The 2015 WHO Classification of Tumors of the Thymus: Continuity and Changes
Identifieur interne : 007779 ( Ncbi/Curation ); précédent : 007778; suivant : 007780The 2015 WHO Classification of Tumors of the Thymus: Continuity and Changes
Auteurs : Alexander Marx [Allemagne] ; John K. C. Chan [République populaire de Chine] ; Jean-Michel Coindre ; Frank Detterbeck ; Nicolas Girard [France] ; Nancy L. Harris [États-Unis] ; Elaine S. Jaffe [États-Unis] ; Michael O. Kurrer [Suisse] ; Edith M. Marom [Israël] ; Andre L. Moreira [États-Unis] ; Kiyoshi Mukai [Japon] ; Attilio Orazi [États-Unis] ; Philipp Ströbel [Allemagne]Source :
- Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [ 1556-0864 ] ; 2015.
Abstract
This overview of the 4th edition of the WHO Classification of thymic tumors has two aims. First, to comprehensively list the established and new tumour entities and variants that are described in the new WHO Classification of thymic epithelial tumors, germ cell tumors, lymphomas, dendritic cell and myeloid neoplasms, and soft tissue tumors of the thymus and mediastinum; second, to highlight major differences in the new WHO Classification that result from the progress that has been made since the 3rd edition in 2004 at immunohistochemical, genetic and conceptual levels. Refined diagnostic criteria for type A, AB, B1–B3 thymomas and thymic squamous cell carcinoma are given and will hopefully improve the reproducibility of the classification and its clinical relevance. The clinical perspective of the classification has been strengthened by involving experts from radiology, thoracic surgery and oncology; by incorporating state-of-the-art PET/CT images; and by depicting prototypic cytological specimens. This makes the thymus section of the new WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart a valuable tool for pathologists, cytologists and clinicians alike. The impact of the new WHO Classification on therapeutic decisions is exemplified in this overview for thymic epithelial tumors and mediastinal lymphomas, and future perspectives and challenges are discussed.
Url:
DOI: 10.1097/JTO.0000000000000654
PubMed: 26295375
PubMed Central: 4581965
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<front><div type="abstract" xml:lang="en"><p id="P1">This overview of the 4<sup>th</sup>
edition of the WHO Classification of thymic tumors has two aims. First, to comprehensively list the established and new tumour entities and variants that are described in the new WHO Classification of thymic epithelial tumors, germ cell tumors, lymphomas, dendritic cell and myeloid neoplasms, and soft tissue tumors of the thymus and mediastinum; second, to highlight major differences in the new WHO Classification that result from the progress that has been made since the 3<sup>rd</sup>
edition in 2004 at immunohistochemical, genetic and conceptual levels. Refined diagnostic criteria for type A, AB, B1–B3 thymomas and thymic squamous cell carcinoma are given and will hopefully improve the reproducibility of the classification and its clinical relevance. The clinical perspective of the classification has been strengthened by involving experts from radiology, thoracic surgery and oncology; by incorporating state-of-the-art PET/CT images; and by depicting prototypic cytological specimens. This makes the thymus section of the new WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart a valuable tool for pathologists, cytologists and clinicians alike. The impact of the new WHO Classification on therapeutic decisions is exemplified in this overview for thymic epithelial tumors and mediastinal lymphomas, and future perspectives and challenges are discussed.</p>
</div>
</front>
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