Potential use of IgG2-ELISA in the diagnosis of chronic elephantiasis and IgG4-ELISA in the follow-up of microfilaraemic patients infected with Brugia malayi.
Identifieur interne : 00B349 ( Ncbi/Checkpoint ); précédent : 00B348; suivant : 00B350Potential use of IgG2-ELISA in the diagnosis of chronic elephantiasis and IgG4-ELISA in the follow-up of microfilaraemic patients infected with Brugia malayi.
Auteurs : N. Rahmah ; A K Anuar ; R. Karim ; R. Mehdi ; B. Sinniah ; A W OmarSource :
- Biochemical and biophysical research communications [ 0006-291X ] ; 1994.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antihelminthe (), Anticorps antihelminthe (immunologie), Brugia malayi (immunologie), Filariose lymphatique (diagnostic), Filariose lymphatique (immunologie), Filariose lymphatique (sang), Humains, Immunoglobuline G (), Immunoglobuline G (immunologie), Maladie chronique, Test ELISA (), Études de suivi.
- MESH :
- diagnostic : Filariose lymphatique.
- immunologie : Anticorps antihelminthe, Brugia malayi, Filariose lymphatique, Immunoglobuline G.
- sang : Filariose lymphatique.
- Animaux, Anticorps antihelminthe, Humains, Immunoglobuline G, Maladie chronique, Test ELISA, Études de suivi.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (classification), Antibodies, Helminth (immunology), Brugia malayi (immunology), Chronic Disease, Elephantiasis, Filarial (blood), Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (immunology), Enzyme-Linked Immunosorbent Assay (methods), Follow-Up Studies, Humans, Immunoglobulin G (classification), Immunoglobulin G (immunology).
- MESH :
- chemical , classification : Antibodies, Helminth, Immunoglobulin G.
- chemical , immunology : Antibodies, Helminth, Immunoglobulin G.
- blood : Elephantiasis, Filarial.
- diagnosis : Elephantiasis, Filarial.
- immunology : Brugia malayi, Elephantiasis, Filarial.
- methods : Enzyme-Linked Immunosorbent Assay.
- Animals, Chronic Disease, Follow-Up Studies, Humans.
Abstract
Sera from fifty subjects with different presentations of Brugian filariasis and from common soil-transmitted helminth infections were tested for specific anti-filarial IgG and its subclasses. Anti-filarial IgG, IgG1 and IgG3 showed cross-reactivities with soil-transmitted helminthic infections and no significant differences in optical densities among the various groups of filarial patients. In comparison with other groups of subjects, IgG4-ELISA of sera from microfilaraemic patients and some previously microfilaraemic patients showed a significant increase in optical density readings, while IgG2-ELISA showed elevated optical density readings in sera of patients with chronic elephantiasis. Therefore IgG2-ELISA is potentially useful in the diagnosis of brugian chronic elephantiasis while IgG4-ELISA may be beneficial for follow-up diagnosis of treated microfilaraemic patients.
PubMed: 7999024
Affiliations:
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pubmed:7999024Le document en format XML
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<term>Antibodies, Helminth (classification)</term>
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<term>Brugia malayi (immunology)</term>
<term>Chronic Disease</term>
<term>Elephantiasis, Filarial (blood)</term>
<term>Elephantiasis, Filarial (diagnosis)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Enzyme-Linked Immunosorbent Assay (methods)</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Immunoglobulin G (classification)</term>
<term>Immunoglobulin G (immunology)</term>
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<term>Anticorps antihelminthe ()</term>
<term>Anticorps antihelminthe (immunologie)</term>
<term>Brugia malayi (immunologie)</term>
<term>Filariose lymphatique (diagnostic)</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Filariose lymphatique (sang)</term>
<term>Humains</term>
<term>Immunoglobuline G ()</term>
<term>Immunoglobuline G (immunologie)</term>
<term>Maladie chronique</term>
<term>Test ELISA ()</term>
<term>Études de suivi</term>
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<keywords scheme="MESH" type="chemical" qualifier="classification" xml:lang="en"><term>Antibodies, Helminth</term>
<term>Immunoglobulin G</term>
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<term>Immunoglobulin G</term>
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<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filariose lymphatique</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antihelminthe</term>
<term>Brugia malayi</term>
<term>Filariose lymphatique</term>
<term>Immunoglobuline G</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term>
<term>Elephantiasis, Filarial</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Chronic Disease</term>
<term>Follow-Up Studies</term>
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<term>Anticorps antihelminthe</term>
<term>Humains</term>
<term>Immunoglobuline G</term>
<term>Maladie chronique</term>
<term>Test ELISA</term>
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<front><div type="abstract" xml:lang="en">Sera from fifty subjects with different presentations of Brugian filariasis and from common soil-transmitted helminth infections were tested for specific anti-filarial IgG and its subclasses. Anti-filarial IgG, IgG1 and IgG3 showed cross-reactivities with soil-transmitted helminthic infections and no significant differences in optical densities among the various groups of filarial patients. In comparison with other groups of subjects, IgG4-ELISA of sera from microfilaraemic patients and some previously microfilaraemic patients showed a significant increase in optical density readings, while IgG2-ELISA showed elevated optical density readings in sera of patients with chronic elephantiasis. Therefore IgG2-ELISA is potentially useful in the diagnosis of brugian chronic elephantiasis while IgG4-ELISA may be beneficial for follow-up diagnosis of treated microfilaraemic patients.</div>
</front>
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<name sortKey="Karim, R" sort="Karim, R" uniqKey="Karim R" first="R" last="Karim">R. Karim</name>
<name sortKey="Mehdi, R" sort="Mehdi, R" uniqKey="Mehdi R" first="R" last="Mehdi">R. Mehdi</name>
<name sortKey="Omar, A W" sort="Omar, A W" uniqKey="Omar A" first="A W" last="Omar">A W Omar</name>
<name sortKey="Rahmah, N" sort="Rahmah, N" uniqKey="Rahmah N" first="N" last="Rahmah">N. Rahmah</name>
<name sortKey="Sinniah, B" sort="Sinniah, B" uniqKey="Sinniah B" first="B" last="Sinniah">B. Sinniah</name>
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