Early diagnosis of lymph node metastasis: Importance of intranodal pressures
Identifieur interne : 000730 ( Pmc/Curation ); précédent : 000729; suivant : 000731Early diagnosis of lymph node metastasis: Importance of intranodal pressures
Auteurs : Yoshinobu Miura ; Mamoru Mikada ; Tomoki Ouchi ; Sachiko Horie ; Kazu Takeda ; Teppei Yamaki ; Maya Sakamoto ; Shiro Mori ; Tetsuya KodamaSource :
- Cancer Science [ 1347-9032 ] ; 2016.
Abstract
Regional lymph node status is an important prognostic indicator of tumor aggressiveness. However, early diagnosis of metastasis using intranodal pressure, at a stage when lymph node size has not changed significantly, has not been investigated. Here, we use an
Url:
DOI: 10.1111/cas.12873
PubMed: 26716604
PubMed Central: 4814246
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000730
Links to Exploration step
PMC:4814246Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Early diagnosis of lymph node metastasis: Importance of intranodal pressures</title>
<author><name sortKey="Miura, Yoshinobu" sort="Miura, Yoshinobu" uniqKey="Miura Y" first="Yoshinobu" last="Miura">Yoshinobu Miura</name>
<affiliation><nlm:aff id="cas12873-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mikada, Mamoru" sort="Mikada, Mamoru" uniqKey="Mikada M" first="Mamoru" last="Mikada">Mamoru Mikada</name>
<affiliation><nlm:aff id="cas12873-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ouchi, Tomoki" sort="Ouchi, Tomoki" uniqKey="Ouchi T" first="Tomoki" last="Ouchi">Tomoki Ouchi</name>
<affiliation><nlm:aff id="cas12873-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Horie, Sachiko" sort="Horie, Sachiko" uniqKey="Horie S" first="Sachiko" last="Horie">Sachiko Horie</name>
<affiliation><nlm:aff id="cas12873-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Takeda, Kazu" sort="Takeda, Kazu" uniqKey="Takeda K" first="Kazu" last="Takeda">Kazu Takeda</name>
<affiliation><nlm:aff id="cas12873-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yamaki, Teppei" sort="Yamaki, Teppei" uniqKey="Yamaki T" first="Teppei" last="Yamaki">Teppei Yamaki</name>
<affiliation><nlm:aff id="cas12873-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sakamoto, Maya" sort="Sakamoto, Maya" uniqKey="Sakamoto M" first="Maya" last="Sakamoto">Maya Sakamoto</name>
<affiliation><nlm:aff id="cas12873-aff-0003"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mori, Shiro" sort="Mori, Shiro" uniqKey="Mori S" first="Shiro" last="Mori">Shiro Mori</name>
<affiliation><nlm:aff id="cas12873-aff-0001"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="cas12873-aff-0004"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kodama, Tetsuya" sort="Kodama, Tetsuya" uniqKey="Kodama T" first="Tetsuya" last="Kodama">Tetsuya Kodama</name>
<affiliation><nlm:aff id="cas12873-aff-0001"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26716604</idno>
<idno type="pmc">4814246</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814246</idno>
<idno type="RBID">PMC:4814246</idno>
<idno type="doi">10.1111/cas.12873</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000730</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000730</idno>
<idno type="wicri:Area/Pmc/Curation">000730</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000730</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Early diagnosis of lymph node metastasis: Importance of intranodal pressures</title>
<author><name sortKey="Miura, Yoshinobu" sort="Miura, Yoshinobu" uniqKey="Miura Y" first="Yoshinobu" last="Miura">Yoshinobu Miura</name>
<affiliation><nlm:aff id="cas12873-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mikada, Mamoru" sort="Mikada, Mamoru" uniqKey="Mikada M" first="Mamoru" last="Mikada">Mamoru Mikada</name>
<affiliation><nlm:aff id="cas12873-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ouchi, Tomoki" sort="Ouchi, Tomoki" uniqKey="Ouchi T" first="Tomoki" last="Ouchi">Tomoki Ouchi</name>
<affiliation><nlm:aff id="cas12873-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Horie, Sachiko" sort="Horie, Sachiko" uniqKey="Horie S" first="Sachiko" last="Horie">Sachiko Horie</name>
