The 2015 WHO Classification of Tumors of the Thymus: Continuity and Changes
Identifieur interne : 003526 ( Pmc/Corpus ); précédent : 003525; suivant : 003527The 2015 WHO Classification of Tumors of the Thymus: Continuity and Changes
Auteurs : Alexander Marx ; John K. C. Chan ; Jean-Michel Coindre ; Frank Detterbeck ; Nicolas Girard ; Nancy L. Harris ; Elaine S. Jaffe ; Michael O. Kurrer ; Edith M. Marom ; Andre L. Moreira ; Kiyoshi Mukai ; Attilio Orazi ; Philipp StröbelSource :
- Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [ 1556-0864 ] ; 2015.
Abstract
This overview of the 4th edition of the WHO Classification of thymic tumors has two aims. First, to comprehensively list the established and new tumour entities and variants that are described in the new WHO Classification of thymic epithelial tumors, germ cell tumors, lymphomas, dendritic cell and myeloid neoplasms, and soft tissue tumors of the thymus and mediastinum; second, to highlight major differences in the new WHO Classification that result from the progress that has been made since the 3rd edition in 2004 at immunohistochemical, genetic and conceptual levels. Refined diagnostic criteria for type A, AB, B1–B3 thymomas and thymic squamous cell carcinoma are given and will hopefully improve the reproducibility of the classification and its clinical relevance. The clinical perspective of the classification has been strengthened by involving experts from radiology, thoracic surgery and oncology; by incorporating state-of-the-art PET/CT images; and by depicting prototypic cytological specimens. This makes the thymus section of the new WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart a valuable tool for pathologists, cytologists and clinicians alike. The impact of the new WHO Classification on therapeutic decisions is exemplified in this overview for thymic epithelial tumors and mediastinal lymphomas, and future perspectives and challenges are discussed.
Url:
DOI: 10.1097/JTO.0000000000000654
PubMed: 26295375
PubMed Central: 4581965
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Chan</name><affiliation><nlm:aff id="A2">Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China</nlm:aff></affiliation></author><author><name sortKey="Coindre, Jean Michel" sort="Coindre, Jean Michel" uniqKey="Coindre J" first="Jean-Michel" last="Coindre">Jean-Michel Coindre</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Detterbeck, Frank" sort="Detterbeck, Frank" uniqKey="Detterbeck F" first="Frank" last="Detterbeck">Frank Detterbeck</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Girard, Nicolas" sort="Girard, Nicolas" uniqKey="Girard N" first="Nicolas" last="Girard">Nicolas Girard</name><affiliation><nlm:aff id="A5">Department of Respiratory Medicine, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Harris, Nancy L" sort="Harris, Nancy L" uniqKey="Harris N" first="Nancy L." last="Harris">Nancy L. Harris</name><affiliation><nlm:aff id="A6">Department of Pathology, Massachusetts General Hospital, Boston, USA</nlm:aff></affiliation></author><author><name sortKey="Jaffe, Elaine S" sort="Jaffe, Elaine S" uniqKey="Jaffe E" first="Elaine S." last="Jaffe">Elaine S. Jaffe</name><affiliation><nlm:aff id="A7">Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Kurrer, Michael O" sort="Kurrer, Michael O" uniqKey="Kurrer M" first="Michael O." last="Kurrer">Michael O. Kurrer</name><affiliation><nlm:aff id="A8">Gemeinschaftspraxis für Pathologie, Box 1529, Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Marom, Edith M" sort="Marom, Edith M" uniqKey="Marom E" first="Edith M." last="Marom">Edith M. Marom</name><affiliation><nlm:aff id="A9">Department of Diagnostic Imaging, The Chaim Sheba Medical Center, Tel Hashomer, Israel</nlm:aff></affiliation></author><author><name sortKey="Moreira, Andre L" sort="Moreira, Andre L" uniqKey="Moreira A" first="Andre L." last="Moreira">Andre L. Moreira</name><affiliation><nlm:aff id="A10">Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Mukai, Kiyoshi" sort="Mukai, Kiyoshi" uniqKey="Mukai K" first="Kiyoshi" last="Mukai">Kiyoshi Mukai</name><affiliation><nlm:aff id="A11">Department of Diagnostic Pathology, Saiseikai Central Hospital, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Orazi, Attilio" sort="Orazi, Attilio" uniqKey="Orazi A" first="Attilio" last="Orazi">Attilio Orazi</name><affiliation><nlm:aff id="A12">Department of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York Presbyterian Hospital, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Strobel, Philipp" sort="Strobel, Philipp" uniqKey="Strobel P" first="Philipp" last="Ströbel">Philipp Ströbel</name><affiliation><nlm:aff id="A13">Department of Pathology, Institute of Pathology, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26295375</idno><idno type="pmc">4581965</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581965</idno><idno type="RBID">PMC:4581965</idno><idno type="doi">10.1097/JTO.0000000000000654</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">003526</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003526</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The 2015 WHO Classification of Tumors of the Thymus: Continuity and Changes</title><author><name sortKey="Marx, Alexander" sort="Marx, Alexander" uniqKey="Marx A" first="Alexander" last="Marx">Alexander Marx</name><affiliation><nlm:aff