Og4C3 circulating antigen: a marker of infection and adult worm burden in Wuchereria bancrofti filariasis.
Identifieur interne : 00B359 ( Ncbi/Checkpoint ); précédent : 00B358; suivant : 00B360Og4C3 circulating antigen: a marker of infection and adult worm burden in Wuchereria bancrofti filariasis.
Auteurs : S. Chanteau [Polynésie française] ; J P Moulia-Pelat ; P. Glaziou ; N L Nguyen ; P. Luquiaud ; C. Plichart ; P M Martin ; J L CartelSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 1994.
Descripteurs français
- KwdFr :
- MESH :
- croissance et développement : Wuchereria bancrofti.
- immunologie : Filariose lymphatique, Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- sang : Antigènes d'helminthe.
- Animaux, Femelle, Humains, Marqueurs biologiques, Mâle.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antigens, Helminth.
- growth & development : Wuchereria bancrofti.
- immunology : Elephantiasis, Filarial, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- Animals, Biomarkers, Female, Humans, Male.
Abstract
Og4C3 circulating filarial antigen was detected in the sera of 94.5% (259/274) of microfilaremic patients, 32% (239/751) of persons with presumption of filariasis, and 23% (11/48) of chronic filariasis patients. The antigen level was correlated with the microfilariae (Mf) density and patient age (P < .01). It remained stable in patients treated with microfilaricidal drugs. Og4C3 antigen, undetectable in Mf culture media, was demonstrated to be a rare somatic Mf antigen. It appears to be an excreted or secreted antigen from adult filaria. It could be used as a marker of infection and an indicator of adult worm burden.
PubMed: 8014511
Affiliations:
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Plichart</name></author><author><name sortKey="Martin, P M" sort="Martin, P M" uniqKey="Martin P" first="P M" last="Martin">P M Martin</name></author><author><name sortKey="Cartel, J L" sort="Cartel, J L" uniqKey="Cartel J" first="J L" last="Cartel">J L Cartel</name></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="ISSN">0022-1899</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Helminth (blood)</term><term>Biomarkers</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Wuchereria bancrofti (growth & development)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes d'helminthe (sang)</term><term>Femelle</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Humains</term><term>Marqueurs biologiques</term><term>Mâle</term><term>Wuchereria bancrofti (croissance et développement)</term><term>Wuchereria bancrofti (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biomarkers</term><term>Female</term><term>Humans</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Marqueurs biologiques</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Og4C3 circulating filarial antigen was detected in the sera of 94.5% (259/274) of microfilaremic patients, 32% (239/751) of persons with presumption of filariasis, and 23% (11/48) of chronic filariasis patients. The antigen level was correlated with the microfilariae (Mf) density and patient age (P < .01). It remained stable in patients treated with microfilaricidal drugs. Og4C3 antigen, undetectable in Mf culture media, was demonstrated to be a rare somatic Mf antigen. It appears to be an excreted or secreted antigen from adult filaria. It could be used as a marker of infection and an indicator of adult worm burden.</div></front></TEI><affiliations><list><country><li>Polynésie française</li></country></list><tree><noCountry><name sortKey="Cartel, J L" sort="Cartel, J L" uniqKey="Cartel J" first="J L" last="Cartel">J L Cartel</name><name sortKey="Glaziou, P" sort="Glaziou, P" uniqKey="Glaziou P" first="P" last="Glaziou">P. Glaziou</name><name sortKey="Luquiaud, P" sort="Luquiaud, P" uniqKey="Luquiaud P" first="P" last="Luquiaud">P. Luquiaud</name><name sortKey="Martin, P M" sort="Martin, P M" uniqKey="Martin P" first="P M" last="Martin">P M Martin</name><name sortKey="Moulia Pelat, J P" sort="Moulia Pelat, J P" uniqKey="Moulia Pelat J" first="J P" last="Moulia-Pelat">J P Moulia-Pelat</name><name sortKey="Nguyen, N L" sort="Nguyen, N L" uniqKey="Nguyen N" first="N L" last="Nguyen">N L Nguyen</name><name sortKey="Plichart, C" sort="Plichart, C" uniqKey="Plichart C" first="C" last="Plichart">C. Plichart</name></noCountry><country name="Polynésie française"><noRegion><name sortKey="Chanteau, S" sort="Chanteau, S" uniqKey="Chanteau S" first="S" last="Chanteau">S. Chanteau</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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