<affiliation><nlm:aff id="cas12873-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Takeda, Kazu" sort="Takeda, Kazu" uniqKey="Takeda K" first="Kazu" last="Takeda">Kazu Takeda</name>
<affiliation><nlm:aff id="cas12873-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yamaki, Teppei" sort="Yamaki, Teppei" uniqKey="Yamaki T" first="Teppei" last="Yamaki">Teppei Yamaki</name>
<affiliation><nlm:aff id="cas12873-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sakamoto, Maya" sort="Sakamoto, Maya" uniqKey="Sakamoto M" first="Maya" last="Sakamoto">Maya Sakamoto</name>
<affiliation><nlm:aff id="cas12873-aff-0003"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mori, Shiro" sort="Mori, Shiro" uniqKey="Mori S" first="Shiro" last="Mori">Shiro Mori</name>
<affiliation><nlm:aff id="cas12873-aff-0001"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="cas12873-aff-0004"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kodama, Tetsuya" sort="Kodama, Tetsuya" uniqKey="Kodama T" first="Tetsuya" last="Kodama">Tetsuya Kodama</name>
<affiliation><nlm:aff id="cas12873-aff-0001"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Cancer Science</title>
<idno type="ISSN">1347-9032</idno>
<idno type="eISSN">1349-7006</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Regional lymph node status is an important prognostic indicator of tumor aggressiveness. However, early diagnosis of metastasis using intranodal pressure, at a stage when lymph node size has not changed significantly, has not been investigated. Here, we use an <styled-content style="fixed-case">MXH</styled-content>
10/Mo‐<italic>lpr</italic>
/<italic>lpr</italic>
mouse model of lymph node metastasis to show that intranodal pressure increases in both the subiliac lymph node and proper axillary lymph node, which are connected by lymphatic vessels, when tumor cells are injected into the subiliac lymph node to induce metastasis to the proper axillary lymph node. We found that intranodal pressure in the subiliac lymph node increased at the stage when metastasis was detected by <italic>in vivo</italic>
bioluminescence, but when proper axillary lymph node volume (measured by high‐frequency ultrasound imaging) had not increased significantly. Intravenously injected liposomes, encapsulating indocyanine green, were detected in solid tumors by <italic>in vivo</italic>
bioluminescence, but not in the proper axillary lymph node. Basic blood vessel and lymphatic channel structures were maintained in the proper axillary lymph node, although sinus histiocytosis was detected. These results show that intranodal pressure in the proper axillary lymph node increases at early stages when metastatic tumor cells have not fully proliferated. Intranodal pressure may be a useful parameter for facilitating early diagnosis of lymph node metastasis.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cancer Sci</journal-id>
<journal-id journal-id-type="iso-abbrev">Cancer Sci</journal-id>
<journal-id journal-id-type="doi">10.1111/(ISSN)1349-7006</journal-id>
<journal-id journal-id-type="publisher-id">CAS</journal-id>
<journal-title-group><journal-title>Cancer Science</journal-title>
</journal-title-group>
<issn pub-type="ppub">1347-9032</issn>
<issn pub-type="epub">1349-7006</issn>
<publisher><publisher-name>John Wiley and Sons Inc.</publisher-name>
<publisher-loc>Hoboken</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26716604</article-id>
<article-id pub-id-type="pmc">4814246</article-id>
<article-id pub-id-type="doi">10.1111/cas.12873</article-id>
<article-id pub-id-type="publisher-id">CAS12873</article-id>
<article-categories><subj-group subj-group-type="overline"><subject>Original Article</subject>
</subj-group>
<subj-group subj-group-type="heading"><subject>Original Articles</subject>
<subj-group subj-group-type="heading"><subject>Basic and Clinical Immunology</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Early diagnosis of lymph node metastasis: Importance of intranodal pressures</article-title>
<alt-title alt-title-type="left-running-head">Miura <italic>et al</italic>
.</alt-title>
</title-group>
<contrib-group><contrib id="cas12873-cr-0001" contrib-type="author"><name><surname>Miura</surname>
<given-names>Yoshinobu</given-names>
