Differential proliferative and interleukin-10 responses to fractionated filarial antigens: preferential recognition by patients with chronic lymphatic dysfunction.
Identifieur interne : 00B368 ( Ncbi/Merge ); précédent : 00B367; suivant : 00B369Differential proliferative and interleukin-10 responses to fractionated filarial antigens: preferential recognition by patients with chronic lymphatic dysfunction.
Auteurs : K A Dimock [États-Unis] ; D G Addiss ; M L Eberhard ; P J LammieSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 1994.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Adolescent, Adulte, Adulte d'âge moyen, Animaux, Antigènes d'helminthe (immunologie), Brugia pahangi (immunologie), Chromatographie d'échange d'ions, Chromatographie en phase liquide à haute performance, Enfant, Femelle, Filariose lymphatique (immunologie), Fractionnement chimique, Humains, Immunité cellulaire, Immunotransfert, Interleukine-10 (biosynthèse), Lymphocytes T (immunologie), Maladie chronique, Mâle, Sujet âgé.
- MESH :
- biosynthèse : Interleukine-10.
- immunologie : Antigènes d'helminthe, Brugia pahangi, Filariose lymphatique, Lymphocytes T.
- Activation des lymphocytes, Adolescent, Adulte, Adulte d'âge moyen, Animaux, Chromatographie d'échange d'ions, Chromatographie en phase liquide à haute performance, Enfant, Femelle, Fractionnement chimique, Humains, Immunité cellulaire, Immunotransfert, Maladie chronique, Mâle, Sujet âgé.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Animals, Antigens, Helminth (immunology), Brugia pahangi (immunology), Chemical Fractionation, Child, Chromatography, High Pressure Liquid, Chromatography, Ion Exchange, Chronic Disease, Elephantiasis, Filarial (immunology), Female, Humans, Immunity, Cellular, Immunoblotting, Interleukin-10 (biosynthesis), Lymphocyte Activation, Male, Middle Aged, T-Lymphocytes (immunology).
- MESH :
- chemical , biosynthesis : Interleukin-10.
- chemical , immunology : Antigens, Helminth.
- immunology : Brugia pahangi, Elephantiasis, Filarial, T-Lymphocytes.
- Adolescent, Adult, Aged, Animals, Chemical Fractionation, Child, Chromatography, High Pressure Liquid, Chromatography, Ion Exchange, Chronic Disease, Female, Humans, Immunity, Cellular, Immunoblotting, Lymphocyte Activation, Male, Middle Aged.
Abstract
To characterize filarial antigens that may be associated with the development of chronic lymphatic dysfunction in persons with lymphatic filariasis, T cell responsiveness to Brugia pahangi adult worm extracts and SDS-PAGE antigen fractions were examined among Haitians from an area in which Wuchereria bancrofti is endemic. Greater T cell proliferation and interleukin-10 (IL-10) production were observed in amicrofilaremic patients with hydrocele or elephantiasis than in amicrofilaremic or microfilaremic asymptomatic persons. Antigen fractions that stimulated the highest proliferative responses (in the 25-49 kDa range) and IL-10 production were not identical. Further separation of an immunodominant 30- to 38-kDa fraction by ion exchange high-pressure liquid chromatography identified several subfractions, including a 32-kDa protein band, that elicited T cell responses from patients with elephantiasis or hydrocele. By immunoblot, these patients also had markedly greater humoral reactivity to parasite antigens of approximately 52, 43, 32, and 30 kDa.
