Growth factor therapy and lymph node graft for lymphedema.
Identifieur interne : 007150 ( Ncbi/Checkpoint ); précédent : 007149; suivant : 007151Growth factor therapy and lymph node graft for lymphedema.
Auteurs : Tomi V. Tervala [Finlande] ; Pauliina Hartiala [Finlande] ; Tuomas Tammela [Finlande] ; Mikko T. Visuri [Finlande] ; Seppo Yl Herttuala [Finlande] ; Kari Alitalo [Finlande] ; Anne M. Saarikko [Finlande]Source :
- The Journal of surgical research [ 1095-8673 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Facteur de croissance endothéliale vasculaire de type A (usage thérapeutique), Lymphangiogenèse, Lymphoedème (), Lymphoedème (physiopathologie), Lymphographie, Noeuds lymphatiques (transplantation), Récepteur-2 au facteur croissance endothéliale vasculaire (physiologie), Récepteur-3 au facteur croissance endothéliale vasculaire (physiologie), Souris.
- MESH :
- physiologie : Récepteur-2 au facteur croissance endothéliale vasculaire, Récepteur-3 au facteur croissance endothéliale vasculaire.
- physiopathologie : Lymphoedème.
- usage thérapeutique : Facteur de croissance endothéliale vasculaire de type A, Noeuds lymphatiques.
- Animaux, Lymphangiogenèse, Lymphoedème, Lymphographie, Souris.
English descriptors
- KwdEn :
- Animals, Lymph Nodes (transplantation), Lymphangiogenesis, Lymphedema (physiopathology), Lymphedema (therapy), Lymphography, Mice, Vascular Endothelial Growth Factor A (therapeutic use), Vascular Endothelial Growth Factor Receptor-2 (physiology), Vascular Endothelial Growth Factor Receptor-3 (physiology).
- MESH :
- chemical , physiology : Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factor Receptor-3.
- chemical , therapeutic use : Vascular Endothelial Growth Factor A.
- physiopathology : Lymphedema.
- therapy : Lymphedema.
- transplantation : Lymph Nodes.
- Animals, Lymphangiogenesis, Lymphography, Mice.
Abstract
Lymphedema still remains an unsolved problem. Secondary lymphedema often develops after cancer operations or radiation therapy, especially in breast cancer patients. Using a mouse model, we show here that the lymphatic network can be regenerated using lymphatic vascular growth factor therapy in combination with lymph node transfer.
DOI: 10.1016/j.jss.2015.02.031
PubMed: 25777822
Affiliations:
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<term>Lymphedema (therapy)</term>
<term>Lymphography</term>
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<term>Lymphographie</term>
<term>Noeuds lymphatiques (transplantation)</term>
<term>Récepteur-2 au facteur croissance endothéliale vasculaire (physiologie)</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire (physiologie)</term>
<term>Souris</term>
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<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Vascular Endothelial Growth Factor Receptor-2</term>
<term>Vascular Endothelial Growth Factor Receptor-3</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Récepteur-2 au facteur croissance endothéliale vasculaire</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire</term>
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<front><div type="abstract" xml:lang="en">Lymphedema still remains an unsolved problem. Secondary lymphedema often develops after cancer operations or radiation therapy, especially in breast cancer patients. Using a mouse model, we show here that the lymphatic network can be regenerated using lymphatic vascular growth factor therapy in combination with lymph node transfer.</div>
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<name sortKey="Saarikko, Anne M" sort="Saarikko, Anne M" uniqKey="Saarikko A" first="Anne M" last="Saarikko">Anne M. Saarikko</name>
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<name sortKey="Visuri, Mikko T" sort="Visuri, Mikko T" uniqKey="Visuri M" first="Mikko T" last="Visuri">Mikko T. Visuri</name>
<name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name>
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