LymphedemaV1, Ncbi, Curation, bibRecord, 000E55

Characterization of Antibody Responses to Wolbachia Surface Protein in Humans with Lymphatic Filariasis

Identifieur interne : 000E55 ( Ncbi/Curation ); précédent : 000E54; suivant : 000E56

Characterization of Antibody Responses to Wolbachia Surface Protein in Humans with Lymphatic Filariasis

Auteurs : George A. Punkosdy ; David G. Addiss ; Patrick J. Lammie

Source :

Infection and Immunity [ 0019-9567 ] ; 2003.

RBID : PMC:187306

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antibactériens (sang), Antigènes bactériens (génétique), Brugia malayi (microbiologie), Cartographie épitopique, Facteurs temps, Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (microbiologie), Filariose lymphatique (parasitologie), Haïti, Humains, Hydrocèle (immunologie), Hydrocèle (microbiologie), Hydrocèle (parasitologie), Immunoglobuline G (sang), Mâle, Protéines bactériennes (génétique), Protéines bactériennes (immunologie), Protéines membranaires (génétique), Protéines membranaires (immunologie), Sujet âgé, Symbiose, Séquence d'acides aminés, Wolbachia (génétique), Wolbachia (immunologie), Wolbachia (pathogénicité), Études cas-témoins.
MESH :
- génétique : Antigènes bactériens, Protéines bactériennes, Protéines membranaires, Wolbachia.
- immunologie : Filariose lymphatique, Hydrocèle, Protéines bactériennes, Protéines membranaires, Wolbachia.
- microbiologie : Brugia malayi, Filariose lymphatique, Hydrocèle.
- parasitologie : Filariose lymphatique, Hydrocèle.
- pathogénicité : Wolbachia.
- sang : Anticorps antibactériens, Immunoglobuline G.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Cartographie épitopique, Facteurs temps, Femelle, Haïti, Humains, Mâle, Sujet âgé, Symbiose, Séquence d'acides aminés, Études cas-témoins.
Wicri :
- geographic : Haïti.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Amino Acid Sequence, Animals, Antibodies, Bacterial (blood), Antigens, Bacterial (genetics), Bacterial Proteins (genetics), Bacterial Proteins (immunology), Brugia malayi (microbiology), Case-Control Studies, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (microbiology), Elephantiasis, Filarial (parasitology), Epitope Mapping, Female, Haiti, Humans, Immunoglobulin G (blood), Male, Membrane Proteins (genetics), Membrane Proteins (immunology), Middle Aged, Symbiosis, Testicular Hydrocele (immunology), Testicular Hydrocele (microbiology), Testicular Hydrocele (parasitology), Time Factors, Wolbachia (genetics), Wolbachia (immunology), Wolbachia (pathogenicity).
MESH :
- chemical , blood : Antibodies, Bacterial, Immunoglobulin G.
- chemical , genetics : Antigens, Bacterial, Bacterial Proteins, Membrane Proteins.
- chemical , immunology : Bacterial Proteins, Membrane Proteins.
- geographic : Haiti.
- genetics : Wolbachia.
- immunology : Elephantiasis, Filarial, Testicular Hydrocele, Wolbachia.
- microbiology : Brugia malayi, Elephantiasis, Filarial, Testicular Hydrocele.
- parasitology : Elephantiasis, Filarial, Testicular Hydrocele.
- pathogenicity : Wolbachia.
- Adolescent, Adult, Aged, Amino Acid Sequence, Animals, Case-Control Studies, Epitope Mapping, Female, Humans, Male, Middle Aged, Symbiosis, Time Factors.

Abstract

Symbiotic Wolbachia organisms of filarial nematodes have received much attention as possible chemotherapy targets and disease-causing organisms. In order to further investigate the association between anti-Wolbachia immune responses and chronic filarial disease in humans, antibody responses to Wolbachia surface protein (WSP) were assayed in serum samples collected from 232 individuals living in Leogane, Haiti, an area where Wuchereria bancrofti infection is endemic, and from 67 North Americans with no history of lymphatic filariasis. As opposed to antifilarial antibody responses, which were largely influenced by the patient's infection status, the prevalence and levels of anti-WSP immunoglobulin G (IgG) antibodies among individuals with lymphedema or hydrocele were significantly greater than those in gender- and infection-matched individuals without disease. In at least one case, the anti-WSP IgG response was coincident with the onset of lymphedema development, and among anti-WSP-positive women with lymphedema, anti-WSP IgG levels were negatively correlated with the duration of lymphedema. The presence of anti-WSP IgG was also associated with the severity of inguinal adenopathy among men with hydrocele. In addition to the presence of anti-WSP antibodies among Haitians, 15 of 67 (22%) serum samples collected from individuals from North America, where filariasis is not endemic, were also positive for anti-WSP antibodies. In comparison to those from Haitians, anti-WSP antibodies from North Americans primarily recognized a distinct region of WSP located within the highly conserved second transmembrane domain. The results of this study demonstrate that anti-WSP antibody responses are associated with the presence of chronic filarial morbidity and not filarial infection status in humans and suggest that WSP should be further studied as a potential trigger for the development of filarial disease.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187306