PubMed: 8035027
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preferential recognition by patients with chronic lymphatic dysfunction.</title><author><name sortKey="Dimock, K A" sort="Dimock, K A" uniqKey="Dimock K" first="K A" last="Dimock">K A Dimock</name><affiliation wicri:level="2"><nlm:affiliation>Division of Parasitic Diseases/F13, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Division of Parasitic Diseases/F13, Centers for Disease Control and Prevention, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Addiss, D G" sort="Addiss, D G" uniqKey="Addiss D" first="D G" last="Addiss">D G Addiss</name></author><author><name sortKey="Eberhard, M L" sort="Eberhard, M L" uniqKey="Eberhard M" first="M L" last="Eberhard">M L Eberhard</name></author><author><name sortKey="Lammie, P J" sort="Lammie, P J" uniqKey="Lammie P" first="P J" last="Lammie">P J 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xml:lang="fr"><term>Activation des lymphocytes</term><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia pahangi (immunologie)</term><term>Chromatographie d'échange d'ions</term><term>Chromatographie en phase liquide à haute performance</term><term>Enfant</term><term>Femelle</term><term>Filariose lymphatique (immunologie)</term><term>Fractionnement chimique</term><term>Humains</term><term>Immunité cellulaire</term><term>Immunotransfert</term><term>Interleukine-10 (biosynthèse)</term><term>Lymphocytes T (immunologie)</term><term>Maladie chronique</term><term>Mâle</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interleukin-10</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interleukine-10</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Brugia pahangi</term><term>Filariose lymphatique</term><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia pahangi</term><term>Elephantiasis, Filarial</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Chemical Fractionation</term><term>Child</term><term>Chromatography, High Pressure Liquid</term><term>Chromatography, Ion Exchange</term><term>Chronic Disease</term><term>Female</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunoblotting</term><term>Lymphocyte Activation</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Chromatographie d'échange d'ions</term><term>Chromatographie en phase liquide à haute performance</term><term>Enfant</term><term>Femelle</term><term>Fractionnement chimique</term><term>Humains</term><term>Immunité cellulaire</term><term>Immunotransfert</term><term>Maladie chronique</term><term>Mâle</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To characterize filarial antigens that may be associated with the development of chronic lymphatic dysfunction in persons with lymphatic filariasis, T cell responsiveness to Brugia pahangi adult worm extracts and SDS-PAGE antigen fractions were examined among Haitians from an area in which Wuchereria bancrofti is endemic. Greater T cell proliferation and interleukin-10 (IL-10) production were observed in amicrofilaremic patients with hydrocele or elephantiasis than in amicrofilaremic or microfilaremic asymptomatic persons. Antigen fractions that stimulated the highest proliferative responses (in the 25-49 kDa range) and IL-10 production were not identical. Further separation of an immunodominant 30- to 38-kDa fraction by ion exchange high-pressure liquid chromatography identified several subfractions, including a 32-kDa protein band, that elicited T cell responses from patients with elephantiasis or hydrocele. By immunoblot, these patients also had markedly greater humoral reactivity to parasite antigens of approximately 52, 43, 32, and 30 kDa.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8035027</PMID><DateCreated><Year>1994</Year><Month>08</Month><Day>18</Day></DateCreated><DateCompleted><Year>1994</Year><Month>08</Month><Day>18</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-1899</ISSN><JournalIssue CitedMedium="Print"><Volume>170</Volume><Issue>2</Issue><PubDate><Year>1994</Year><Month>Aug</Month></PubDate></JournalIssue><Title>The Journal of infectious diseases</Title><ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Differential proliferative and interleukin-10 responses to fractionated filarial antigens: preferential recognition by patients with chronic lymphatic dysfunction.</ArticleTitle><Pagination><MedlinePgn>403-12</MedlinePgn></Pagination><Abstract><AbstractText>To characterize filarial antigens that may be associated with the development of chronic lymphatic dysfunction in persons with lymphatic filariasis, T cell responsiveness to Brugia pahangi adult worm extracts and SDS-PAGE antigen fractions were examined among Haitians from an area in which Wuchereria bancrofti is endemic. Greater T cell proliferation and interleukin-10 (IL-10) production were observed in amicrofilaremic patients with hydrocele or elephantiasis than in amicrofilaremic or microfilaremic asymptomatic persons. Antigen fractions that stimulated the highest proliferative responses (in the 25-49 kDa range) and IL-10 production were not identical. Further separation of an immunodominant 30- to 38-kDa fraction by ion exchange high-pressure liquid chromatography identified several subfractions, including a 32-kDa protein band, that elicited T cell responses from patients with elephantiasis or hydrocele. By immunoblot, these patients also had markedly greater humoral reactivity to parasite antigens of approximately 52, 43, 32, and 30 kDa.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dimock</LastName><ForeName>K A</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>Division of Parasitic Diseases/F13, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Addiss</LastName><ForeName>D G</ForeName><Initials>DG</Initials></Author><Author ValidYN="Y"><LastName>Eberhard</LastName><ForeName>M L</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Lammie</LastName><ForeName>P J</ForeName><Initials>PJ</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>AI-02642</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>Y02-00005</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Infect Dis</MedlineTA><NlmUniqueID>0413675</NlmUniqueID><ISSNLinking>0022-1899</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>130068-27-8</RegistryNumber><NameOfSubstance UI="D016753">Interleukin-10</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" 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MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008213" MajorTopicYN="N">Lymphocyte Activation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1994</Year><Month>8</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1994</Year><Month>8</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1994</Year><Month>8</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8035027</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><noCountry><name sortKey="Addiss, D G" sort="Addiss, D G" uniqKey="Addiss D" first="D G" last="Addiss">D G Addiss</name><name sortKey="Eberhard, M L" sort="Eberhard, M L" uniqKey="Eberhard M" first="M L" last="Eberhard">M L Eberhard</name><name sortKey="Lammie, P J" sort="Lammie, P J" uniqKey="Lammie P" first="P J" last="Lammie">P J Lammie</name></noCountry><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Dimock, K A" sort="Dimock, K A" uniqKey="Dimock K" first="K A" last="Dimock">K A Dimock</name></region></country></tree></affiliations></record>Pour manipuler ce document sous 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