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Risk of Decline in Upper-Body Function and Symptoms Among Older Breast Cancer Patients

Identifieur interne : 002227 ( Ncbi/Curation ); précédent : 002226; suivant : 002228

Risk of Decline in Upper-Body Function and Symptoms Among Older Breast Cancer Patients

Auteurs : Jennifer L. Westrup [États-Unis] ; Timothy L. Lash [États-Unis] ; Soe Soe Thwin [États-Unis] ; Rebecca A. Silliman [États-Unis]

Source :

Journal of General Internal Medicine [ 0884-8734 ] ; 2006.

RBID : PMC:1484738

Abstract

BACKGROUND

Decline in upper-body function and development of upper-body symptoms are adverse effects of breast cancer therapy and may affect functional independence, particularly among older survivors. The long-term risks and predictors are poorly understood.

OBJECTIVE

To characterize the risk of decline in upper-body function and development of symptoms over 4 years of follow-up.

DESIGN

We used a prospective cohort design.

PARTICIPANTS

Six hundred and forty-four early stage breast cancer patients 65 years old or older at surgery enrolled in Rhode Island, North Carolina, Minnesota, and Los Angeles between 1996 and 1999.

MEASUREMENTS

Upper-body function and symptoms were self-reported at baseline, 6, 15 months, and annually thereafter to 51 months after surgery.

RESULTS

One half of the participants had a decline in upper-body function and one-quarter developed upper-body symptoms. Breast cancer patients were 5-fold more likely to have a decline in upper-body function over 4 years of follow-up than a similar cohort without breast cancer. Better baseline mental health protected against a decline in upper-body function (odds ratio [OR]=0.93, 95% confidence interval [CI] 0.88 to 0.97 for 8-point higher mental health index). Baseline obesity (OR for body mass index [BMI] ≥30 kg/m² vs <30 kg/m²=2.5, CI=1.6 to 4.0) and axillary node dissection (OR for axillary dissection vs not=3.9, CI=1.1 to 14) predicted the development of upper-body symptoms.

CONCLUSIONS

Primary care physicians should address upper-body function and symptoms with older breast cancer patients, and inform them that these complications of breast cancer treatment are common.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1484738

DOI: 10.1111/j.1525-1497.2006.00384.x
PubMed: 16686807
PubMed Central: 1484738

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PMC:1484738

Le document en format XML

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<front><div type="abstract" xml:lang="en"><sec><title>BACKGROUND</title>
<p>Decline in upper-body function and development of upper-body symptoms are adverse effects of breast cancer therapy and may affect functional independence, particularly among older survivors. The long-term risks and predictors are poorly understood.</p>
</sec>
<sec><title>OBJECTIVE</title>
<p>To characterize the risk of decline in upper-body function and development of symptoms over 4 years of follow-up.</p>
</sec>
<sec><title>DESIGN</title>
<p>We used a prospective cohort design.</p>
</sec>
<sec><title>PARTICIPANTS</title>
<p>Six hundred and forty-four early stage breast cancer patients 65 years old or older at surgery enrolled in Rhode Island, North Carolina, Minnesota, and Los Angeles between 1996 and 1999.</p>
</sec>
<sec><title>MEASUREMENTS</title>
<p>Upper-body function and symptoms were self-reported at baseline, 6, 15 months, and annually thereafter to 51 months after surgery.</p>
</sec>
<sec><title>RESULTS</title>
<p>One half of the participants had a decline in upper-body function and one-quarter developed upper-body symptoms. Breast cancer patients were 5-fold more likely to have a decline in upper-body function over 4 years of follow-up than a similar cohort without breast cancer. Better baseline mental health protected against a decline in upper-body function (odds ratio [OR]=0.93, 95% confidence interval [CI] 0.88 to 0.97 for 8-point higher mental health index). Baseline obesity (OR for body mass index [BMI] ≥30 kg/m<sup>2</sup>
 vs <30 kg/m<sup>2</sup>
=2.5, CI=1.6 to 4.0) and axillary node dissection (OR for axillary dissection vs not=3.9, CI=1.1 to 14) predicted the development of upper-body symptoms.</p>
</sec>
<sec><title>CONCLUSIONS</title>
<p>Primary care physicians should address upper-body function and symptoms with older breast cancer patients, and inform them that these complications of breast cancer treatment are common.</p>
</sec>
</div>
</front>
</TEI>
</record>

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Risk of Decline in Upper-Body Function and Symptoms Among Older Breast Cancer Patients

Risk of Decline in Upper-Body Function and Symptoms Among Older Breast Cancer Patients

Source :

Abstract

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Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki