Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis.
Identifieur interne : 003817 ( PubMed/Corpus ); précédent : 003816; suivant : 003818Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis.
Auteurs : S. Wongkamchai ; C. Rochjanawatsiriroj ; N. Monkong ; H. Nochot ; S. Loymek ; C. Jiraamornnimit ; S. Hunnangkul ; W. ChoochoteSource :
- Journal of helminthology [ 0022-149X ] ; 2006.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Animals, Antibodies, Helminth (analysis), Antibodies, Helminth (blood), Antibody Specificity, Brugia malayi (immunology), Case-Control Studies, Child, Elephantiasis (diagnosis), Elephantiasis, Filarial (diagnosis), Endemic Diseases, Enzyme-Linked Immunosorbent Assay (methods), Feces (chemistry), Female, Filariasis (diagnosis), Filariasis (immunology), Humans, Immunoglobulin Isotypes (analysis), Immunoglobulin Isotypes (blood), Male, Middle Aged, Sensitivity and Specificity, Thailand.
- MESH :
- chemical , analysis : Antibodies, Helminth, Immunoglobulin Isotypes.
- chemical , blood : Antibodies, Helminth, Immunoglobulin Isotypes.
- geographic : Thailand.
- chemistry : Feces.
- diagnosis : Elephantiasis, Elephantiasis, Filarial, Filariasis.
- immunology : Brugia malayi, Filariasis.
- methods : Enzyme-Linked Immunosorbent Assay.
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Animals, Antibody Specificity, Case-Control Studies, Child, Endemic Diseases, Female, Humans, Male, Middle Aged, Sensitivity and Specificity.
Abstract
To study the diagnostic significance of antifilarial IgG subclasses in the clinical spectrum of brugian filariasis, IgG1, IgG3 and IgG4 antifilarial antibodies were determined in an exposed population comprising 74 asymptomatic amicrofilaraemics, 30 microfilaraemics, 20 lymphangitis and 16 elephantiasis patients resident in Narathiwart province, an area endemic for Brugia malayi lymphatic filariasis in southern Thailand. The dominant isotype of antifilarial antibody was IgG4. A significantly higher percentage of individuals were positive for IgG1 in the microfilaraemic and lymphangitis groups compared with the elephantiasis and endemic normal patients, while a significantly higher positive rate of IgG3 was found in those with lymphangitis. The possible role of these isotypes for diagnostic purposes and the pattern of antibody response in various clinically manifesting groups are discussed.
PubMed: 17125545
Links to Exploration step
pubmed:17125545Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis.</title>
<author><name sortKey="Wongkamchai, S" sort="Wongkamchai, S" uniqKey="Wongkamchai S" first="S" last="Wongkamchai">S. Wongkamchai</name>
<affiliation><nlm:affiliation>Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok-Noi, Bangkok, Thailand. siswk@mahidol.ac.th</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rochjanawatsiriroj, C" sort="Rochjanawatsiriroj, C" uniqKey="Rochjanawatsiriroj C" first="C" last="Rochjanawatsiriroj">C. Rochjanawatsiriroj</name>
</author>
<author><name sortKey="Monkong, N" sort="Monkong, N" uniqKey="Monkong N" first="N" last="Monkong">N. Monkong</name>
</author>
<author><name sortKey="Nochot, H" sort="Nochot, H" uniqKey="Nochot H" first="H" last="Nochot">H. Nochot</name>
</author>
<author><name sortKey="Loymek, S" sort="Loymek, S" uniqKey="Loymek S" first="S" last="Loymek">S. Loymek</name>
</author>
<author><name sortKey="Jiraamornnimit, C" sort="Jiraamornnimit, C" uniqKey="Jiraamornnimit C" first="C" last="Jiraamornnimit">C. Jiraamornnimit</name>
</author>
<author><name sortKey="Hunnangkul, S" sort="Hunnangkul, S" uniqKey="Hunnangkul S" first="S" last="Hunnangkul">S. Hunnangkul</name>
</author>
<author><name sortKey="Choochote, W" sort="Choochote, W" uniqKey="Choochote W" first="W" last="Choochote">W. Choochote</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2006">2006</date>
<idno type="RBID">pubmed:17125545</idno>
<idno type="pmid">17125545</idno>
<idno type="wicri:Area/PubMed/Corpus">003817</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003817</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis.</title>
<author><name sortKey="Wongkamchai, S" sort="Wongkamchai, S" uniqKey="Wongkamchai S" first="S" last="Wongkamchai">S. Wongkamchai</name>
<affiliation><nlm:affiliation>Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok-Noi, Bangkok, Thailand. siswk@mahidol.ac.th</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rochjanawatsiriroj, C" sort="Rochjanawatsiriroj, C" uniqKey="Rochjanawatsiriroj C" first="C" last="Rochjanawatsiriroj">C. Rochjanawatsiriroj</name>
</author>
<author><name sortKey="Monkong, N" sort="Monkong, N" uniqKey="Monkong N" first="N" last="Monkong">N. Monkong</name>
</author>
<author><name sortKey="Nochot, H" sort="Nochot, H" uniqKey="Nochot H" first="H" last="Nochot">H. Nochot</name>
</author>
<author><name sortKey="Loymek, S" sort="Loymek, S" uniqKey="Loymek S" first="S" last="Loymek">S. Loymek</name>
</author>
<author><name sortKey="Jiraamornnimit, C" sort="Jiraamornnimit, C" uniqKey="Jiraamornnimit C" first="C" last="Jiraamornnimit">C. Jiraamornnimit</name>
</author>
<author><name sortKey="Hunnangkul, S" sort="Hunnangkul, S" uniqKey="Hunnangkul S" first="S" last="Hunnangkul">S. Hunnangkul</name>
</author>
<author><name sortKey="Choochote, W" sort="Choochote, W" uniqKey="Choochote W" first="W" last="Choochote">W. Choochote</name>
</author>
</analytic>
<series><title level="j">Journal of helminthology</title>
<idno type="ISSN">0022-149X</idno>
<imprint><date when="2006" type="published">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Animals</term>
<term>Antibodies, Helminth (analysis)</term>
<term>Antibodies, Helminth (blood)</term>
<term>Antibody Specificity</term>
<term>Brugia malayi (immunology)</term>
<term>Case-Control Studies</term>
<term>Child</term>
<term>Elephantiasis (diagnosis)</term>
<term>Elephantiasis, Filarial (diagnosis)</term>
<term>Endemic Diseases</term>
<term>Enzyme-Linked Immunosorbent Assay (methods)</term>
<term>Feces (chemistry)</term>
<term>Female</term>
<term>Filariasis (diagnosis)</term>
