Renal abnormalities in microfilaremic patients with Bancroftian filariasis.
Identifieur interne : 001F91 ( Ncbi/Curation ); précédent : 001F90; suivant : 001F92Renal abnormalities in microfilaremic patients with Bancroftian filariasis.
Auteurs : G. Dreyer [Brésil] ; E A Ottesen ; E. Galdino ; L. Andrade ; A. Rocha ; Z. Medeiros ; I. Moura ; I. Casimiro ; F. Beliz ; A. CoutinhoSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 1992.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Azote uréique sanguin, Créatinine (sang), Créatinine (urine), Diéthylcarbamazine (usage thérapeutique), Femelle, Filariose lymphatique (physiopathologie), Filariose lymphatique (sang), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (urine), Humains, Hématurie (étiologie), Microfilaria, Mâle, Personnel militaire, Poumon éosinophile (physiopathologie), Poumon éosinophile (sang), Poumon éosinophile (traitement médicamenteux), Poumon éosinophile (urine), Protéinurie (étiologie), Rein (physiopathologie), Wuchereria bancrofti, Études de suivi, Études prospectives.
- MESH :
- physiopathologie : Filariose lymphatique, Poumon éosinophile, Rein.
- sang : Créatinine, Filariose lymphatique, Poumon éosinophile.
- traitement médicamenteux : Filariose lymphatique, Poumon éosinophile.
- usage thérapeutique : Créatinine, Diéthylcarbamazine, Filariose lymphatique, Poumon éosinophile.
- étiologie : Hématurie, Protéinurie.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Azote uréique sanguin, Femelle, Humains, Microfilaria, Mâle, Personnel militaire, Wuchereria bancrofti, Études de suivi, Études prospectives.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Blood Urea Nitrogen, Creatinine (blood), Creatinine (urine), Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (blood), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (physiopathology), Elephantiasis, Filarial (urine), Female, Follow-Up Studies, Hematuria (etiology), Humans, Kidney (physiopathology), Male, Microfilariae, Middle Aged, Military Personnel, Prospective Studies, Proteinuria (etiology), Pulmonary Eosinophilia (blood), Pulmonary Eosinophilia (drug therapy), Pulmonary Eosinophilia (physiopathology), Pulmonary Eosinophilia (urine), Wuchereria bancrofti.
- MESH :
- chemical , blood : Creatinine.
- chemical , therapeutic use : Diethylcarbamazine.
- chemical , urine : Creatinine.
- blood : Elephantiasis, Filarial, Pulmonary Eosinophilia.
- drug therapy : Elephantiasis, Filarial, Pulmonary Eosinophilia.
- etiology : Hematuria, Proteinuria.
- physiopathology : Elephantiasis, Filarial, Kidney, Pulmonary Eosinophilia.
- urine : Elephantiasis, Filarial, Pulmonary Eosinophilia.
- Adolescent, Adult, Animals, Blood Urea Nitrogen, Female, Follow-Up Studies, Humans, Male, Microfilariae, Middle Aged, Military Personnel, Prospective Studies, Wuchereria bancrofti.
Abstract
To determine the frequency of renal abnormalities occurring with Bancroftian filarial infections and to assess the effects of treatment on such abnormalities, we initiated a prospective, hospital-based study of 20 microfilaremic and five amicrofilaremic patients with Wuchereria bancrofti infections. Thorough clinical evaluations and detailed renal assessments were made prior to treatment and at multiple time points for 60 days following a standard twelve-day course of treatment with diethylcarbamazine (DEC). There were two important findings. First, even prior to DEC treatment, almost half of the microfilaremic patients had hematuria and/or proteinuria. Second, treatment with DEC induced these same abnormalities in almost all of the remaining microfilaremic patients. However, this DEC-induced hematuria and/or proteinuria was transient, and the long-term response to DEC in all of the microfilaremic patients was resolution of the abnormal renal findings during the two-month followup period. In the amicrofilaremic study patients, no hematuria or proteinuria was detected before, during, or after treatment with DEC.
