VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption
Identifieur interne : 007A11 ( Ncbi/Checkpoint ); précédent : 007A10; suivant : 007A12VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption
Auteurs : Harri Nurmi ; Pipsa Saharinen ; Georgia Zarkada ; Wei Zheng ; Marius R. Robciuc ; Kari Alitalo [Finlande]Source :
- EMBO Molecular Medicine [ 1757-4676 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Facteur de croissance endothéliale vasculaire de type C.
- métabolisme : Facteur de croissance endothéliale vasculaire de type C.
- physiologie : Intestins, Vaisseaux lymphatiques.
- Animaux, Délétion de gène, Métabolisme des lipides, Souris, Souris knockout.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Vascular Endothelial Growth Factor C.
- chemical , metabolism : Vascular Endothelial Growth Factor C.
- physiology : Intestines, Lymphatic Vessels.
- Animals, Gene Deletion, Lipid Metabolism, Mice, Mice, Knockout.
Abstract
Vascular endothelial growth factor C (VEGF-C) binding to its tyrosine kinase receptor VEGFR-3 drives lymphatic vessel growth during development and in pathological processes. Although the VEGF-C/VEGFR-3 pathway provides a target for treatment of cancer and lymphedema, the physiological functions of VEGF-C in adult vasculature are unknown. We show here that VEGF-C is necessary for perinatal lymphangiogenesis, but required for adult lymphatic vessel maintenance only in the intestine. Following
Url:
DOI: 10.15252/emmm.201505731
PubMed: 26459520
PubMed Central: 4644375
Affiliations:
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PMC:4644375Le document en format XML
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<term>Lipid Metabolism</term>
<term>Lymphatic Vessels (physiology)</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Vascular Endothelial Growth Factor C (genetics)</term>
<term>Vascular Endothelial Growth Factor C (metabolism)</term>
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<term>Délétion de gène</term>
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<term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term>
<term>Intestins (physiologie)</term>
<term>Métabolisme des lipides</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Vaisseaux lymphatiques (physiologie)</term>
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<term>Gene Deletion</term>
<term>Lipid Metabolism</term>
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<term>Mice, Knockout</term>
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<term>Délétion de gène</term>
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<front><div type="abstract" xml:lang="en"><p>Vascular endothelial growth factor C (VEGF-C) binding to its tyrosine kinase receptor VEGFR-3 drives lymphatic vessel growth during development and in pathological processes. Although the VEGF-C/VEGFR-3 pathway provides a target for treatment of cancer and lymphedema, the physiological functions of VEGF-C in adult vasculature are unknown. We show here that VEGF-C is necessary for perinatal lymphangiogenesis, but required for adult lymphatic vessel maintenance only in the intestine. Following <italic>Vegfc</italic>
gene deletion in adult mice, the intestinal lymphatic vessels, including the lacteal vessels, underwent gradual atrophy, which was aggravated when also <italic>Vegfd</italic>
was deleted. VEGF-C was expressed by a subset of smooth muscle cells adjacent to the lacteals in the villus and in the intestinal wall. The <italic>Vegfc-</italic>
deleted mice showed defective lipid absorption and increased fecal excretion of dietary cholesterol and fatty acids. When fed a high-fat diet, the <italic>Vegfc</italic>
-deficient mice were resistant to obesity and had improved glucose metabolism. Our findings indicate that the lymphangiogenic growth factors provide trophic and dynamic regulation of the intestinal lymphatic vasculature, which could be especially important in the dietary regulation of adiposity and cholesterol metabolism.</p>
</div>
</front>
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</TEI>
<affiliations><list><country><li>Finlande</li>
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<region><li>Uusimaa</li>
</region>
<settlement><li>Helsinki</li>
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<orgName><li>Université d'Helsinki</li>
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</record>
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