Lymphangiogenic factors, mechanisms, and applications
Identifieur interne : 004843 ( Pmc/Corpus ); précédent : 004842; suivant : 004844Lymphangiogenic factors, mechanisms, and applications
Auteurs : Wei Zheng ; Aleksanteri Aspelund ; Kari AlitaloSource :
- The Journal of Clinical Investigation [ 0021-9738 ] ; 2014.
Abstract
Lymphangiogenesis, the growth of lymphatic vessels, is essential in embryonic development. In adults, it is involved in many pathological processes such as lymphedema, inflammatory diseases, and tumor metastasis. Advances during the past decade have dramatically increased the knowledge of the mechanisms of lymphangiogenesis, including the roles of transcription factors, lymphangiogenic growth factors and their receptors, and intercellular and intracellular signaling cascades. Strategies based on these mechanisms are being tested in the treatment of various human diseases such as cancer, lymphedema, and tissue allograft rejection. This Review summarizes the recent progress on lymphangiogenic mechanisms and their applications in disease treatment.
Url:
DOI: 10.1172/JCI71603
PubMed: 24590272
PubMed Central: 3934166
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PMC:3934166Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphangiogenic factors, mechanisms, and applications</title><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name></author><author><name sortKey="Aspelund, Aleksanteri" sort="Aspelund, Aleksanteri" uniqKey="Aspelund A" first="Aleksanteri" last="Aspelund">Aleksanteri Aspelund</name></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24590272</idno><idno type="pmc">3934166</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934166</idno><idno type="RBID">PMC:3934166</idno><idno type="doi">10.1172/JCI71603</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">004843</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004843</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lymphangiogenic factors, mechanisms, and applications</title><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name></author><author><name sortKey="Aspelund, Aleksanteri" sort="Aspelund, Aleksanteri" uniqKey="Aspelund A" first="Aleksanteri" last="Aspelund">Aleksanteri Aspelund</name></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></author></analytic><series><title level="j">The Journal of Clinical Investigation</title><idno type="ISSN">0021-9738</idno><idno type="eISSN">1558-8238</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lymphangiogenesis, the growth of lymphatic vessels, is essential in embryonic development. In adults, it is involved in many pathological processes such as lymphedema, inflammatory diseases, and tumor metastasis. Advances during the past decade have dramatically increased the knowledge of the mechanisms of lymphangiogenesis, including the roles of transcription factors, lymphangiogenic growth factors and their receptors, and intercellular and intracellular signaling cascades. Strategies based on these mechanisms are being tested in the treatment of various human diseases such as cancer, lymphedema, and tissue allograft rejection. This Review summarizes the recent progress on lymphangiogenic mechanisms and their applications in disease treatment.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Invest</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Invest</journal-id><journal-id journal-id-type="publisher-id">J CLIN INVEST</journal-id><journal-title-group><journal-title>The Journal of Clinical Investigation</journal-title></journal-title-group><issn pub-type="ppub">0021-9738</issn><issn pub-type="epub">1558-8238</issn><publisher><publisher-name>American Society for Clinical Investigation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24590272</article-id><article-id pub-id-type="pmc">3934166</article-id><article-id pub-id-type="publisher-id">71603</article-id><article-id pub-id-type="doi">10.1172/JCI71603</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Series</subject></subj-group></article-categories><title-group><article-title>Lymphangiogenic factors, mechanisms, and applications</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Wei</given-names></name></contrib><contrib contrib-type="author"><name><surname>Aspelund</surname><given-names>Aleksanteri</given-names></name></contrib><contrib contrib-type="author"><name><surname>Alitalo</surname><given-names>Kari</given-names></name></contrib></contrib-group><aff id="JCI71603">Wihuri Research Institute and Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland.</aff><author-notes><corresp>Address correspondence to: Kari Alitalo, Wihuri Research Institute and Translational Cancer Biology Program, P.O.B. 63 (Haartmaninkatu 8), FIN-00014, University of Helsinki, Finland. Phone: 358.9.1912.5511; Fax: 358.9.1912.5510; E-mail:
<email>kari.alitalo@helsinki.fi</email>.
</corresp></author-notes><pub-date pub-type="epub"><day>3</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>3</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>1</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 9 months and
29 days and was based on the
<volume>124</volume><issue>3</issue><fpage>878</fpage><lpage>887</lpage><permissions><copyright-statement>Copyright © 2014, American Society for Clinical Investigation</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p>Lymphangiogenesis, the growth of lymphatic vessels, is essential in embryonic development. In adults, it is involved in many pathological processes such as lymphedema, inflammatory diseases, and tumor metastasis. Advances during the past decade have dramatically increased the knowledge of the mechanisms of lymphangiogenesis, including the roles of transcription factors, lymphangiogenic growth factors and their receptors, and intercellular and intracellular signaling cascades. Strategies based on these mechanisms are being tested in the treatment of various human diseases such as cancer, lymphedema, and tissue allograft rejection. This Review summarizes the recent progress on lymphangiogenic mechanisms and their applications in disease treatment.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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