LymphedemaV1, Ncbi, Curation, bibRecord, 007C99

Early diagnosis of lymph node metastasis: Importance of intranodal pressures

Identifieur interne : 007C99 ( Ncbi/Curation ); précédent : 007C98; suivant : 007D00

Early diagnosis of lymph node metastasis: Importance of intranodal pressures

Auteurs : Yoshinobu Miura ; Mamoru Mikada ; Tomoki Ouchi ; Sachiko Horie ; Kazu Takeda ; Teppei Yamaki ; Maya Sakamoto ; Shiro Mori ; Tetsuya Kodama

Source :

Cancer Science [ 1347-9032 ] ; 2016.

RBID : PMC:4814246

Abstract

Regional lymph node status is an important prognostic indicator of tumor aggressiveness. However, early diagnosis of metastasis using intranodal pressure, at a stage when lymph node size has not changed significantly, has not been investigated. Here, we use an MXH10/Mo‐lpr/lpr mouse model of lymph node metastasis to show that intranodal pressure increases in both the subiliac lymph node and proper axillary lymph node, which are connected by lymphatic vessels, when tumor cells are injected into the subiliac lymph node to induce metastasis to the proper axillary lymph node. We found that intranodal pressure in the subiliac lymph node increased at the stage when metastasis was detected by in vivo bioluminescence, but when proper axillary lymph node volume (measured by high‐frequency ultrasound imaging) had not increased significantly. Intravenously injected liposomes, encapsulating indocyanine green, were detected in solid tumors by in vivo bioluminescence, but not in the proper axillary lymph node. Basic blood vessel and lymphatic channel structures were maintained in the proper axillary lymph node, although sinus histiocytosis was detected. These results show that intranodal pressure in the proper axillary lymph node increases at early stages when metastatic tumor cells have not fully proliferated. Intranodal pressure may be a useful parameter for facilitating early diagnosis of lymph node metastasis.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814246

DOI: 10.1111/cas.12873
PubMed: 26716604
PubMed Central: 4814246

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Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Regional lymph node status is an important prognostic indicator of tumor aggressiveness. However, early diagnosis of metastasis using intranodal pressure, at a stage when lymph node size has not changed significantly, has not been investigated. Here, we use an <styled-content style="fixed-case">MXH</styled-content>
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Early diagnosis of lymph node metastasis: Importance of intranodal pressures

Early diagnosis of lymph node metastasis: Importance of intranodal pressures

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Abstract

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