Lymphangiogenic factors, mechanisms, and applications
Identifieur interne : 006378 ( Ncbi/Curation ); précédent : 006377; suivant : 006379Lymphangiogenic factors, mechanisms, and applications
Auteurs : Wei Zheng ; Aleksanteri Aspelund ; Kari Alitalo [Finlande]Source :
- The Journal of Clinical Investigation [ 0021-9738 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Antinéoplasiques.
- physiologie : Protéines angiogéniques.
- physiopathologie : Tumeurs, Vaisseaux lymphatiques.
- traitement médicamenteux : Tumeurs.
- Animaux, Humains, Lymphangiogenèse, Thérapie moléculaire ciblée, Transduction du signal.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antineoplastic Agents.
- chemical , physiology : Angiogenic Proteins.
- drug effects : Lymphangiogenesis.
- drug therapy : Neoplasms.
- physiopathology : Lymphatic Vessels, Neoplasms.
- Animals, Humans, Molecular Targeted Therapy, Signal Transduction.
Abstract
Lymphangiogenesis, the growth of lymphatic vessels, is essential in embryonic development. In adults, it is involved in many pathological processes such as lymphedema, inflammatory diseases, and tumor metastasis. Advances during the past decade have dramatically increased the knowledge of the mechanisms of lymphangiogenesis, including the roles of transcription factors, lymphangiogenic growth factors and their receptors, and intercellular and intracellular signaling cascades. Strategies based on these mechanisms are being tested in the treatment of various human diseases such as cancer, lymphedema, and tissue allograft rejection. This Review summarizes the recent progress on lymphangiogenic mechanisms and their applications in disease treatment.
Url:
DOI: 10.1172/JCI71603
PubMed: 24590272
PubMed Central: 3934166
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PMC:3934166Le document en format XML
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<term>Lymphangiogenesis (drug effects)</term>
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<term>Neoplasms (physiopathology)</term>
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<term>Protéines angiogéniques (physiologie)</term>
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<term>Transduction du signal</term>
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<term>Tumeurs (traitement médicamenteux)</term>
<term>Vaisseaux lymphatiques (physiopathologie)</term>
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<front><div type="abstract" xml:lang="en"><p>Lymphangiogenesis, the growth of lymphatic vessels, is essential in embryonic development. In adults, it is involved in many pathological processes such as lymphedema, inflammatory diseases, and tumor metastasis. Advances during the past decade have dramatically increased the knowledge of the mechanisms of lymphangiogenesis, including the roles of transcription factors, lymphangiogenic growth factors and their receptors, and intercellular and intracellular signaling cascades. Strategies based on these mechanisms are being tested in the treatment of various human diseases such as cancer, lymphedema, and tissue allograft rejection. This Review summarizes the recent progress on lymphangiogenic mechanisms and their applications in disease treatment.</p>
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