Characterization of antibody responses to Wolbachia surface protein in humans with lymphatic filariasis.
Identifieur interne : 004189 ( PubMed/Curation ); précédent : 004188; suivant : 004190Characterization of antibody responses to Wolbachia surface protein in humans with lymphatic filariasis.
Auteurs : George A. Punkosdy [États-Unis] ; David G. Addiss ; Patrick J. LammieSource :
- Infection and immunity [ 0019-9567 ] ; 2003.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antibactériens (sang), Antigènes bactériens (génétique), Brugia malayi (microbiologie), Cartographie épitopique, Facteurs temps, Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (microbiologie), Filariose lymphatique (parasitologie), Haïti, Humains, Hydrocèle (immunologie), Hydrocèle (microbiologie), Hydrocèle (parasitologie), Immunoglobuline G (sang), Mâle, Protéines bactériennes (génétique), Protéines bactériennes (immunologie), Protéines membranaires (génétique), Protéines membranaires (immunologie), Sujet âgé, Symbiose, Séquence d'acides aminés, Wolbachia (génétique), Wolbachia (immunologie), Wolbachia (pathogénicité), Études cas-témoins.
- MESH :
- génétique : Antigènes bactériens, Protéines bactériennes, Protéines membranaires, Wolbachia.
- immunologie : Filariose lymphatique, Hydrocèle, Protéines bactériennes, Protéines membranaires, Wolbachia.
- microbiologie : Brugia malayi, Filariose lymphatique, Hydrocèle.
- parasitologie : Filariose lymphatique, Hydrocèle.
- pathogénicité : Wolbachia.
- sang : Anticorps antibactériens, Immunoglobuline G.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Cartographie épitopique, Facteurs temps, Femelle, Haïti, Humains, Mâle, Sujet âgé, Symbiose, Séquence d'acides aminés, Études cas-témoins.
- Wicri :
- geographic : Haïti.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Amino Acid Sequence, Animals, Antibodies, Bacterial (blood), Antigens, Bacterial (genetics), Bacterial Proteins (genetics), Bacterial Proteins (immunology), Brugia malayi (microbiology), Case-Control Studies, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (microbiology), Elephantiasis, Filarial (parasitology), Epitope Mapping, Female, Haiti, Humans, Immunoglobulin G (blood), Male, Membrane Proteins (genetics), Membrane Proteins (immunology), Middle Aged, Symbiosis, Testicular Hydrocele (immunology), Testicular Hydrocele (microbiology), Testicular Hydrocele (parasitology), Time Factors, Wolbachia (genetics), Wolbachia (immunology), Wolbachia (pathogenicity).
- MESH :
- chemical , blood : Antibodies, Bacterial, Immunoglobulin G.
- chemical , genetics : Antigens, Bacterial, Bacterial Proteins, Membrane Proteins.
- chemical , immunology : Bacterial Proteins, Membrane Proteins.
- geographic : Haiti.
- genetics : Wolbachia.
- immunology : Elephantiasis, Filarial, Testicular Hydrocele, Wolbachia.
- microbiology : Brugia malayi, Elephantiasis, Filarial, Testicular Hydrocele.
- parasitology : Elephantiasis, Filarial, Testicular Hydrocele.
- pathogenicity : Wolbachia.
- Adolescent, Adult, Aged, Amino Acid Sequence, Animals, Case-Control Studies, Epitope Mapping, Female, Humans, Male, Middle Aged, Symbiosis, Time Factors.
Abstract
Symbiotic Wolbachia organisms of filarial nematodes have received much attention as possible chemotherapy targets and disease-causing organisms. In order to further investigate the association between anti-Wolbachia immune responses and chronic filarial disease in humans, antibody responses to Wolbachia surface protein (WSP) were assayed in serum samples collected from 232 individuals living in Leogane, Haiti, an area where Wuchereria bancrofti infection is endemic, and from 67 North Americans with no history of lymphatic filariasis. As opposed to antifilarial antibody responses, which were largely influenced by the patient's infection status, the prevalence and levels of anti-WSP immunoglobulin G (IgG) antibodies among individuals with lymphedema or hydrocele were significantly greater than those in gender- and infection-matched individuals without disease. In at least one case, the anti-WSP IgG response was coincident with the onset of lymphedema development, and among anti-WSP-positive women with lymphedema, anti-WSP IgG levels were negatively correlated with the duration of lymphedema. The presence of anti-WSP IgG was also associated with the severity of inguinal adenopathy among men with hydrocele. In addition to the presence of anti-WSP antibodies among Haitians, 15 of 67 (22%) serum samples collected from individuals from North America, where filariasis is not endemic, were also positive for anti-WSP antibodies. In comparison to those from Haitians, anti-WSP antibodies from North Americans primarily recognized a distinct region of WSP located within the highly conserved second transmembrane domain. The results of this study demonstrate that anti-WSP antibody responses are associated with the presence of chronic filarial morbidity and not filarial infection status in humans and suggest that WSP should be further studied as a potential trigger for the development of filarial disease.
