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Current Concepts of the Pathogenesis and Pathology of Inflammatory Lesions of the Intestine

Identifieur interne : 001502 ( Ncbi/Curation ); précédent : 001501; suivant : 001503

Current Concepts of the Pathogenesis and Pathology of Inflammatory Lesions of the Intestine

Auteurs : Theodor K. Shnitka

Source :

Canadian Medical Association Journal [ 0008-4409 ] ; 1964.

RBID : PMC:1927327

Descripteurs français

KwdFr :
- Adolescent, Anatomopathologie, Biopsie, Cellules épithéliales, Classification, Colite, Diagnostic différentiel, Entérite, Humains, Maladie de Crohn, Microscopie, Microscopie électronique, Rectocolite hémorragique, Rectum, Électrons.
MESH :
- Adolescent, Anatomopathologie, Biopsie, Cellules épithéliales, Classification, Colite, Diagnostic différentiel, Entérite, Humains, Maladie de Crohn, Microscopie, Microscopie électronique, Rectocolite hémorragique, Rectum, Électrons.

English descriptors

KwdEn :
- Adolescent, Biopsy, Classification, Colitis, Colitis, Ulcerative, Crohn Disease, Diagnosis, Differential, Electrons, Enteritis, Epithelial Cells, Humans, Microscopy, Microscopy, Electron, Pathology, Rectum.
MESH :
- Adolescent, Biopsy, Classification, Colitis, Colitis, Ulcerative, Crohn Disease, Diagnosis, Differential, Electrons, Enteritis, Epithelial Cells, Humans, Microscopy, Microscopy, Electron, Pathology, Rectum.

Abstract

The histopathologic lesions of regional enteritis and ulcerative colitis, particularly in their early stages, are distinct and distinguishable, irrespective of the sites that are involved. Regional enteritis is characterized by lymphangiectasis, lymphedema, lymphoid hyperplasia, and granulomatous inflammation of the submucosal and subserosal layers of intestine, whereas chronic ulcerative colitis is an exudative, ulcerative disorder of the mucosal layer that commences with “crypt abscesses” and only in its later stages progresses to deeper coats of the wall.

Electron microscopy of a rectal biopsy from a juvenile patient with chronic ulcerative colitis for five years disclosed a labyrinthine system of clefts and compartments between columnar, mucosal epithelial cells. Regenerated colonic epithelial cells were of primitive, germinal type and featured a “vesicular” rather than a “goblet” pattern of mucus secretion. Clusters of small “clavate fimbriae” projected from the tips of microvilli. Each of these newly recognized substructures measured 30 to 60 mμ. in diameter, and was enclosed by a tri-laminar “unit membrane”, derived from the surface plasma membrane of the cell.

ImagesFig. 1Fig. 2Fig. 3Fig. 4Fig. 5Fig. 6Fig. 7Fig. 8Fig. 9Fig. 10Fig. 11Fig. 12Fig. 13Fig. 14Fig. 15Fig. 16Fig. 17Fig. 18Fig. 19

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1927327

PubMed: 14182565
PubMed Central: 1927327

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PMC:1927327

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>The histopathologic lesions of regional enteritis and ulcerative colitis, particularly in their early stages, are distinct and distinguishable, irrespective of the sites that are involved. Regional enteritis is characterized by lymphangiectasis, lymphedema, lymphoid hyperplasia, and granulomatous inflammation of the submucosal and subserosal layers of intestine, whereas chronic ulcerative colitis is an exudative, ulcerative disorder of the mucosal layer that commences with “crypt abscesses” and only in its later stages progresses to deeper coats of the wall.</p>
<p>Electron microscopy of a rectal biopsy from a juvenile patient with chronic ulcerative colitis for five years disclosed a labyrinthine system of clefts and compartments between columnar, mucosal epithelial cells. Regenerated colonic epithelial cells were of primitive, germinal type and featured a “vesicular” rather than a “goblet” pattern of mucus secretion. Clusters of small “clavate fimbriae” projected from the tips of microvilli. Each of these newly recognized substructures measured 30 to 60 mμ. in diameter, and was enclosed by a tri-laminar “unit membrane”, derived from the surface plasma membrane of the cell.</p>
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Current Concepts of the Pathogenesis and Pathology of Inflammatory Lesions of the Intestine

Current Concepts of the Pathogenesis and Pathology of Inflammatory Lesions of the Intestine

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki