The effect of lymphatic oedema on the uptake of colloids to the lymph nodes.
Identifieur interne : 00BB78 ( Ncbi/Checkpoint ); précédent : 00BB77; suivant : 00BB79The effect of lymphatic oedema on the uptake of colloids to the lymph nodes.
Auteurs : A E Hawley [Royaume-Uni] ; L. Illum ; S S DavisSource :
- Biopharmaceutics & drug disposition [ 0142-2782 ] ; 1998.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Lymphoedème, Noeuds lymphatiques.
- pharmacocinétique : Colloïdes.
- Animaux, Carragénane, Lymphoedème, Microsphères, Mâle, Noeuds lymphatiques, Rat Wistar, Rats, Répartition dans les tissus, Taille de particule.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacokinetics : Colloids.
- chemical : Carrageenan.
- chemically induced : Lymphedema.
- drug effects : Lymph Nodes.
- metabolism : Lymph Nodes, Lymphedema.
- Animals, Male, Microspheres, Particle Size, Rats, Rats, Wistar, Tissue Distribution.
Abstract
The majority of pathological conditions of the lymphatic system can result in some degree of lymphoedema, which in turn causes a reduced rate of lymph flow. In some cases, such as when nodes are invaded by tumour metastases, blockage of the lymphatic vessels may occur. In order to investigate the effect of such pathology on nanosphere uptake in regional lymph nodes, the fate of model polystyrene nanospheres, surface modified with block co-polymers of the poloxamine series, was determined following subcutaneous administration in a rat model with lymphoedema (induced by the administration of lambda-carrageenan). A drastic reduction of injection site drainage and lymph node uptake of nanospheres was observed in the inflammation model compared to control animals. The observations suggest that biodegradable nanospheres based on these will be suitable for the detection of oedema in the lymphatic system.
PubMed: 9570003
Affiliations:
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pubmed:9570003Le document en format XML
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Illum</name></author><author><name sortKey="Davis, S S" sort="Davis, S S" uniqKey="Davis S" first="S S" last="Davis">S S Davis</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9570003</idno><idno type="pmid">9570003</idno><idno type="wicri:Area/PubMed/Corpus">004E99</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004E99</idno><idno type="wicri:Area/PubMed/Curation">004E99</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004E99</idno><idno type="wicri:Area/PubMed/Checkpoint">004E99</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004E99</idno><idno type="wicri:Area/Ncbi/Merge">00BB78</idno><idno type="wicri:Area/Ncbi/Curation">00BB78</idno><idno type="wicri:Area/Ncbi/Checkpoint">00BB78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The effect of lymphatic oedema on the uptake of colloids to the lymph nodes.</title><author><name sortKey="Hawley, A E" sort="Hawley, A E" uniqKey="Hawley A" first="A E" last="Hawley">A E Hawley</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pharmaceutical Sciences, University of Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pharmaceutical Sciences, University of Nottingham</wicri:regionArea><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName><orgName type="university">Université de Nottingham</orgName></affiliation></author><author><name sortKey="Illum, L" sort="Illum, L" uniqKey="Illum L" first="L" last="Illum">L. Illum</name></author><author><name sortKey="Davis, S S" sort="Davis, S S" uniqKey="Davis S" first="S S" last="Davis">S S Davis</name></author></analytic><series><title level="j">Biopharmaceutics & drug disposition</title><idno type="ISSN">0142-2782</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Carrageenan</term><term>Colloids (pharmacokinetics)</term><term>Lymph Nodes (drug effects)</term><term>Lymph Nodes (metabolism)</term><term>Lymphedema (chemically induced)</term><term>Lymphedema (metabolism)</term><term>Male</term><term>Microspheres</term><term>Particle Size</term><term>Rats</term><term>Rats, Wistar</term><term>Tissue Distribution</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Carragénane</term><term>Colloïdes (pharmacocinétique)</term><term>Lymphoedème ()</term><term>Lymphoedème (métabolisme)</term><term>Microsphères</term><term>Mâle</term><term>Noeuds lymphatiques ()</term><term>Noeuds lymphatiques (métabolisme)</term><term>Rat Wistar</term><term>Rats</term><term>Répartition dans les tissus</term><term>Taille de particule</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Colloids</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Carrageenan</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymph Nodes</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphoedème</term><term>Noeuds lymphatiques</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Colloïdes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Microspheres</term><term>Particle Size</term><term>Rats</term><term>Rats, Wistar</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Carragénane</term><term>Lymphoedème</term><term>Microsphères</term><term>Mâle</term><term>Noeuds lymphatiques</term><term>Rat Wistar</term><term>Rats</term><term>Répartition dans les tissus</term><term>Taille de particule</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The majority of pathological conditions of the lymphatic system can result in some degree of lymphoedema, which in turn causes a reduced rate of lymph flow. In some cases, such as when nodes are invaded by tumour metastases, blockage of the lymphatic vessels may occur. In order to investigate the effect of such pathology on nanosphere uptake in regional lymph nodes, the fate of model polystyrene nanospheres, surface modified with block co-polymers of the poloxamine series, was determined following subcutaneous administration in a rat model with lymphoedema (induced by the administration of lambda-carrageenan). A drastic reduction of injection site drainage and lymph node uptake of nanospheres was observed in the inflammation model compared to control animals. The observations suggest that biodegradable nanospheres based on these will be suitable for the detection of oedema in the lymphatic system.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Nottinghamshire</li></region><settlement><li>Nottingham</li></settlement><orgName><li>Université de Nottingham</li></orgName></list><tree><noCountry><name sortKey="Davis, S S" sort="Davis, S S" uniqKey="Davis S" first="S S" last="Davis">S S Davis</name><name sortKey="Illum, L" sort="Illum, L" uniqKey="Illum L" first="L" last="Illum">L. Illum</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hawley, A E" sort="Hawley, A E" uniqKey="Hawley A" first="A E" last="Hawley">A E Hawley</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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