</name>
<xref ref-type="aff" rid="cas12873-aff-0001"><sup>1</sup>
</xref>
</contrib>
<contrib id="cas12873-cr-0002" contrib-type="author"><name><surname>Mikada</surname>
<given-names>Mamoru</given-names>
</name>
<xref ref-type="aff" rid="cas12873-aff-0001"><sup>1</sup>
</xref>
</contrib>
<contrib id="cas12873-cr-0003" contrib-type="author"><name><surname>Ouchi</surname>
<given-names>Tomoki</given-names>
</name>
<xref ref-type="aff" rid="cas12873-aff-0001"><sup>1</sup>
</xref>
</contrib>
<contrib id="cas12873-cr-0004" contrib-type="author"><name><surname>Horie</surname>
<given-names>Sachiko</given-names>
</name>
<xref ref-type="aff" rid="cas12873-aff-0002"><sup>2</sup>
</xref>
</contrib>
<contrib id="cas12873-cr-0005" contrib-type="author"><name><surname>Takeda</surname>
<given-names>Kazu</given-names>
</name>
<xref ref-type="aff" rid="cas12873-aff-0001"><sup>1</sup>
</xref>
</contrib>
<contrib id="cas12873-cr-0006" contrib-type="author"><name><surname>Yamaki</surname>
<given-names>Teppei</given-names>
</name>
<xref ref-type="aff" rid="cas12873-aff-0001"><sup>1</sup>
</xref>
</contrib>
<contrib id="cas12873-cr-0007" contrib-type="author"><name><surname>Sakamoto</surname>
<given-names>Maya</given-names>
</name>
<xref ref-type="aff" rid="cas12873-aff-0003"><sup>3</sup>
</xref>
</contrib>
<contrib id="cas12873-cr-0008" contrib-type="author"><name><surname>Mori</surname>
<given-names>Shiro</given-names>
</name>
<xref ref-type="aff" rid="cas12873-aff-0001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="cas12873-aff-0004"><sup>4</sup>
</xref>
</contrib>
<contrib id="cas12873-cr-0009" contrib-type="author" corresp="yes"><name><surname>Kodama</surname>
<given-names>Tetsuya</given-names>
</name>
<xref ref-type="aff" rid="cas12873-aff-0001"><sup>1</sup>
</xref>
</contrib>
</contrib-group>
<aff id="cas12873-aff-0001"><label><sup>1</sup>
</label>
<named-content content-type="organisation-division">Graduate School of Biomedical Engineering</named-content>
<institution>Tohoku University</institution>
<named-content content-type="city">Sendai</named-content>
<country country="JP">Japan</country>
</aff>
<aff id="cas12873-aff-0002"><label><sup>2</sup>
</label>
<named-content content-type="organisation-division">Institute of Development, Aging and Cancer</named-content>
<institution>Tohoku University</institution>
<named-content content-type="city">Sendai</named-content>
<country country="JP">Japan</country>
</aff>
<aff id="cas12873-aff-0003"><label><sup>3</sup>
</label>
<named-content content-type="organisation-division">Department of Oral Diagnosis</named-content>
<institution>Tohoku University Hospital</institution>
<named-content content-type="city">Sendai</named-content>
<country country="JP">Japan</country>
</aff>
<aff id="cas12873-aff-0004"><label><sup>4</sup>
</label>
<named-content content-type="organisation-division">Department of Oral and Maxillofacial Surgery</named-content>
<institution>Tohoku University Hospital</institution>
<named-content content-type="city">Sendai</named-content>
<country country="JP">Japan</country>
</aff>
<author-notes><corresp id="correspondenceTo"><label>*</label>
<bold>Correspondence</bold>
<break></break>
Tetsuya Kodama, Laboratory of Biomedical Engineering for Cancer, Graduate School of Biomedical Engineering, Tohoku University, 4‐1 Seiryo, Aoba Ward, Sendai, Miyagi 980‐8575, Japan.<break></break>
Tel:/Fax: +81‐22‐717‐7583;<break></break>
E‐mail: <email>t.kodama@m.tohoku.ac.jp</email>
<break></break>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>23</day>
<month>2</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="ppub"><month>3</month>
<year>2016</year>
</pub-date>
<volume>107</volume>
<issue>3</issue>
<issue-id pub-id-type="doi">10.1111/cas.2016.107.issue-3</issue-id>
<fpage>224</fpage>
<lpage>232</lpage>
<history><date date-type="received"><day>10</day>
<month>10</month>
<year>2015</year>
</date>
<date date-type="rev-recd"><day>20</day>
<month>12</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>23</day>
<month>12</month>
<year>2015</year>
</date>
</history>
<permissions><pmc-comment> © 2016 Japanese Cancer Association </pmc-comment>
