Measurement of Circulating Filarial Antigen Levels in Human Blood with a Point-of-Care Test Strip and a Portable Spectrodensitometer.
Identifieur interne : 008214 ( Ncbi/Curation ); précédent : 008213; suivant : 008215Measurement of Circulating Filarial Antigen Levels in Human Blood with a Point-of-Care Test Strip and a Portable Spectrodensitometer.
Auteurs : Cédric B. Chesnais [Oman] ; Johnny Vlaminck ; Billy Kunyu-Shako ; Sébastien D. Pion ; Naomi-Pitchouna Awaca-Uvon ; Gary J. Weil ; Dieudonné Mumba ; Michel BoussinesqSource :
- The American journal of tropical medicine and hygiene [ 1476-1645 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Filariose lymphatique.
- immunologie : Wuchereria bancrofti.
- métabolisme : Wuchereria bancrofti.
- sang : Antigènes d'helminthe.
- Analyse sur le lieu d'intervention, Animaux, Bandelettes réactives, Humains, Sensibilité et spécificité.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antigens, Helminth.
- diagnosis : Elephantiasis, Filarial.
- immunology : Wuchereria bancrofti.
- metabolism : Wuchereria bancrofti.
- Animals, Humans, Point-of-Care Testing, Reagent Strips, Sensitivity and Specificity.
Abstract
The Alere Filariasis Test Strip (FTS) is a qualitative, point-of-care diagnostic tool that detects Wuchereria bancrofti circulating filarial antigen (CFA) in human blood, serum, or plasma. The Global Program to Eliminate Lymphatic Filariasis employs the FTS for mapping filariasis-endemic areas and assessing the success of elimination efforts. The objective of this study was to explore the relationship between the intensity of positive test lines obtained by FTS with CFA levels as determined by enzyme-linked immunosorbent assay (ELISA) with blood and plasma samples from 188 individuals who live in a filariasis-endemic area. The intensity of the FTS test line was assessed visually to provide a semiquantitative score (visual Filariasis Test Strip [vFTS]), and line intensity was measured with a portable spectrodensitometer (quantitative Filariasis Test Strip [qFTS]). These results were compared with antigen levels measured by ELISA in plasma from the same subjects. qFTS measurements were highly correlated with vFTS scores (ρ = 0.94; P < 0.001) and with plasma CFA levels (ρ = 0.91; P < 0.001). Thus, qFTS assessment is a convenient method for quantifying W. bancrofti CFA levels in human blood, which are correlated with adult worm burdens. This tool may be useful for assessing the impact of treatment on adult filarial worms in individuals and communities.
DOI: 10.4269/ajtmh.15-0916
PubMed: 27114288
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Johnny Vlaminck<affiliation><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.</nlm:affiliation>
<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.</nlm:affiliation>
<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.</nlm:affiliation>
<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.</nlm:affiliation>
<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.</nlm:affiliation>
<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.</nlm:affiliation>
<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.</nlm:affiliation>
<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
</affiliation>
Le document en format XML
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<author><name sortKey="Awaca Uvon, Naomi Pitchouna" sort="Awaca Uvon, Naomi Pitchouna" uniqKey="Awaca Uvon N" first="Naomi-Pitchouna" last="Awaca-Uvon">Naomi-Pitchouna Awaca-Uvon</name>
<affiliation><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.</nlm:affiliation>
<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
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<author><name sortKey="Weil, Gary J" sort="Weil, Gary J" uniqKey="Weil G" first="Gary J" last="Weil">Gary J. Weil</name>
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<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
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<author><name sortKey="Mumba, Dieudonne" sort="Mumba, Dieudonne" uniqKey="Mumba D" first="Dieudonné" last="Mumba">Dieudonné Mumba</name>
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<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
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<author><name sortKey="Boussinesq, Michel" sort="Boussinesq, Michel" uniqKey="Boussinesq M" first="Michel" last="Boussinesq">Michel Boussinesq</name>
<affiliation><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.</nlm:affiliation>
<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Measurement of Circulating Filarial Antigen Levels in Human Blood with a Point-of-Care Test Strip and a Portable Spectrodensitometer.</title>
<author><name sortKey="Chesnais, Cedric B" sort="Chesnais, Cedric B" uniqKey="Chesnais C" first="Cédric B" last="Chesnais">Cédric B. Chesnais</name>
<affiliation wicri:level="1"><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo cedric.chesnais@gmail.com.</nlm:affiliation>
<country wicri:rule="url">Oman</country>
<wicri:regionArea>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa</wicri:regionArea>
<wicri:noRegion>Kinshasa</wicri:noRegion>
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<author><name sortKey="Vlaminck, Johnny" sort="Vlaminck, Johnny" uniqKey="Vlaminck J" first="Johnny" last="Vlaminck">Johnny Vlaminck</name>