PubMed: 12933853
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Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Cartographie épitopique</term><term>Facteurs temps</term><term>Femelle</term><term>Haïti</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Symbiose</term><term>Séquence d'acides aminés</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Haïti</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Symbiotic Wolbachia organisms of filarial nematodes have received much attention as possible chemotherapy targets and disease-causing organisms. In order to further investigate the association between anti-Wolbachia immune responses and chronic filarial disease in humans, antibody responses to Wolbachia surface protein (WSP) were assayed in serum samples collected from 232 individuals living in Leogane, Haiti, an area where Wuchereria bancrofti infection is endemic, and from 67 North Americans with no history of lymphatic filariasis. As opposed to antifilarial antibody responses, which were largely influenced by the patient's infection status, the prevalence and levels of anti-WSP immunoglobulin G (IgG) antibodies among individuals with lymphedema or hydrocele were significantly greater than those in gender- and infection-matched individuals without disease. In at least one case, the anti-WSP IgG response was coincident with the onset of lymphedema development, and among anti-WSP-positive women with lymphedema, anti-WSP IgG levels were negatively correlated with the duration of lymphedema. The presence of anti-WSP IgG was also associated with the severity of inguinal adenopathy among men with hydrocele. In addition to the presence of anti-WSP antibodies among Haitians, 15 of 67 (22%) serum samples collected from individuals from North America, where filariasis is not endemic, were also positive for anti-WSP antibodies. In comparison to those from Haitians, anti-WSP antibodies from North Americans primarily recognized a distinct region of WSP located within the highly conserved second transmembrane domain. The results of this study demonstrate that anti-WSP antibody responses are associated with the presence of chronic filarial morbidity and not filarial infection status in humans and suggest that WSP should be further studied as a potential trigger for the development of filarial disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12933853</PMID><DateCreated><Year>2003</Year><Month>08</Month><Day>22</Day></DateCreated><DateCompleted><Year>2003</Year><Month>09</Month><Day>29</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0019-9567</ISSN><JournalIssue CitedMedium="Print"><Volume>71</Volume><Issue>9</Issue><PubDate><Year>2003</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Infection and immunity</Title><ISOAbbreviation>Infect. Immun.</ISOAbbreviation></Journal><ArticleTitle>Characterization of antibody responses to Wolbachia surface protein in humans with lymphatic filariasis.</ArticleTitle><Pagination><MedlinePgn>5104-14</MedlinePgn></Pagination><Abstract><AbstractText>Symbiotic Wolbachia organisms of filarial nematodes have received much attention as possible chemotherapy targets and disease-causing organisms. In order to further investigate the association between anti-Wolbachia immune responses and chronic filarial disease in humans, antibody responses to Wolbachia surface protein (WSP) were assayed in serum samples collected from 232 individuals living in Leogane, Haiti, an area where Wuchereria bancrofti infection is endemic, and from 67 North Americans with no history of lymphatic filariasis. As opposed to antifilarial antibody responses, which were largely influenced by the patient's infection status, the prevalence and levels of anti-WSP immunoglobulin G (IgG) antibodies among individuals with lymphedema or hydrocele were significantly greater than those in gender- and infection-matched individuals without disease. In at least one case, the anti-WSP IgG response was coincident with the onset of lymphedema development, and among anti-WSP-positive women with lymphedema, anti-WSP IgG levels were negatively correlated with the duration of lymphedema. The presence of anti-WSP IgG was also associated with the severity of inguinal adenopathy among men with hydrocele. In addition to the presence of anti-WSP antibodies among Haitians, 15 of 67 (22%) serum samples collected from individuals from North America, where filariasis is not endemic, were also positive for anti-WSP antibodies. In comparison to those from Haitians, anti-WSP antibodies from North Americans primarily recognized a distinct region of WSP located within the highly conserved second transmembrane domain. The results of this study demonstrate that anti-WSP antibody responses are associated with the presence of chronic filarial morbidity and not filarial infection status in humans and suggest that WSP should be further studied as a potential trigger for the development of filarial disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Punkosdy</LastName><ForeName>George A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Department of Cellular Biology, University of Georgia, Athens, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Addiss</LastName><ForeName>David G</ForeName><Initials>DG</Initials></Author><Author ValidYN="Y"><LastName>Lammie</LastName><ForeName>Patrick J</ForeName><Initials>PJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Infect Immun</MedlineTA><NlmUniqueID>0246127</NlmUniqueID><ISSNLinking>0019-9567</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000907">Antibodies, Bacterial</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000942">Antigens, Bacterial</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001426">Bacterial Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Insect Mol Biol. 2000 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