DOI: 10.1128/IAI.71.9.5104-5114.2003
PubMed: 12933853
PubMed Central: 187306

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PMC:187306

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Antibodies, Bacterial (blood)</term>
<term>Antigens, Bacterial (genetics)</term>
<term>Bacterial Proteins (genetics)</term>
<term>Bacterial Proteins (immunology)</term>
<term>Brugia malayi (microbiology)</term>
<term>Case-Control Studies</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Elephantiasis, Filarial (microbiology)</term>
<term>Elephantiasis, Filarial (parasitology)</term>
<term>Epitope Mapping</term>
<term>Female</term>
<term>Haiti</term>
<term>Humans</term>
<term>Immunoglobulin G (blood)</term>
<term>Male</term>
<term>Membrane Proteins (genetics)</term>
<term>Membrane Proteins (immunology)</term>
<term>Middle Aged</term>
<term>Symbiosis</term>
<term>Testicular Hydrocele (immunology)</term>
<term>Testicular Hydrocele (microbiology)</term>
<term>Testicular Hydrocele (parasitology)</term>
<term>Time Factors</term>
<term>Wolbachia (genetics)</term>
<term>Wolbachia (immunology)</term>
<term>Wolbachia (pathogenicity)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Anticorps antibactériens (sang)</term>
<term>Antigènes bactériens (génétique)</term>
<term>Brugia malayi (microbiologie)</term>
<term>Cartographie épitopique</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Filariose lymphatique (microbiologie)</term>
<term>Filariose lymphatique (parasitologie)</term>
<term>Haïti</term>
<term>Humains</term>
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<term>Hydrocèle (microbiologie)</term>
<term>Hydrocèle (parasitologie)</term>
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<term>Mâle</term>
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<term>Sujet âgé</term>
<term>Symbiose</term>
<term>Séquence d'acides aminés</term>
<term>Wolbachia (génétique)</term>
<term>Wolbachia (immunologie)</term>
<term>Wolbachia (pathogénicité)</term>
<term>Études cas-témoins</term>
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<term>Bacterial Proteins</term>
<term>Membrane Proteins</term>
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<term>Membrane Proteins</term>
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<term>Protéines membranaires</term>
<term>Wolbachia</term>
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<term>Hydrocèle</term>
<term>Protéines bactériennes</term>
<term>Protéines membranaires</term>
<term>Wolbachia</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term>
<term>Testicular Hydrocele</term>
<term>Wolbachia</term>
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<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Brugia malayi</term>
<term>Filariose lymphatique</term>
<term>Hydrocèle</term>
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<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Brugia malayi</term>
<term>Elephantiasis, Filarial</term>
<term>Testicular Hydrocele</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term>
<term>Hydrocèle</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term>
<term>Testicular Hydrocele</term>
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<term>Adult</term>
<term>Aged</term>
<term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Case-Control Studies</term>
<term>Epitope Mapping</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Symbiosis</term>
<term>Time Factors</term>
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<term>Adulte d'âge moyen</term>
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<front><div type="abstract" xml:lang="en"><p>Symbiotic <italic>Wolbachia</italic>
 organisms of filarial nematodes have received much attention as possible chemotherapy targets and disease-causing organisms. In order to further investigate the association between anti-<italic>Wolbachia</italic>
 immune responses and chronic filarial disease in humans, antibody responses to <italic>Wolbachia</italic>
 surface protein (WSP) were assayed in serum samples collected from 232 individuals living in Leogane, Haiti, an area where <italic>Wuchereria bancrofti</italic>
 infection is endemic, and from 67 North Americans with no history of lymphatic filariasis. As opposed to antifilarial antibody responses, which were largely influenced by the patient's infection status, the prevalence and levels of anti-WSP immunoglobulin G (IgG) antibodies among individuals with lymphedema or hydrocele were significantly greater than those in gender- and infection-matched individuals without disease. In at least one case, the anti-WSP IgG response was coincident with the onset of lymphedema development, and among anti-WSP-positive women with lymphedema, anti-WSP IgG levels were negatively correlated with the duration of lymphedema. The presence of anti-WSP IgG was also associated with the severity of inguinal adenopathy among men with hydrocele. In addition to the presence of anti-WSP antibodies among Haitians, 15 of 67 (22%) serum samples collected from individuals from North America, where filariasis is not endemic, were also positive for anti-WSP antibodies. In comparison to those from Haitians, anti-WSP antibodies from North Americans primarily recognized a distinct region of WSP located within the highly conserved second transmembrane domain. The results of this study demonstrate that anti-WSP antibody responses are associated with the presence of chronic filarial morbidity and not filarial infection status in humans and suggest that WSP should be further studied as a potential trigger for the development of filarial disease.</p>
</div>
</front>
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Characterization of Antibody Responses to Wolbachia Surface Protein in Humans with Lymphatic Filariasis

Characterization of Antibody Responses to Wolbachia Surface Protein in Humans with Lymphatic Filariasis

Source :

Descripteurs français

English descriptors

Abstract

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