id="A1">Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Chan, John K C" sort="Chan, John K C" uniqKey="Chan J" first="John K. C." last="Chan">John K. C. Chan</name><affiliation><nlm:aff id="A2">Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China</nlm:aff></affiliation></author><author><name sortKey="Coindre, Jean Michel" sort="Coindre, Jean Michel" uniqKey="Coindre J" first="Jean-Michel" last="Coindre">Jean-Michel Coindre</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Detterbeck, Frank" sort="Detterbeck, Frank" uniqKey="Detterbeck F" first="Frank" last="Detterbeck">Frank Detterbeck</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Girard, Nicolas" sort="Girard, Nicolas" uniqKey="Girard N" first="Nicolas" last="Girard">Nicolas Girard</name><affiliation><nlm:aff id="A5">Department of Respiratory Medicine, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Harris, Nancy L" sort="Harris, Nancy L" uniqKey="Harris N" first="Nancy L." last="Harris">Nancy L. Harris</name><affiliation><nlm:aff id="A6">Department of Pathology, Massachusetts General Hospital, Boston, USA</nlm:aff></affiliation></author><author><name sortKey="Jaffe, Elaine S" sort="Jaffe, Elaine S" uniqKey="Jaffe E" first="Elaine S." last="Jaffe">Elaine S. Jaffe</name><affiliation><nlm:aff id="A7">Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Kurrer, Michael O" sort="Kurrer, Michael O" uniqKey="Kurrer M" first="Michael O." last="Kurrer">Michael O. Kurrer</name><affiliation><nlm:aff id="A8">Gemeinschaftspraxis für Pathologie, Box 1529, Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Marom, Edith M" sort="Marom, Edith M" uniqKey="Marom E" first="Edith M." last="Marom">Edith M. Marom</name><affiliation><nlm:aff id="A9">Department of Diagnostic Imaging, The Chaim Sheba Medical Center, Tel Hashomer, Israel</nlm:aff></affiliation></author><author><name sortKey="Moreira, Andre L" sort="Moreira, Andre L" uniqKey="Moreira A" first="Andre L." last="Moreira">Andre L. Moreira</name><affiliation><nlm:aff id="A10">Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Mukai, Kiyoshi" sort="Mukai, Kiyoshi" uniqKey="Mukai K" first="Kiyoshi" last="Mukai">Kiyoshi Mukai</name><affiliation><nlm:aff id="A11">Department of Diagnostic Pathology, Saiseikai Central Hospital, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Orazi, Attilio" sort="Orazi, Attilio" uniqKey="Orazi A" first="Attilio" last="Orazi">Attilio Orazi</name><affiliation><nlm:aff id="A12">Department of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York Presbyterian Hospital, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Strobel, Philipp" sort="Strobel, Philipp" uniqKey="Strobel P" first="Philipp" last="Ströbel">Philipp Ströbel</name><affiliation><nlm:aff id="A13">Department of Pathology, Institute of Pathology, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer</title><idno type="ISSN">1556-0864</idno><idno type="eISSN">1556-1380</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">This overview of the 4<sup>th</sup> edition of the WHO Classification of thymic tumors has two aims. First, to comprehensively list the established and new tumour entities and variants that are described in the new WHO Classification of thymic epithelial tumors, germ cell tumors, lymphomas, dendritic cell and myeloid neoplasms, and soft tissue tumors of the thymus and mediastinum; second, to highlight major differences in the new WHO Classification that result from the progress that has been made since the 3<sup>rd</sup> edition in 2004 at immunohistochemical, genetic and conceptual levels. Refined diagnostic criteria for type A, AB, B1–B3 thymomas and thymic squamous cell carcinoma are given and will hopefully improve the reproducibility of the classification and its clinical relevance. The clinical perspective of the classification has been strengthened by involving experts from radiology, thoracic surgery and oncology; by incorporating state-of-the-art PET/CT images; and by depicting prototypic cytological specimens. This makes the thymus section of the new WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart a valuable tool for pathologists, cytologists and clinicians alike. The impact of the new WHO Classification on therapeutic decisions is exemplified in this overview for thymic epithelial tumors and mediastinal lymphomas, and future perspectives and challenges are discussed.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101274235</journal-id><journal-id journal-id-type="pubmed-jr-id">33311</journal-id><journal-id journal-id-type="nlm-ta">J Thorac Oncol</journal-id><journal-id journal-id-type="iso-abbrev">J Thorac Oncol</journal-id><journal-title-group><journal-title>Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer</journal-title></journal-title-group><issn pub-type="ppub">1556-0864</issn><issn pub-type="epub">1556-1380</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26295375</article-id><article-id pub-id-type="pmc">4581965</article-id><article-id pub-id-type="doi">10.1097/JTO.0000000000000654</article-id><article-id pub-id-type="manuscript">NIHMS708656</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The 2015 WHO Classification of Tumors of the Thymus: Continuity and Changes</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Marx</surname><given-names>Alexander</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>John K.C.