PubMed: 1621900
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Dreyer</name><affiliation wicri:level="1"><nlm:affiliation>Centro de Pesquisas Aggeu Magalhaes, Fiocruz, Recife, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro de Pesquisas Aggeu Magalhaes, Fiocruz, Recife</wicri:regionArea><wicri:noRegion>Recife</wicri:noRegion></affiliation></author><author><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name></author><author><name sortKey="Galdino, E" sort="Galdino, E" uniqKey="Galdino E" first="E" last="Galdino">E. Galdino</name></author><author><name sortKey="Andrade, L" sort="Andrade, L" uniqKey="Andrade L" first="L" last="Andrade">L. Andrade</name></author><author><name sortKey="Rocha, A" sort="Rocha, A" uniqKey="Rocha A" first="A" last="Rocha">A. Rocha</name></author><author><name sortKey="Medeiros, Z" sort="Medeiros, Z" uniqKey="Medeiros Z" first="Z" last="Medeiros">Z. Medeiros</name></author><author><name sortKey="Moura, I" sort="Moura, I" uniqKey="Moura I" first="I" last="Moura">I. Moura</name></author><author><name sortKey="Casimiro, I" sort="Casimiro, I" uniqKey="Casimiro I" first="I" last="Casimiro">I. Casimiro</name></author><author><name sortKey="Beliz, F" sort="Beliz, F" uniqKey="Beliz F" first="F" last="Beliz">F. Beliz</name></author><author><name sortKey="Coutinho, A" sort="Coutinho, A" uniqKey="Coutinho A" first="A" last="Coutinho">A. Coutinho</name></author></analytic><series><title level="j">The American journal of tropical medicine and hygiene</title><idno type="ISSN">0002-9637</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Blood Urea Nitrogen</term><term>Creatinine (blood)</term><term>Creatinine (urine)</term><term>Diethylcarbamazine (therapeutic use)</term><term>Elephantiasis, Filarial (blood)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (physiopathology)</term><term>Elephantiasis, Filarial (urine)</term><term>Female</term><term>Follow-Up Studies</term><term>Hematuria (etiology)</term><term>Humans</term><term>Kidney (physiopathology)</term><term>Male</term><term>Microfilariae</term><term>Middle Aged</term><term>Military Personnel</term><term>Prospective Studies</term><term>Proteinuria (etiology)</term><term>Pulmonary Eosinophilia (blood)</term><term>Pulmonary Eosinophilia (drug therapy)</term><term>Pulmonary Eosinophilia (physiopathology)</term><term>Pulmonary Eosinophilia (urine)</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Azote uréique sanguin</term><term>Créatinine (sang)</term><term>Créatinine (urine)</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Femelle</term><term>Filariose lymphatique (physiopathologie)</term><term>Filariose lymphatique (sang)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filariose lymphatique (urine)</term><term>Humains</term><term>Hématurie (étiologie)</term><term>Microfilaria</term><term>Mâle</term><term>Personnel militaire</term><term>Poumon éosinophile (physiopathologie)</term><term>Poumon éosinophile (sang)</term><term>Poumon éosinophile (traitement médicamenteux)</term><term>Poumon éosinophile (urine)</term><term>Protéinurie (étiologie)</term><term>Rein (physiopathologie)</term><term>Wuchereria bancrofti</term><term>Études de suivi</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Creatinine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Creatinine</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Pulmonary Eosinophilia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Pulmonary Eosinophilia</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hematuria</term><term>Proteinuria</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Poumon éosinophile</term><term>Rein</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Kidney</term><term>Pulmonary Eosinophilia</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Créatinine</term><term>Filariose lymphatique</term><term>Poumon éosinophile</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term><term>Poumon éosinophile</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Pulmonary Eosinophilia</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Créatinine</term><term>Diéthylcarbamazine</term><term>Filariose lymphatique</term><term>Poumon éosinophile</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hématurie</term><term>Protéinurie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Blood Urea Nitrogen</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Microfilariae</term><term>Middle Aged</term><term>Military Personnel</term><term>Prospective Studies</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Azote uréique sanguin</term><term>Femelle</term><term>Humains</term><term>Microfilaria</term><term>Mâle</term><term>Personnel militaire</term><term>Wuchereria bancrofti</term><term>Études de suivi</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine the frequency of renal abnormalities occurring with Bancroftian filarial infections and to assess the effects of treatment on such abnormalities, we initiated a prospective, hospital-based study of 20 microfilaremic and five amicrofilaremic patients with Wuchereria bancrofti infections. Thorough clinical evaluations and detailed renal assessments were made prior to treatment and at multiple time points for 60 days following a standard twelve-day course of treatment with diethylcarbamazine (DEC). There were two important findings. First, even prior to DEC treatment, almost half of the microfilaremic patients had hematuria and/or proteinuria. Second, treatment with DEC induced these same abnormalities in almost all of the remaining microfilaremic patients. However, this DEC-induced hematuria and/or proteinuria was transient, and the long-term response to DEC in all of the microfilaremic patients was resolution of the abnormal renal findings during the two-month followup period. In the amicrofilaremic study patients, no hematuria or proteinuria was detected before, during, or after treatment with DEC.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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