[A case of yellow nail syndrome associated with eosinophilic bronchial disease successfully treated with clarithromycin and budesonide].
Identifieur interne : 001F90 ( Ncbi/Curation ); précédent : 001F89; suivant : 001F91[A case of yellow nail syndrome associated with eosinophilic bronchial disease successfully treated with clarithromycin and budesonide].
Auteurs : Mikio Toyoshima ; Kingo Chinda ; Takafumi SudaSource :
- Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society [ 1343-3490 ] ; 2005.
Descripteurs français
- KwdFr :
- Anti-inflammatoires (administration et posologie), Antibactériens (administration et posologie), Association de médicaments, Budésonide (administration et posologie), Clarithromycine (administration et posologie), Dilatation des bronches (traitement médicamenteux), Humains, Lymphoedème (traitement médicamenteux), Maladies des bronches (), Maladies des bronches (traitement médicamenteux), Mâle, Onychopathies (), Sinusite (traitement médicamenteux), Sujet âgé, Syndrome, Éosinophilie (), Éosinophilie (traitement médicamenteux).
- MESH :
- administration et posologie : Anti-inflammatoires, Antibactériens, Budésonide, Clarithromycine.
- traitement médicamenteux : Dilatation des bronches, Lymphoedème, Maladies des bronches, Sinusite, Éosinophilie.
- Association de médicaments, Humains, Maladies des bronches, Mâle, Onychopathies, Sujet âgé, Syndrome, Éosinophilie.
English descriptors
- KwdEn :
- Aged, Anti-Bacterial Agents (administration & dosage), Anti-Inflammatory Agents (administration & dosage), Bronchial Diseases (complications), Bronchial Diseases (drug therapy), Bronchiectasis (drug therapy), Budesonide (administration & dosage), Clarithromycin (administration & dosage), Drug Therapy, Combination, Eosinophilia (complications), Eosinophilia (drug therapy), Humans, Lymphedema (drug therapy), Male, Nail Diseases (complications), Sinusitis (drug therapy), Syndrome.
- MESH :
- chemical , administration & dosage : Anti-Bacterial Agents, Anti-Inflammatory Agents, Budesonide, Clarithromycin.
- complications : Bronchial Diseases, Eosinophilia, Nail Diseases.
- drug therapy : Bronchial Diseases, Bronchiectasis, Eosinophilia, Lymphedema, Sinusitis.
- Aged, Drug Therapy, Combination, Humans, Male, Syndrome.
Abstract
A 78-year-old man was referred to our hospital complaining of chronic productive cough. Physical examination revealed yellowish, thin nails and pretibial edema. A chest computed tomograph showed bilateral bronchiectasis. A sinus radiograph showed the findings of chronic sinusitis. From these findings, yellow nail syndrome was diagnosed. Long-term low-dose macrolide therapy with 400 mg/day clarithromycin was started and his symptoms began to gradually improve. However, complete resolution of his symptoms was not achieved and fiberoptic bronchoscopy was performed. Transbronchial biopsy specimen obtained from the right second carina showed bronchial asthma-like findings such as eosinophilic infiltration, thickening of the basement membrane, mucosal edema and goblet cell hyperplasia. Airflow reversibility was not detected. Thus a diagnosis of coexistence of yellow nail syndrome and eosinohilic bronchial disease was established. Further improvement of his symptoms was achieved by additional therapy with 800 microg/day budesonide and 100 microg/day salmeterol. To the best of our knowledge, this is the first report of a case of yellow nail syndrome associated with eosinophilic bronchial disease successfully treated with long-term low-dose macrolides and inhaled corticosteroids.