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A2">**</xref></contrib><contrib contrib-type="author"><name><surname>Coindre</surname><given-names>Jean-Michel</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">***;</xref></contrib><contrib contrib-type="author"><name><surname>Detterbeck</surname><given-names>Frank</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A4">****;</xref></contrib><contrib contrib-type="author"><name><surname>Girard</surname><given-names>Nicolas</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A5">†</xref></contrib><contrib contrib-type="author"><name><surname>Harris</surname><given-names>Nancy L.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">‡</xref></contrib><contrib contrib-type="author"><name><surname>Jaffe</surname><given-names>Elaine S.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A7">§</xref></contrib><contrib contrib-type="author"><name><surname>Kurrer</surname><given-names>Michael O.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A8">#</xref></contrib><contrib contrib-type="author"><name><surname>Marom</surname><given-names>Edith M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A9">††</xref></contrib><contrib contrib-type="author"><name><surname>Moreira</surname><given-names>Andre L.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A10">‡‡</xref></contrib><contrib contrib-type="author"><name><surname>Mukai</surname><given-names>Kiyoshi</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A11">§§</xref></contrib><contrib contrib-type="author"><name><surname>Orazi</surname><given-names>Attilio</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A12">||||</xref></contrib><contrib contrib-type="author"><name><surname>Ströbel</surname><given-names>Philipp</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A13">¶¶</xref></contrib></contrib-group><aff id="A1"><label>*</label>Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany</aff><aff id="A2"><label>**</label>Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China</aff><aff id="A3"><label>***</label>Department of Pathology, Institut Bergonié, Bordeaux, France</aff><aff id="A4"><label>****</label>Department of Thoracic Surgery, Yale University School of Medicine, New Haven, Connecticut, USA</aff><aff id="A5"><label>†</label>Department of Respiratory Medicine, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon, France</aff><aff id="A6"><label>‡</label>Department of Pathology, Massachusetts General Hospital, Boston, USA</aff><aff id="A7"><label>§</label>Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MA, USA</aff><aff id="A8"><label>#</label>Gemeinschaftspraxis für Pathologie, Box 1529, Zurich, Switzerland</aff><aff id="A9"><label>††</label>Department of Diagnostic Imaging, The Chaim Sheba Medical Center, Tel Hashomer, Israel</aff><aff id="A10"><label>‡‡</label>Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</aff><aff id="A11"><label>§§</label>Department of Diagnostic Pathology, Saiseikai Central Hospital, Tokyo, Japan</aff><aff id="A12"><label>||||</label>Department of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York Presbyterian Hospital, New York, NY, USA</aff><aff id="A13"><label>¶¶</label>Department of Pathology, Institute of Pathology, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany</aff><author-notes><corresp id="FN1">Address for correspondence: Alexander Marx, MD, Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1–3, D-68167 Mannheim, Germany. <email>alexander.marx@umm.de</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>1</day><month>8</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2016</year></pub-date><volume>10</volume><issue>10</issue><fpage>1383</fpage><lpage>1395</lpage><pmc-comment>elocation-id from pubmed: 10.1097/JTO.0000000000000654</pmc-comment>
<abstract><p id="P1">This overview of the 4<sup>th</sup> edition of the WHO Classification of thymic tumors has two aims. First, to comprehensively list the established and new tumour entities and variants that are described in the new WHO Classification of thymic epithelial tumors, germ cell tumors, lymphomas, dendritic cell and myeloid neoplasms, and soft tissue tumors of the thymus and mediastinum; second, to highlight major differences in the new WHO Classification that result from the progress that has been made since the 3<sup>rd</sup> edition in 2004 at immunohistochemical, genetic and conceptual levels. Refined diagnostic criteria for type A, AB, B1–B3 thymomas and thymic squamous cell carcinoma are given and will hopefully improve the reproducibility of the classification and its clinical relevance. The clinical perspective of the classification has been strengthened by involving experts from radiology, thoracic surgery and oncology; by incorporating state-of-the-art PET/CT images; and by depicting prototypic cytological specimens. This makes the thymus section of the new WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart a valuable tool for pathologists, cytologists and clinicians alike. The impact of the new WHO Classification on therapeutic decisions is exemplified in this overview for thymic epithelial tumors and mediastinal lymphomas, and future perspectives and challenges are discussed.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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