Primitive neuroectodermal tumor (PNET) of the urinary bladder.
Identifieur interne : 001790 ( Ncbi/Checkpoint ); précédent : 001789; suivant : 001791Primitive neuroectodermal tumor (PNET) of the urinary bladder.
Auteurs : Stefan Krüger [Allemagne] ; Hannelore Schmidt ; Ingo Kausch ; Andreas Böhle ; Hans-Jürgen Holzhausen ; Reiner Johannisson ; Alfred C. FellerSource :
- Pathology, research and practice [ 0344-0338 ] ; 2003.
Descripteurs français
- KwdFr :
- Antigène CD99, Antigènes CD (métabolisme), Coloration et marquage, Enolase (métabolisme), Humains, Hybridation d'acides nucléiques, Immunohistochimie (), Molécules d'adhérence cellulaire (métabolisme), Mâle, Sujet âgé, Tumeurs de la vessie urinaire (anatomopathologie), Tumeurs de la vessie urinaire (génétique), Tumeurs de la vessie urinaire (métabolisme), Tumeurs de la vessie urinaire (ultrastructure), Tumeurs neuroectodermiques primitives périphériques (anatomopathologie), Tumeurs neuroectodermiques primitives périphériques (génétique), Tumeurs neuroectodermiques primitives périphériques (métabolisme), Tumeurs neuroectodermiques primitives périphériques (ultrastructure).
- MESH :
- anatomopathologie : Tumeurs de la vessie urinaire, Tumeurs neuroectodermiques primitives périphériques.
- génétique : Tumeurs de la vessie urinaire, Tumeurs neuroectodermiques primitives périphériques.
- métabolisme : Antigènes CD, Enolase, Molécules d'adhérence cellulaire, Tumeurs de la vessie urinaire, Tumeurs neuroectodermiques primitives périphériques.
- Antigène CD99, Coloration et marquage, Humains, Hybridation d'acides nucléiques, Immunohistochimie, Mâle, Sujet âgé, Tumeurs de la vessie urinaire, Tumeurs neuroectodermiques primitives périphériques.
English descriptors
- KwdEn :
- Aged, Antigens, CD (metabolism), Antigens, CD99, Cell Adhesion Molecules (metabolism), Humans, Immunohistochemistry (methods), Male, Neuroectodermal Tumors, Primitive, Peripheral (genetics), Neuroectodermal Tumors, Primitive, Peripheral (metabolism), Neuroectodermal Tumors, Primitive, Peripheral (pathology), Neuroectodermal Tumors, Primitive, Peripheral (ultrastructure), Nucleic Acid Hybridization, Phosphopyruvate Hydratase (metabolism), Staining and Labeling, Urinary Bladder Neoplasms (genetics), Urinary Bladder Neoplasms (metabolism), Urinary Bladder Neoplasms (pathology), Urinary Bladder Neoplasms (ultrastructure).
- MESH :
- chemical , metabolism : Antigens, CD, Cell Adhesion Molecules, Phosphopyruvate Hydratase.
- genetics : Neuroectodermal Tumors, Primitive, Peripheral, Urinary Bladder Neoplasms.
- metabolism : Neuroectodermal Tumors, Primitive, Peripheral, Urinary Bladder Neoplasms.
- methods : Immunohistochemistry.
- pathology : Neuroectodermal Tumors, Primitive, Peripheral, Urinary Bladder Neoplasms.
- ultrastructure : Neuroectodermal Tumors, Primitive, Peripheral, Urinary Bladder Neoplasms.
- Aged, Antigens, CD99, Humans, Male, Nucleic Acid Hybridization, Staining and Labeling.
Abstract
We report on the clinical, morphologic, immunohistochemical, ultrastructural, and molecular cytogenetic features of a primitive neuroectodermal tumor (PNET) primarily arising in the urinary bladder. An 81-year-old man presented with lymphedema of the lower extremities, fatigue, and urge incontinence. Radiographically, a tumor filling the entire cavity of the urinary bladder and extending into the pelvic and retroperitoneal tissue was noted. Histology of tumor biopsies showed a highly cellular, focally necrotic small round-cell tumor with numerous mitoses and occasional rosette-like structures. The tumor cells displayed significant immunoreactivity for neuron-specific enolase (NSE) and the MIC2 gene product (CD99). Dense-core granules were detectable by electron microscopy. A molecular cytogenetic analysis using comparative genomic hybridization (CGH) revealed gains of the chromosomes 3p, 6, 8q, 12, 17q, and 21q. The patient died two weeks after diagnosis. To the best of our knowledge, this is the fifth reported case of a PNET of the urinary bladder, and the first that includes a molecular cytogenetic analysis based on CGH.
DOI: 10.1078/0344-0338-00492
PubMed: 14708642
Affiliations:
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An 81-year-old man presented with lymphedema of the lower extremities, fatigue, and urge incontinence. Radiographically, a tumor filling the entire cavity of the urinary bladder and extending into the pelvic and retroperitoneal tissue was noted. Histology of tumor biopsies showed a highly cellular, focally necrotic small round-cell tumor with numerous mitoses and occasional rosette-like structures. The tumor cells displayed significant immunoreactivity for neuron-specific enolase (NSE) and the MIC2 gene product (CD99). Dense-core granules were detectable by electron microscopy. A molecular cytogenetic analysis using comparative genomic hybridization (CGH) revealed gains of the chromosomes 3p, 6, 8q, 12, 17q, and 21q. The patient died two weeks after diagnosis. To the best of our knowledge, this is the fifth reported case of a PNET of the urinary bladder, and the first that includes a molecular cytogenetic analysis based on CGH.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Bohle, Andreas" sort="Bohle, Andreas" uniqKey="Bohle A" first="Andreas" last="Böhle">Andreas Böhle</name><name sortKey="Feller, Alfred C" sort="Feller, Alfred C" uniqKey="Feller A" first="Alfred C" last="Feller">Alfred C. Feller</name><name sortKey="Holzhausen, Hans Jurgen" sort="Holzhausen, Hans Jurgen" uniqKey="Holzhausen H" first="Hans-Jürgen" last="Holzhausen">Hans-Jürgen Holzhausen</name><name sortKey="Johannisson, Reiner" sort="Johannisson, Reiner" uniqKey="Johannisson R" first="Reiner" last="Johannisson">Reiner Johannisson</name><name sortKey="Kausch, Ingo" sort="Kausch, Ingo" uniqKey="Kausch I" first="Ingo" last="Kausch">Ingo Kausch</name><name sortKey="Schmidt, Hannelore" sort="Schmidt, Hannelore" uniqKey="Schmidt H" first="Hannelore" last="Schmidt">Hannelore Schmidt</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Kruger, Stefan" sort="Kruger, Stefan" uniqKey="Kruger S" first="Stefan" last="Krüger">Stefan Krüger</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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