<term>Filariasis (immunology)</term>
<term>Humans</term>
<term>Immunoglobulin Isotypes (analysis)</term>
<term>Immunoglobulin Isotypes (blood)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Sensitivity and Specificity</term>
<term>Thailand</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Helminth</term>
<term>Immunoglobulin Isotypes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term>
<term>Immunoglobulin Isotypes</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Thailand</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Feces</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis</term>
<term>Elephantiasis, Filarial</term>
<term>Filariasis</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term>
<term>Filariasis</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Animals</term>
<term>Antibody Specificity</term>
<term>Case-Control Studies</term>
<term>Child</term>
<term>Endemic Diseases</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Sensitivity and Specificity</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">To study the diagnostic significance of antifilarial IgG subclasses in the clinical spectrum of brugian filariasis, IgG1, IgG3 and IgG4 antifilarial antibodies were determined in an exposed population comprising 74 asymptomatic amicrofilaraemics, 30 microfilaraemics, 20 lymphangitis and 16 elephantiasis patients resident in Narathiwart province, an area endemic for Brugia malayi lymphatic filariasis in southern Thailand. The dominant isotype of antifilarial antibody was IgG4. A significantly higher percentage of individuals were positive for IgG1 in the microfilaraemic and lymphangitis groups compared with the elephantiasis and endemic normal patients, while a significantly higher positive rate of IgG3 was found in those with lymphangitis. The possible role of these isotypes for diagnostic purposes and the pattern of antibody response in various clinically manifesting groups are discussed.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17125545</PMID>
<DateCreated><Year>2006</Year>
<Month>11</Month>
<Day>27</Day>
</DateCreated>
<DateCompleted><Year>2007</Year>
<Month>06</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2006</Year>
<Month>11</Month>
<Day>27</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-149X</ISSN>
<JournalIssue CitedMedium="Print"><Volume>80</Volume>
<Issue>4</Issue>
<PubDate><Year>2006</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Journal of helminthology</Title>
<ISOAbbreviation>J. Helminthol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis.</ArticleTitle>
<Pagination><MedlinePgn>363-7</MedlinePgn>
</Pagination>
<Abstract><AbstractText>To study the diagnostic significance of antifilarial IgG subclasses in the clinical spectrum of brugian filariasis, IgG1, IgG3 and IgG4 antifilarial antibodies were determined in an exposed population comprising 74 asymptomatic amicrofilaraemics, 30 microfilaraemics, 20 lymphangitis and 16 elephantiasis patients resident in Narathiwart province, an area endemic for Brugia malayi lymphatic filariasis in southern Thailand. The dominant isotype of antifilarial antibody was IgG4. A significantly higher percentage of individuals were positive for IgG1 in the microfilaraemic and lymphangitis groups compared with the elephantiasis and endemic normal patients, while a significantly higher positive rate of IgG3 was found in those with lymphangitis. The possible role of these isotypes for diagnostic purposes and the pattern of antibody response in various clinically manifesting groups are discussed.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wongkamchai</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok-Noi, Bangkok, Thailand. siswk@mahidol.ac.th</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rochjanawatsiriroj</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Monkong</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
</Author>
<Author ValidYN="Y"><LastName>Nochot</LastName>
<ForeName>H</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Loymek</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Jiraamornnimit</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hunnangkul</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Choochote</LastName>
<ForeName>W</ForeName>
<Initials>W</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Helminthol</MedlineTA>
<NlmUniqueID>2985115R</NlmUniqueID>
<ISSNLinking>0022-149X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007132">Immunoglobulin Isotypes</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000909" MajorTopicYN="N">Antibodies, Helminth</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000918" MajorTopicYN="N">Antibody Specificity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017178" MajorTopicYN="N">Brugia malayi</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004604" MajorTopicYN="N">Elephantiasis</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019353" MajorTopicYN="N">Endemic Diseases</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005243" MajorTopicYN="N">Feces</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005368" MajorTopicYN="N">Filariasis</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007132" MajorTopicYN="N">Immunoglobulin Isotypes</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013785" MajorTopicYN="N" Type="Geographic">Thailand</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year>
<Month>11</Month>
<Day>28</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2007</Year>
<Month>6</Month>
<Day>30</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2006</Year>
<Month>11</Month>
<Day>28</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">17125545</ArticleId>
<ArticleId IdType="pii">S0022149X06000527</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003817 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 003817 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:17125545 |texte= Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:17125545" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |