[Axillary lymph node irradiation in breast cancer: state of the art].
Identifieur interne : 004C15 ( Ncbi/Checkpoint ); précédent : 004C14; suivant : 004C16[Axillary lymph node irradiation in breast cancer: state of the art].
Auteurs : Pierre Auberdiac [France] ; Cyrus Chargari ; Lysian Cartier ; Amira Zioueche ; Adrien Mélis ; Guy De Laroche ; Youlia Kirova ; Nicolas MagnéSource :
- Bulletin du cancer [ 1769-6917 ] ; 2012.
Descripteurs français
- KwdFr :
- Aisselle, Femelle, Humains, Irradiation ganglionnaire (), Irradiation ganglionnaire (effets indésirables), Lymphadénectomie (effets indésirables), Lymphoedème (étiologie), Métastase lymphatique, Pronostic, Radiothérapie adjuvante (), Récidive tumorale locale, Tumeurs du sein (), Tumeurs du sein (anatomopathologie), Tumeurs du sein (radiothérapie).
- MESH :
- anatomopathologie : Tumeurs du sein.
- effets indésirables : Irradiation ganglionnaire, Lymphadénectomie.
- radiothérapie : Tumeurs du sein.
- étiologie : Lymphoedème.
- Aisselle, Femelle, Humains, Irradiation ganglionnaire, Métastase lymphatique, Pronostic, Radiothérapie adjuvante, Récidive tumorale locale, Tumeurs du sein.
English descriptors
- KwdEn :
- Axilla, Breast Neoplasms (pathology), Breast Neoplasms (radiotherapy), Breast Neoplasms (surgery), Female, Humans, Lymph Node Excision (adverse effects), Lymphatic Irradiation (adverse effects), Lymphatic Irradiation (methods), Lymphatic Metastasis, Lymphedema (etiology), Neoplasm Recurrence, Local, Prognosis, Radiotherapy, Adjuvant (methods).
- MESH :
- adverse effects : Lymph Node Excision, Lymphatic Irradiation.
- etiology : Lymphedema.
- methods : Lymphatic Irradiation, Radiotherapy, Adjuvant.
- pathology : Breast Neoplasms.
- radiotherapy : Breast Neoplasms.
- surgery : Breast Neoplasms.
- Axilla, Female, Humans, Lymphatic Metastasis, Neoplasm Recurrence, Local, Prognosis.
Abstract
Place of axillary radiotherapy in the management of patients with breast cancer remains debated. While the prognostic value of axillary lymph node extension has been largely demonstrated, the benefit of axillary treatment is more uncertain. Large clinical trials having demonstrated the benefit of adjuvant radiotherapy in advanced breast cancer comprised large nodal irradiation, including axillary area. Analyzing the true benefit of axillary radiotherapy is rendered difficult by heterogeneity of series, particularly when focusing on the extent of lymph node dissection. Although adjuvant axillary radiotherapy is usually recommended in patients with insufficient lymph node dissection or with bulky axillary involvement, the prognosis in these patients remains poor by metastatic evolution and such strategy exposes to increased toxicity and functional sequels. Further assessments should better define the optimal indications and the true benefit of axillary radiotherapy.
DOI: 10.1684/bdc.2012.1548
PubMed: 22450226
Affiliations:
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pubmed:22450226Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Axilla</term>
<term>Breast Neoplasms (pathology)</term>
<term>Breast Neoplasms (radiotherapy)</term>
<term>Breast Neoplasms (surgery)</term>
<term>Female</term>
<term>Humans</term>
<term>Lymph Node Excision (adverse effects)</term>
<term>Lymphatic Irradiation (adverse effects)</term>
<term>Lymphatic Irradiation (methods)</term>
<term>Lymphatic Metastasis</term>
<term>Lymphedema (etiology)</term>
<term>Neoplasm Recurrence, Local</term>
<term>Prognosis</term>
<term>Radiotherapy, Adjuvant (methods)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Aisselle</term>
<term>Femelle</term>
<term>Humains</term>
<term>Irradiation ganglionnaire ()</term>
<term>Irradiation ganglionnaire (effets indésirables)</term>
<term>Lymphadénectomie (effets indésirables)</term>
<term>Lymphoedème (étiologie)</term>
<term>Métastase lymphatique</term>
<term>Pronostic</term>
<term>Radiothérapie adjuvante ()</term>
<term>Récidive tumorale locale</term>
<term>Tumeurs du sein ()</term>
<term>Tumeurs du sein (anatomopathologie)</term>
<term>Tumeurs du sein (radiothérapie)</term>
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<term>Lymphatic Irradiation</term>
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<term>Lymphadénectomie</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Lymphatic Irradiation</term>
<term>Radiotherapy, Adjuvant</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term>
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<keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Breast Neoplasms</term>
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<front><div type="abstract" xml:lang="en">Place of axillary radiotherapy in the management of patients with breast cancer remains debated. While the prognostic value of axillary lymph node extension has been largely demonstrated, the benefit of axillary treatment is more uncertain. Large clinical trials having demonstrated the benefit of adjuvant radiotherapy in advanced breast cancer comprised large nodal irradiation, including axillary area. Analyzing the true benefit of axillary radiotherapy is rendered difficult by heterogeneity of series, particularly when focusing on the extent of lymph node dissection. Although adjuvant axillary radiotherapy is usually recommended in patients with insufficient lymph node dissection or with bulky axillary involvement, the prognosis in these patients remains poor by metastatic evolution and such strategy exposes to increased toxicity and functional sequels. Further assessments should better define the optimal indications and the true benefit of axillary radiotherapy.</div>
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