responses (in the 25-49 kDa range) and IL-10 production were not identical. Further separation of an immunodominant 30- to 38-kDa fraction by ion exchange high-pressure liquid chromatography identified several subfractions, including a 32-kDa protein band, that elicited T cell responses from patients with elephantiasis or hydrocele. By immunoblot, these patients also had markedly greater humoral reactivity to parasite antigens of approximately 52, 43, 32, and 30 kDa.
PubMed: 8035027
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responses to fractionated filarial antigens: preferential recognition by patients with chronic lymphatic dysfunction.</title><author><name sortKey="Dimock, K A" sort="Dimock, K A" uniqKey="Dimock K" first="K A" last="Dimock">K A Dimock</name><affiliation wicri:level="2"><nlm:affiliation>Division of Parasitic Diseases/F13, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Division of Parasitic Diseases/F13, Centers for Disease Control and Prevention, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Addiss, D G" sort="Addiss, D G" uniqKey="Addiss D" first="D G" last="Addiss">D G Addiss</name></author><author><name sortKey="Eberhard, M L" sort="Eberhard, M L" uniqKey="Eberhard M" first="M L" last="Eberhard">M L Eberhard</name></author><author><name sortKey="Lammie, P J" sort="Lammie, P J" uniqKey="Lammie P" first="P J" last="Lammie">P J Lammie</name></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="ISSN">0022-1899</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Antigens, Helminth (immunology)</term><term>Brugia pahangi (immunology)</term><term>Chemical Fractionation</term><term>Child</term><term>Chromatography, High Pressure Liquid</term><term>Chromatography, Ion Exchange</term><term>Chronic Disease</term><term>Elephantiasis, Filarial (immunology)</term><term>Female</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunoblotting</term><term>Interleukin-10 (biosynthesis)</term><term>Lymphocyte Activation</term><term>Male</term><term>Middle Aged</term><term>T-Lymphocytes (immunology)</term></keywords><keywords 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qualifier="biosynthèse" xml:lang="fr"><term>Interleukine-10</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Brugia pahangi</term><term>Filariose lymphatique</term><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia pahangi</term><term>Elephantiasis, Filarial</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Chemical Fractionation</term><term>Child</term><term>Chromatography, High Pressure Liquid</term><term>Chromatography, Ion Exchange</term><term>Chronic Disease</term><term>Female</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunoblotting</term><term>Lymphocyte Activation</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Chromatographie d'échange d'ions</term><term>Chromatographie en phase liquide à haute performance</term><term>Enfant</term><term>Femelle</term><term>Fractionnement chimique</term><term>Humains</term><term>Immunité cellulaire</term><term>Immunotransfert</term><term>Maladie chronique</term><term>Mâle</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To characterize filarial antigens that may be associated with the development of chronic lymphatic dysfunction in persons with lymphatic filariasis, T cell responsiveness to Brugia pahangi adult worm extracts and SDS-PAGE antigen fractions were examined among Haitians from an area in which Wuchereria bancrofti is endemic. Greater T cell proliferation and interleukin-10 (IL-10) production were observed in amicrofilaremic patients with hydrocele or elephantiasis than in amicrofilaremic or microfilaremic asymptomatic persons. Antigen fractions that stimulated the highest proliferative responses (in the 25-49 kDa range) and IL-10 production were not identical. Further separation of an immunodominant 30- to 38-kDa fraction by ion exchange high-pressure liquid chromatography identified several subfractions, including a 32-kDa protein band, that elicited T cell responses from patients with elephantiasis or hydrocele. By immunoblot, these patients also had markedly greater humoral reactivity to parasite antigens of approximately 52, 43, 32, and 30 kDa.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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