Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis.
Identifieur interne : 002494 ( Ncbi/Checkpoint ); précédent : 002493; suivant : 002495Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis.
Auteurs : S. Wongkamchai [Thaïlande] ; C. Rochjanawatsiriroj ; N. Monkong ; H. Nochot ; S. Loymek ; C. Jiraamornnimit ; S. Hunnangkul ; W. ChoochoteSource :
- Journal of helminthology [ 0022-149X ] ; 2006.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (analyse), Anticorps antihelminthe (sang), Brugia malayi (immunologie), Enfant, Facteurs de l'âge, Femelle, Filariose lymphatique (diagnostic), Filarioses (diagnostic), Filarioses (immunologie), Fèces (), Humains, Isotypes des immunoglobulines (analyse), Isotypes des immunoglobulines (sang), Maladies endémiques, Mâle, Sensibilité et spécificité, Spécificité des anticorps, Sujet âgé, Sujet âgé de 80 ans ou plus, Test ELISA (), Thaïlande, Éléphantiasis (diagnostic), Études cas-témoins.
- MESH :
- analyse : Anticorps antihelminthe, Isotypes des immunoglobulines.
- diagnostic : Filariose lymphatique, Filarioses, Éléphantiasis.
- immunologie : Brugia malayi, Filarioses.
- sang : Anticorps antihelminthe, Isotypes des immunoglobulines.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Facteurs de l'âge, Femelle, Fèces, Humains, Maladies endémiques, Mâle, Sensibilité et spécificité, Spécificité des anticorps, Sujet âgé, Sujet âgé de 80 ans ou plus, Test ELISA, Thaïlande, Études cas-témoins.
- Wicri :
- geographic : Thaïlande.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Animals, Antibodies, Helminth (analysis), Antibodies, Helminth (blood), Antibody Specificity, Brugia malayi (immunology), Case-Control Studies, Child, Elephantiasis (diagnosis), Elephantiasis, Filarial (diagnosis), Endemic Diseases, Enzyme-Linked Immunosorbent Assay (methods), Feces (chemistry), Female, Filariasis (diagnosis), Filariasis (immunology), Humans, Immunoglobulin Isotypes (analysis), Immunoglobulin Isotypes (blood), Male, Middle Aged, Sensitivity and Specificity, Thailand.
- MESH :
- chemical , analysis : Antibodies, Helminth, Immunoglobulin Isotypes.
- chemical , blood : Antibodies, Helminth, Immunoglobulin Isotypes.
- geographic : Thailand.
- chemistry : Feces.
- diagnosis : Elephantiasis, Elephantiasis, Filarial, Filariasis.
- immunology : Brugia malayi, Filariasis.
- methods : Enzyme-Linked Immunosorbent Assay.
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Animals, Antibody Specificity, Case-Control Studies, Child, Endemic Diseases, Female, Humans, Male, Middle Aged, Sensitivity and Specificity.
Abstract
To study the diagnostic significance of antifilarial IgG subclasses in the clinical spectrum of brugian filariasis, IgG1, IgG3 and IgG4 antifilarial antibodies were determined in an exposed population comprising 74 asymptomatic amicrofilaraemics, 30 microfilaraemics, 20 lymphangitis and 16 elephantiasis patients resident in Narathiwart province, an area endemic for Brugia malayi lymphatic filariasis in southern Thailand. The dominant isotype of antifilarial antibody was IgG4. A significantly higher percentage of individuals were positive for IgG1 in the microfilaraemic and lymphangitis groups compared with the elephantiasis and endemic normal patients, while a significantly higher positive rate of IgG3 was found in those with lymphangitis. The possible role of these isotypes for diagnostic purposes and the pattern of antibody response in various clinically manifesting groups are discussed.
PubMed: 17125545
Affiliations:
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Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Facteurs de l'âge</term><term>Femelle</term><term>Fèces</term><term>Humains</term><term>Maladies endémiques</term><term>Mâle</term><term>Sensibilité et spécificité</term><term>Spécificité des anticorps</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Test ELISA</term><term>Thaïlande</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Thaïlande</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To study the diagnostic significance of antifilarial IgG subclasses in the clinical spectrum of brugian filariasis, IgG1, IgG3 and IgG4 antifilarial antibodies were determined in an exposed population comprising 74 asymptomatic amicrofilaraemics, 30 microfilaraemics, 20 lymphangitis and 16 elephantiasis patients resident in Narathiwart province, an area endemic for Brugia malayi lymphatic filariasis in southern Thailand. The dominant isotype of antifilarial antibody was IgG4. A significantly higher percentage of individuals were positive for IgG1 in the microfilaraemic and lymphangitis groups compared with the elephantiasis and endemic normal patients, while a significantly higher positive rate of IgG3 was found in those with lymphangitis. The possible role of these isotypes for diagnostic purposes and the pattern of antibody response in various clinically manifesting groups are discussed.</div></front></TEI><affiliations><list><country><li>Thaïlande</li></country></list><tree><noCountry><name sortKey="Choochote, W" sort="Choochote, W" uniqKey="Choochote W" first="W" last="Choochote">W. Choochote</name><name sortKey="Hunnangkul, S" sort="Hunnangkul, S" uniqKey="Hunnangkul S" first="S" last="Hunnangkul">S. Hunnangkul</name><name sortKey="Jiraamornnimit, C" sort="Jiraamornnimit, C" uniqKey="Jiraamornnimit C" first="C" last="Jiraamornnimit">C. Jiraamornnimit</name><name sortKey="Loymek, S" sort="Loymek, S" uniqKey="Loymek S" first="S" last="Loymek">S. Loymek</name><name sortKey="Monkong, N" sort="Monkong, N" uniqKey="Monkong N" first="N" last="Monkong">N. Monkong</name><name sortKey="Nochot, H" sort="Nochot, H" uniqKey="Nochot H" first="H" last="Nochot">H. Nochot</name><name sortKey="Rochjanawatsiriroj, C" sort="Rochjanawatsiriroj, C" uniqKey="Rochjanawatsiriroj C" first="C" last="Rochjanawatsiriroj">C. Rochjanawatsiriroj</name></noCountry><country name="Thaïlande"><noRegion><name sortKey="Wongkamchai, S" sort="Wongkamchai, S" uniqKey="Wongkamchai S" first="S" last="Wongkamchai">S. Wongkamchai</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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