The effect of lymphatic oedema on the uptake of colloids to the lymph nodes.
Identifieur interne : 004E99 ( PubMed/Corpus ); précédent : 004E98; suivant : 004F00The effect of lymphatic oedema on the uptake of colloids to the lymph nodes.
Auteurs : A E Hawley ; L. Illum ; S S DavisSource :
- Biopharmaceutics & drug disposition [ 0142-2782 ] ; 1998.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacokinetics : Colloids.
- chemical : Carrageenan.
- chemically induced : Lymphedema.
- drug effects : Lymph Nodes.
- metabolism : Lymph Nodes, Lymphedema.
- Animals, Male, Microspheres, Particle Size, Rats, Rats, Wistar, Tissue Distribution.
Abstract
The majority of pathological conditions of the lymphatic system can result in some degree of lymphoedema, which in turn causes a reduced rate of lymph flow. In some cases, such as when nodes are invaded by tumour metastases, blockage of the lymphatic vessels may occur. In order to investigate the effect of such pathology on nanosphere uptake in regional lymph nodes, the fate of model polystyrene nanospheres, surface modified with block co-polymers of the poloxamine series, was determined following subcutaneous administration in a rat model with lymphoedema (induced by the administration of lambda-carrageenan). A drastic reduction of injection site drainage and lymph node uptake of nanospheres was observed in the inflammation model compared to control animals. The observations suggest that biodegradable nanospheres based on these will be suitable for the detection of oedema in the lymphatic system.
PubMed: 9570003
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pubmed:9570003Le document en format XML
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Illum</name></author><author><name sortKey="Davis, S S" sort="Davis, S S" uniqKey="Davis S" first="S S" last="Davis">S S Davis</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9570003</idno><idno type="pmid">9570003</idno><idno type="wicri:Area/PubMed/Corpus">004E99</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004E99</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The effect of lymphatic oedema on the uptake of colloids to the lymph nodes.</title><author><name sortKey="Hawley, A E" sort="Hawley, A E" uniqKey="Hawley A" first="A E" last="Hawley">A E Hawley</name><affiliation><nlm:affiliation>Department of Pharmaceutical Sciences, University of Nottingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Illum, L" sort="Illum, L" uniqKey="Illum L" first="L" last="Illum">L. Illum</name></author><author><name sortKey="Davis, S S" sort="Davis, S S" uniqKey="Davis S" first="S S" last="Davis">S S Davis</name></author></analytic><series><title level="j">Biopharmaceutics & drug disposition</title><idno type="ISSN">0142-2782</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Carrageenan</term><term>Colloids (pharmacokinetics)</term><term>Lymph Nodes (drug effects)</term><term>Lymph Nodes (metabolism)</term><term>Lymphedema (chemically induced)</term><term>Lymphedema (metabolism)</term><term>Male</term><term>Microspheres</term><term>Particle Size</term><term>Rats</term><term>Rats, Wistar</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Colloids</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Carrageenan</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymph Nodes</term><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Microspheres</term><term>Particle Size</term><term>Rats</term><term>Rats, Wistar</term><term>Tissue Distribution</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The majority of pathological conditions of the lymphatic system can result in some degree of lymphoedema, which in turn causes a reduced rate of lymph flow. In some cases, such as when nodes are invaded by tumour metastases, blockage of the lymphatic vessels may occur. In order to investigate the effect of such pathology on nanosphere uptake in regional lymph nodes, the fate of model polystyrene nanospheres, surface modified with block co-polymers of the poloxamine series, was determined following subcutaneous administration in a rat model with lymphoedema (induced by the administration of lambda-carrageenan). A drastic reduction of injection site drainage and lymph node uptake of nanospheres was observed in the inflammation model compared to control animals. The observations suggest that biodegradable nanospheres based on these will be suitable for the detection of oedema in the lymphatic system.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9570003</PMID><DateCreated><Year>1998</Year><Month>06</Month><Day>08</Day></DateCreated><DateCompleted><Year>1998</Year><Month>06</Month><Day>08</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0142-2782</ISSN><JournalIssue CitedMedium="Print"><Volume>19</Volume><Issue>3</Issue><PubDate><Year>1998</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Biopharmaceutics & drug disposition</Title><ISOAbbreviation>Biopharm Drug Dispos</ISOAbbreviation></Journal><ArticleTitle>The effect of lymphatic oedema on the uptake of colloids to the lymph nodes.</ArticleTitle><Pagination><MedlinePgn>193-7</MedlinePgn></Pagination><Abstract><AbstractText>The majority of pathological conditions of the lymphatic system can result in some degree of lymphoedema, which in turn causes a reduced rate of lymph flow. In some cases, such as when nodes are invaded by tumour metastases, blockage of the lymphatic vessels may occur. In order to investigate the effect of such pathology on nanosphere uptake in regional lymph nodes, the fate of model polystyrene nanospheres, surface modified with block co-polymers of the poloxamine series, was determined following subcutaneous administration in a rat model with lymphoedema (induced by the administration of lambda-carrageenan). A drastic reduction of injection site drainage and lymph node uptake of nanospheres was observed in the inflammation model compared to control animals. The observations suggest that biodegradable nanospheres based on these will be suitable for the detection of oedema in the lymphatic system.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hawley</LastName><ForeName>A E</ForeName><Initials>AE</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences, University of Nottingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Illum</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Davis</LastName><ForeName>S S</ForeName><Initials>SS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Biopharm Drug Dispos</MedlineTA><NlmUniqueID>7911226</NlmUniqueID><ISSNLinking>0142-2782</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003102">Colloids</NameOfSubstance></Chemical><Chemical><RegistryNumber>9000-07-1</RegistryNumber><NameOfSubstance UI="D002351">Carrageenan</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002351" MajorTopicYN="N">Carrageenan</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003102" MajorTopicYN="N">Colloids</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008863" MajorTopicYN="N">Microspheres</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010316" MajorTopicYN="N">Particle Size</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014018" MajorTopicYN="N">Tissue Distribution</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year><Month>5</Month><Day>7</Day><Hour>2</Hour><Minute>2</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2000</Year><Month>6</Month><Day>20</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1998</Year><Month>5</Month><Day>7</Day><Hour>2</Hour><Minute>2</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9570003</ArticleId><ArticleId IdType="pii">10.1002/(SICI)1099-081X(199804)19:3<193::AID-BDD88>3.0.CO;2-V</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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