Current Concepts of the Pathogenesis and Pathology of Inflammatory Lesions of the Intestine
Identifieur interne : 001163 ( Pmc/Curation ); précédent : 001162; suivant : 001164Current Concepts of the Pathogenesis and Pathology of Inflammatory Lesions of the Intestine
Auteurs : Theodor K. ShnitkaSource :
- Canadian Medical Association Journal [ 0008-4409 ] ; 1964.
Abstract
The histopathologic lesions of regional enteritis and ulcerative colitis, particularly in their early stages, are distinct and distinguishable, irrespective of the sites that are involved. Regional enteritis is characterized by lymphangiectasis, lymphedema, lymphoid hyperplasia, and granulomatous inflammation of the submucosal and subserosal layers of intestine, whereas chronic ulcerative colitis is an exudative, ulcerative disorder of the mucosal layer that commences with “crypt abscesses” and only in its later stages progresses to deeper coats of the wall.
Electron microscopy of a rectal biopsy from a juvenile patient with chronic ulcerative colitis for five years disclosed a labyrinthine system of clefts and compartments between columnar, mucosal epithelial cells. Regenerated colonic epithelial cells were of primitive, germinal type and featured a “vesicular” rather than a “goblet” pattern of mucus secretion. Clusters of small “clavate fimbriae” projected from the tips of microvilli. Each of these newly recognized substructures measured 30 to 60 mμ. in diameter, and was enclosed by a tri-laminar “unit membrane”, derived from the surface plasma membrane of the cell.
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PubMed: 14182565
PubMed Central: 1927327
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Shnitka</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">14182565</idno><idno type="pmc">1927327</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1927327</idno><idno type="RBID">PMC:1927327</idno><date when="1964">1964</date><idno type="wicri:Area/Pmc/Corpus">001164</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001164</idno><idno type="wicri:Area/Pmc/Curation">001163</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001163</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Current Concepts of the Pathogenesis and Pathology of Inflammatory Lesions of the Intestine</title><author><name sortKey="Shnitka, Theodor K" sort="Shnitka, Theodor K" uniqKey="Shnitka T" first="Theodor K." last="Shnitka">Theodor K. Shnitka</name></author></analytic><series><title level="j">Canadian Medical Association Journal</title><idno type="ISSN">0008-4409</idno><imprint><date when="1964">1964</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The histopathologic lesions of regional enteritis and ulcerative colitis, particularly in their early stages, are distinct and distinguishable, irrespective of the sites that are involved. Regional enteritis is characterized by lymphangiectasis, lymphedema, lymphoid hyperplasia, and granulomatous inflammation of the submucosal and subserosal layers of intestine, whereas chronic ulcerative colitis is an exudative, ulcerative disorder of the mucosal layer that commences with “crypt abscesses” and only in its later stages progresses to deeper coats of the wall.</p><p>Electron microscopy of a rectal biopsy from a juvenile patient with chronic ulcerative colitis for five years disclosed a labyrinthine system of clefts and compartments between columnar, mucosal epithelial cells. Regenerated colonic epithelial cells were of primitive, germinal type and featured a “vesicular” rather than a “goblet” pattern of mucus secretion. Clusters of small “clavate fimbriae” projected from the tips of microvilli. Each of these newly recognized substructures measured 30 to 60 mμ. in diameter, and was enclosed by a tri-laminar “unit membrane”, derived from the surface plasma membrane of the cell.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Fig. 1</label><graphic xlink:href="canmedaj01055-0010-a" xlink:role="8"></graphic></fig><fig id="F2"><label>Fig. 2</label><graphic xlink:href="canmedaj01055-0011-a" xlink:role="9"></graphic></fig><fig id="F3"><label>Fig. 3</label><graphic xlink:href="canmedaj01055-0011-b" xlink:role="9"></graphic></fig><fig id="F4"><label>Fig. 4</label><graphic xlink:href="canmedaj01055-0011-c" xlink:role="9"></graphic></fig><fig id="F5"><label>Fig. 5</label><graphic xlink:href="canmedaj01055-0011-d" xlink:role="9"></graphic></fig><fig id="F6"><label>Fig. 6</label><graphic xlink:href="canmedaj01055-0012-a" xlink:role="10"></graphic></fig><fig id="F7"><label>Fig. 7</label><graphic xlink:href="canmedaj01055-0014-a" xlink:role="12"></graphic></fig><fig id="F8"><label>Fig. 8</label><graphic xlink:href="canmedaj01055-0014-b" xlink:role="12"></graphic></fig><fig id="F9"><label>Fig. 9</label><graphic xlink:href="canmedaj01055-0014-c" xlink:role="12"></graphic></fig><fig id="F10"><label>Fig. 10</label><graphic xlink:href="canmedaj01055-0015-a" xlink:role="13"></graphic></fig><fig id="F11"><label>Fig. 11</label><graphic xlink:href="canmedaj01055-0015-b" xlink:role="13"></graphic></fig><fig id="F12"><label>Fig. 12</label><graphic