<copyright-statement content-type="article-copyright">© 2015 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.</copyright-statement>
<license license-type="creativeCommonsBy-nc-nd"><license-p>This is an open access article under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/">Creative Commons Attribution‐NonCommercial‐NoDerivs</ext-link>
License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="file:CAS-107-224.pdf"></self-uri>
<abstract id="cas12873-abs-0001"><p>Regional lymph node status is an important prognostic indicator of tumor aggressiveness. However, early diagnosis of metastasis using intranodal pressure, at a stage when lymph node size has not changed significantly, has not been investigated. Here, we use an <styled-content style="fixed-case">MXH</styled-content>
10/Mo‐<italic>lpr</italic>
/<italic>lpr</italic>
mouse model of lymph node metastasis to show that intranodal pressure increases in both the subiliac lymph node and proper axillary lymph node, which are connected by lymphatic vessels, when tumor cells are injected into the subiliac lymph node to induce metastasis to the proper axillary lymph node. We found that intranodal pressure in the subiliac lymph node increased at the stage when metastasis was detected by <italic>in vivo</italic>
bioluminescence, but when proper axillary lymph node volume (measured by high‐frequency ultrasound imaging) had not increased significantly. Intravenously injected liposomes, encapsulating indocyanine green, were detected in solid tumors by <italic>in vivo</italic>
bioluminescence, but not in the proper axillary lymph node. Basic blood vessel and lymphatic channel structures were maintained in the proper axillary lymph node, although sinus histiocytosis was detected. These results show that intranodal pressure in the proper axillary lymph node increases at early stages when metastatic tumor cells have not fully proliferated. Intranodal pressure may be a useful parameter for facilitating early diagnosis of lymph node metastasis.</p>
</abstract>
<kwd-group kwd-group-type="author-generated"><kwd id="cas12873-kwd-0001">Early diagnosis</kwd>
<kwd id="cas12873-kwd-0002">EPR effect</kwd>
<kwd id="cas12873-kwd-0003">intranodal pressure</kwd>
<kwd id="cas12873-kwd-0004">lymph node metastasis</kwd>
<kwd id="cas12873-kwd-0005">lymphatic network</kwd>
<kwd id="cas12873-kwd-0006">mouse model of metastasis</kwd>
</kwd-group>
<funding-group><award-group><funding-source>Kakenhi</funding-source>
<award-id>26293425</award-id>
<award-id>26670856</award-id>
<award-id>25293382</award-id>
<award-id>24659834</award-id>
<award-id>26242051</award-id>
<award-id>24650286</award-id>
</award-group>
</funding-group>
<funding-group><award-group><funding-source>Japan Society for the Promotion of Science</funding-source>
</award-group>
</funding-group>
<counts><page-count count="9"></page-count>
</counts>
<custom-meta-group><custom-meta><meta-name>source-schema-version-number</meta-name>
<meta-value>2.0</meta-value>
</custom-meta>
<custom-meta><meta-name>component-id</meta-name>
<meta-value>cas12873</meta-value>
</custom-meta>
<custom-meta><meta-name>cover-date</meta-name>
<meta-value>March 2016</meta-value>
</custom-meta>
<custom-meta><meta-name>details-of-publishers-convertor</meta-name>
<meta-value>Converter:WILEY_ML3GV2_TO_NLMPMC version:4.8.5 mode:remove_FC converted:30.03.2016</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><p content-type="self-citation"><mixed-citation publication-type="journal" id="cas12873-cit-1001"><source>Cancer Sci</source>
<volume>107</volume>
(<year>2016</year>
) <fpage>224</fpage>
–<lpage>232</lpage>
</mixed-citation>
</p>
</notes>
<notes><fn-group id="cas12873-ntgp-0001"><fn id="cas12873-note-0001"><p><bold>Funding Information</bold>
Japan Society for the Promotion of Science.</p>
</fn>
</fn-group>
</notes>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000730 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000730 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:4814246 |texte= Early diagnosis of lymph node metastasis: Importance of intranodal pressures }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:26716604" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |