Neonatal tolerance and patent filarial infection.
Identifieur interne : 002946 ( Ncbi/Checkpoint ); précédent : 002945; suivant : 002947Neonatal tolerance and patent filarial infection.
Auteurs : T V Rajan [États-Unis]Source :
- Trends in parasitology [ 1471-4922 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Brugia malayi (immunologie), Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Filariose lymphatique (épidémiologie), Humains, Iles du Pacifique (épidémiologie), Indonésie (épidémiologie), Interactions hôte-parasite, Maladies endémiques, Microfilaria (immunologie), Microfilaria (parasitologie), Mâle, Tolérance immunitaire, Wuchereria bancrofti (immunologie).
- MESH :
- immunologie : Brugia malayi, Filariose lymphatique, Microfilaria, Wuchereria bancrofti.
- parasitologie : Filariose lymphatique, Microfilaria.
- épidémiologie : Filariose lymphatique, Iles du Pacifique, Indonésie.
- Animaux, Femelle, Humains, Interactions hôte-parasite, Maladies endémiques, Mâle, Tolérance immunitaire.
English descriptors
- KwdEn :
- Animals, Brugia malayi (immunology), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Endemic Diseases, Female, Host-Parasite Interactions, Humans, Immune Tolerance, Indonesia (epidemiology), Male, Microfilariae (immunology), Microfilariae (parasitology), Pacific Islands (epidemiology), Wuchereria bancrofti (immunology).
- MESH :
- epidemiology : Elephantiasis, Filarial, Indonesia, Pacific Islands.
- immunology : Brugia malayi, Elephantiasis, Filarial, Microfilariae, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial, Microfilariae.
- Animals, Endemic Diseases, Female, Host-Parasite Interactions, Humans, Immune Tolerance, Male.
Abstract
Lymphatic filariasis occurs in endemic pockets. Patent infections with long-term, high-grade microfilaremia do not develop in nonendemic individuals. It is tempting to speculate that individuals with intact immune responses to filarial antigens are capable of dealing with filarial exposure without developing persistent infection. There are published data that support the idea that only those individuals who are impaired in their immune defense against these parasites owing to neonatal tolerization become productively infected with the filarial parasites. If the model is correct, there are profound implications for global eradication.
DOI: 10.1016/j.pt.2007.08.009
PubMed: 17888736
Affiliations:
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qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Elephantiasis, Filarial</term><term>Microfilariae</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Microfilaria</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Microfilariae</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Iles du Pacifique</term><term>Indonésie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Endemic Diseases</term><term>Female</term><term>Host-Parasite Interactions</term><term>Humans</term><term>Immune Tolerance</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Interactions hôte-parasite</term><term>Maladies endémiques</term><term>Mâle</term><term>Tolérance immunitaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphatic filariasis occurs in endemic pockets. Patent infections with long-term, high-grade microfilaremia do not develop in nonendemic individuals. It is tempting to speculate that individuals with intact immune responses to filarial antigens are capable of dealing with filarial exposure without developing persistent infection. There are published data that support the idea that only those individuals who are impaired in their immune defense against these parasites owing to neonatal tolerization become productively infected with the filarial parasites. If the model is correct, there are profound implications for global eradication.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Rajan, T V" sort="Rajan, T V" uniqKey="Rajan T" first="T V" last="Rajan">T V Rajan</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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