xlink:href="canmedaj01055-0016-a" xlink:role="14"></graphic></fig><fig id="F13"><label>Fig. 13</label><graphic xlink:href="canmedaj01055-0017-a" xlink:role="15"></graphic></fig><fig id="F14"><label>Fig. 14</label><graphic xlink:href="canmedaj01055-0018-a" xlink:role="16"></graphic></fig><fig id="F15"><label>Fig. 15</label><graphic xlink:href="canmedaj01055-0019-a" xlink:role="17"></graphic></fig><fig id="F16"><label>Fig. 16</label><graphic xlink:href="canmedaj01055-0020-a" xlink:role="18"></graphic></fig><fig id="F17"><label>Fig. 17</label><graphic xlink:href="canmedaj01055-0021-a" xlink:role="19"></graphic></fig><fig id="F18"><label>Fig. 18</label><graphic xlink:href="canmedaj01055-0022-a" xlink:role="20"></graphic></fig><fig id="F19"><label>Fig. 19</label><graphic xlink:href="canmedaj01055-0023-a" xlink:role="21"></graphic></fig></sec></div></front></TEI><pmc article-type="meeting-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Can Med Assoc J</journal-id><journal-title>Canadian Medical Association Journal</journal-title><issn pub-type="ppub">0008-4409</issn></journal-meta><article-meta><article-id pub-id-type="pmid">14182565</article-id><article-id pub-id-type="pmc">1927327</article-id><article-categories><subj-group subj-group-type="heading"><subject>Symposium on Inflammatory Disease of the Intestine</subject></subj-group></article-categories><title-group><article-title>Current Concepts of the Pathogenesis and Pathology of Inflammatory Lesions of the Intestine</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Shnitka</surname><given-names>Theodor K.</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><day>04</day><month>07</month><year>1964</year></pub-date><volume>91</volume><issue>1</issue><fpage>7</fpage><lpage>22</lpage><abstract><p>The histopathologic lesions of regional enteritis and ulcerative colitis, particularly in their early stages, are distinct and distinguishable, irrespective of the sites that are involved. Regional enteritis is characterized by lymphangiectasis, lymphedema, lymphoid hyperplasia, and granulomatous inflammation of the submucosal and subserosal layers of intestine, whereas chronic ulcerative colitis is an exudative, ulcerative disorder of the mucosal layer that commences with “crypt abscesses” and only in its later stages progresses to deeper coats of the wall.</p><p>Electron microscopy of a rectal biopsy from a juvenile patient with chronic ulcerative colitis for five years disclosed a labyrinthine system of clefts and compartments between columnar, mucosal epithelial cells. Regenerated colonic epithelial cells were of primitive, germinal type and featured a “vesicular” rather than a “goblet” pattern of mucus secretion. Clusters of small “clavate fimbriae” projected from the tips of microvilli. Each of these newly recognized substructures measured 30 to 60 mμ. in diameter, and was enclosed by a tri-laminar “unit membrane”, derived from the surface plasma membrane of the cell.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Fig. 1</label><graphic xlink:href="canmedaj01055-0010-a" xlink:role="8"></graphic></fig><fig id="F2"><label>Fig. 2</label><graphic xlink:href="canmedaj01055-0011-a" xlink:role="9"></graphic></fig><fig id="F3"><label>Fig. 3</label><graphic xlink:href="canmedaj01055-0011-b" xlink:role="9"></graphic></fig><fig id="F4"><label>Fig. 4</label><graphic xlink:href="canmedaj01055-0011-c" xlink:role="9"></graphic></fig><fig id="F5"><label>Fig. 5</label><graphic xlink:href="canmedaj01055-0011-d" xlink:role="9"></graphic></fig><fig id="F6"><label>Fig. 6</label><graphic xlink:href="canmedaj01055-0012-a" xlink:role="10"></graphic></fig><fig id="F7"><label>Fig. 7</label><graphic xlink:href="canmedaj01055-0014-a" xlink:role="12"></graphic></fig><fig id="F8"><label>Fig. 8</label><graphic xlink:href="canmedaj01055-0014-b" xlink:role="12"></graphic></fig><fig id="F9"><label>Fig. 9</label><graphic xlink:href="canmedaj01055-0014-c" xlink:role="12"></graphic></fig><fig id="F10"><label>Fig. 10</label><graphic xlink:href="canmedaj01055-0015-a" xlink:role="13"></graphic></fig><fig id="F11"><label>Fig. 11</label><graphic xlink:href="canmedaj01055-0015-b" xlink:role="13"></graphic></fig><fig id="F12"><label>Fig. 12</label><graphic xlink:href="canmedaj01055-0016-a" xlink:role="14"></graphic></fig><fig id="F13"><label>Fig. 13</label><graphic xlink:href="canmedaj01055-0017-a" xlink:role="15"></graphic></fig><fig id="F14"><label>Fig. 14</label><graphic xlink:href="canmedaj01055-0018-a" xlink:role="16"></graphic></fig><fig id="F15"><label>Fig. 15</label><graphic xlink:href="canmedaj01055-0019-a" xlink:role="17"></graphic></fig><fig id="F16"><label>Fig. 16</label><graphic xlink:href="canmedaj01055-0020-a" xlink:role="18"></graphic></fig><fig id="F17"><label>Fig. 17</label><graphic xlink:href="canmedaj01055-0021-a" xlink:role="19"></graphic></fig><fig id="F18"><label>Fig. 18</label><graphic xlink:href="canmedaj01055-0022-a" xlink:role="20"></graphic></fig><fig id="F19"><label>Fig. 19</label><graphic xlink:href="canmedaj01055-0023-a" xlink:role="21"></graphic></fig></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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