<affiliation><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.</nlm:affiliation>
<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
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<author><name sortKey="Kunyu Shako, Billy" sort="Kunyu Shako, Billy" uniqKey="Kunyu Shako B" first="Billy" last="Kunyu-Shako">Billy Kunyu-Shako</name>
<affiliation><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.</nlm:affiliation>
<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
</affiliation>
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<author><name sortKey="Pion, Sebastien D" sort="Pion, Sebastien D" uniqKey="Pion S" first="Sébastien D" last="Pion">Sébastien D. Pion</name>
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<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
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<author><name sortKey="Awaca Uvon, Naomi Pitchouna" sort="Awaca Uvon, Naomi Pitchouna" uniqKey="Awaca Uvon N" first="Naomi-Pitchouna" last="Awaca-Uvon">Naomi-Pitchouna Awaca-Uvon</name>
<affiliation><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.</nlm:affiliation>
<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Weil, Gary J" sort="Weil, Gary J" uniqKey="Weil G" first="Gary J" last="Weil">Gary J. Weil</name>
<affiliation><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.</nlm:affiliation>
<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
</affiliation>
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<author><name sortKey="Mumba, Dieudonne" sort="Mumba, Dieudonne" uniqKey="Mumba D" first="Dieudonné" last="Mumba">Dieudonné Mumba</name>
<affiliation><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.</nlm:affiliation>
<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Boussinesq, Michel" sort="Boussinesq, Michel" uniqKey="Boussinesq M" first="Michel" last="Boussinesq">Michel Boussinesq</name>
<affiliation><nlm:affiliation>Unité Mixte Internationale (UMI) 233, Institut de Recherche pour le Développement (IRD), Montpellier, France; Université Montpellier, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1175, Montpellier, France; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Parasitology, National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of the Congo; National Onchocerciasis Control Programme, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.</nlm:affiliation>
<wicri:noCountry code="subField">Democratic Republic of the Congo</wicri:noCountry>
</affiliation>
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<series><title level="j">The American journal of tropical medicine and hygiene</title>
<idno type="eISSN">1476-1645</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antigens, Helminth (blood)</term>
<term>Elephantiasis, Filarial (diagnosis)</term>
<term>Humans</term>
<term>Point-of-Care Testing</term>
<term>Reagent Strips</term>
<term>Sensitivity and Specificity</term>
<term>Wuchereria bancrofti (immunology)</term>
<term>Wuchereria bancrofti (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse sur le lieu d'intervention</term>
<term>Animaux</term>
<term>Antigènes d'helminthe (sang)</term>
<term>Bandelettes réactives</term>
<term>Filariose lymphatique (diagnostic)</term>
<term>Humains</term>
<term>Sensibilité et spécificité</term>
<term>Wuchereria bancrofti (immunologie)</term>
<term>Wuchereria bancrofti (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens, Helminth</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes d'helminthe</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Point-of-Care Testing</term>
<term>Reagent Strips</term>
<term>Sensitivity and Specificity</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse sur le lieu d'intervention</term>
<term>Animaux</term>
<term>Bandelettes réactives</term>
<term>Humains</term>
<term>Sensibilité et spécificité</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The Alere Filariasis Test Strip (FTS) is a qualitative, point-of-care diagnostic tool that detects Wuchereria bancrofti circulating filarial antigen (CFA) in human blood, serum, or plasma. The Global Program to Eliminate Lymphatic Filariasis employs the FTS for mapping filariasis-endemic areas and assessing the success of elimination efforts. The objective of this study was to explore the relationship between the intensity of positive test lines obtained by FTS with CFA levels as determined by enzyme-linked immunosorbent assay (ELISA) with blood and plasma samples from 188 individuals who live in a filariasis-endemic area. The intensity of the FTS test line was assessed visually to provide a semiquantitative score (visual Filariasis Test Strip [vFTS]), and line intensity was measured with a portable spectrodensitometer (quantitative Filariasis Test Strip [qFTS]). These results were compared with antigen levels measured by ELISA in plasma from the same subjects. qFTS measurements were highly correlated with vFTS scores (ρ = 0.94; P < 0.001) and with plasma CFA levels (ρ = 0.91; P < 0.001). Thus, qFTS assessment is a convenient method for quantifying W. bancrofti CFA levels in human blood, which are correlated with adult worm burdens. This tool may be useful for assessing the impact of treatment on adult filarial worms in individuals and communities.</div>
</front>
</TEI>
</record>
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