PubMed: 16218418
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Mikio Toyoshima<affiliation><nlm:affiliation>Department of Respiratory Medicine, Hamamatsu Rousai Hospital.</nlm:affiliation><wicri:noCountry code="subField">Hamamatsu Rousai Hospital</wicri:noCountry></affiliation>Le document en format XML
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type="pmid">16218418</idno><idno type="wicri:Area/PubMed/Corpus">003B80</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003B80</idno><idno type="wicri:Area/PubMed/Curation">003B80</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003B80</idno><idno type="wicri:Area/PubMed/Checkpoint">003B80</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003B80</idno><idno type="wicri:Area/Ncbi/Merge">001F90</idno><idno type="wicri:Area/Ncbi/Curation">001F90</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[A case of yellow nail syndrome associated with eosinophilic bronchial disease successfully treated with clarithromycin and budesonide].</title><author><name sortKey="Toyoshima, Mikio" sort="Toyoshima, Mikio" uniqKey="Toyoshima M" first="Mikio" last="Toyoshima">Mikio Toyoshima</name><affiliation><nlm:affiliation>Department of Respiratory Medicine, Hamamatsu Rousai Hospital.</nlm:affiliation><wicri:noCountry code="subField">Hamamatsu Rousai Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Chinda, Kingo" sort="Chinda, Kingo" uniqKey="Chinda K" first="Kingo" last="Chinda">Kingo Chinda</name></author><author><name sortKey="Suda, Takafumi" sort="Suda, Takafumi" uniqKey="Suda T" first="Takafumi" last="Suda">Takafumi Suda</name></author></analytic><series><title level="j">Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society</title><idno type="ISSN">1343-3490</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Anti-Bacterial Agents (administration & dosage)</term><term>Anti-Inflammatory Agents (administration & dosage)</term><term>Bronchial Diseases (complications)</term><term>Bronchial Diseases (drug therapy)</term><term>Bronchiectasis (drug therapy)</term><term>Budesonide (administration & dosage)</term><term>Clarithromycin (administration & dosage)</term><term>Drug Therapy, Combination</term><term>Eosinophilia (complications)</term><term>Eosinophilia (drug therapy)</term><term>Humans</term><term>Lymphedema (drug therapy)</term><term>Male</term><term>Nail Diseases (complications)</term><term>Sinusitis (drug therapy)</term><term>Syndrome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anti-inflammatoires (administration et posologie)</term><term>Antibactériens (administration et posologie)</term><term>Association de médicaments</term><term>Budésonide (administration et posologie)</term><term>Clarithromycine (administration et posologie)</term><term>Dilatation des bronches (traitement médicamenteux)</term><term>Humains</term><term>Lymphoedème (traitement médicamenteux)</term><term>Maladies des bronches ()</term><term>Maladies des bronches (traitement médicamenteux)</term><term>Mâle</term><term>Onychopathies ()</term><term>Sinusite (traitement médicamenteux)</term><term>Sujet âgé</term><term>Syndrome</term><term>Éosinophilie ()</term><term>Éosinophilie (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Anti-Inflammatory Agents</term><term>Budesonide</term><term>Clarithromycin</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anti-inflammatoires</term><term>Antibactériens</term><term>Budésonide</term><term>Clarithromycine</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Bronchial Diseases</term><term>Eosinophilia</term><term>Nail Diseases</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Bronchial Diseases</term><term>Bronchiectasis</term><term>Eosinophilia</term><term>Lymphedema</term><term>Sinusitis</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Dilatation des bronches</term><term>Lymphoedème</term><term>Maladies des bronches</term><term>Sinusite</term><term>Éosinophilie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Drug Therapy, Combination</term><term>Humans</term><term>Male</term><term>Syndrome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Association de médicaments</term><term>Humains</term><term>Maladies des bronches</term><term>Mâle</term><term>Onychopathies</term><term>Sujet âgé</term><term>Syndrome</term><term>Éosinophilie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A 78-year-old man was referred to our hospital complaining of chronic productive cough. Physical examination revealed yellowish, thin nails and pretibial edema. A chest computed tomograph showed bilateral bronchiectasis. A sinus radiograph showed the findings of chronic sinusitis. From these findings, yellow nail syndrome was diagnosed. Long-term low-dose macrolide therapy with 400 mg/day clarithromycin was started and his symptoms began to gradually improve. However, complete resolution of his symptoms was not achieved and fiberoptic bronchoscopy was performed. Transbronchial biopsy specimen obtained from the right second carina showed bronchial asthma-like findings such as eosinophilic infiltration, thickening of the basement membrane, mucosal edema and goblet cell hyperplasia. Airflow reversibility was not detected. Thus a diagnosis of coexistence of yellow nail syndrome and eosinohilic bronchial disease was established. Further improvement of his symptoms was achieved by additional therapy with 800 microg/day budesonide and 100 microg/day salmeterol. To the best of our knowledge, this is the first report of a case of yellow nail syndrome associated with eosinophilic bronchial disease successfully treated with long-term low-dose macrolides and inhaled corticosteroids.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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