Og4C3 circulating antigen: a marker of infection and adult worm burden in Wuchereria bancrofti filariasis.
Identifieur interne : 00B359 ( Ncbi/Merge ); précédent : 00B358; suivant : 00B360Og4C3 circulating antigen: a marker of infection and adult worm burden in Wuchereria bancrofti filariasis.
Auteurs : S. Chanteau [Polynésie française] ; J P Moulia-Pelat ; P. Glaziou ; N L Nguyen ; P. Luquiaud ; C. Plichart ; P M Martin ; J L CartelSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 1994.
Descripteurs français
- KwdFr :
- MESH :
- croissance et développement : Wuchereria bancrofti.
- immunologie : Filariose lymphatique, Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- sang : Antigènes d'helminthe.
- Animaux, Femelle, Humains, Marqueurs biologiques, Mâle.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antigens, Helminth.
- growth & development : Wuchereria bancrofti.
- immunology : Elephantiasis, Filarial, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- Animals, Biomarkers, Female, Humans, Male.
Abstract
Og4C3 circulating filarial antigen was detected in the sera of 94.5% (259/274) of microfilaremic patients, 32% (239/751) of persons with presumption of filariasis, and 23% (11/48) of chronic filariasis patients. The antigen level was correlated with the microfilariae (Mf) density and patient age (P < .01). It remained stable in patients treated with microfilaricidal drugs. Og4C3 antigen, undetectable in Mf culture media, was demonstrated to be a rare somatic Mf antigen. It appears to be an excreted or secreted antigen from adult filaria. It could be used as a marker of infection and an indicator of adult worm burden.
PubMed: 8014511
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pubmed:8014511Le document en format XML
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<term>Antigens, Helminth (blood)</term>
<term>Biomarkers</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Elephantiasis, Filarial (parasitology)</term>
<term>Female</term>
<term>Humans</term>
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<term>Antigènes d'helminthe (sang)</term>
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<term>Filariose lymphatique (immunologie)</term>
<term>Filariose lymphatique (parasitologie)</term>
<term>Humains</term>
<term>Marqueurs biologiques</term>
<term>Mâle</term>
<term>Wuchereria bancrofti (croissance et développement)</term>
<term>Wuchereria bancrofti (immunologie)</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term>
<term>Wuchereria bancrofti</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term>
<term>Wuchereria bancrofti</term>
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<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term>
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<front><div type="abstract" xml:lang="en">Og4C3 circulating filarial antigen was detected in the sera of 94.5% (259/274) of microfilaremic patients, 32% (239/751) of persons with presumption of filariasis, and 23% (11/48) of chronic filariasis patients. The antigen level was correlated with the microfilariae (Mf) density and patient age (P < .01). It remained stable in patients treated with microfilaricidal drugs. Og4C3 antigen, undetectable in Mf culture media, was demonstrated to be a rare somatic Mf antigen. It appears to be an excreted or secreted antigen from adult filaria. It could be used as a marker of infection and an indicator of adult worm burden.</div>
</front>
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<Abstract><AbstractText>Og4C3 circulating filarial antigen was detected in the sera of 94.5% (259/274) of microfilaremic patients, 32% (239/751) of persons with presumption of filariasis, and 23% (11/48) of chronic filariasis patients. The antigen level was correlated with the microfilariae (Mf) density and patient age (P < .01). It remained stable in patients treated with microfilaricidal drugs. Og4C3 antigen, undetectable in Mf culture media, was demonstrated to be a rare somatic Mf antigen. It appears to be an excreted or secreted antigen from adult filaria. It could be used as a marker of infection and an indicator of adult worm burden.</AbstractText>
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