Primitive neuroectodermal tumor (PNET) of the urinary bladder.
Identifieur interne : 004100 ( PubMed/Curation ); précédent : 004099; suivant : 004101Primitive neuroectodermal tumor (PNET) of the urinary bladder.
Auteurs : Stefan Krüger [Allemagne] ; Hannelore Schmidt ; Ingo Kausch ; Andreas Böhle ; Hans-Jürgen Holzhausen ; Reiner Johannisson ; Alfred C. FellerSource :
- Pathology, research and practice [ 0344-0338 ] ; 2003.
Descripteurs français
- KwdFr :
- Antigène CD99, Antigènes CD (métabolisme), Coloration et marquage, Enolase (métabolisme), Humains, Hybridation d'acides nucléiques, Immunohistochimie (), Molécules d'adhérence cellulaire (métabolisme), Mâle, Sujet âgé, Tumeurs de la vessie urinaire (anatomopathologie), Tumeurs de la vessie urinaire (génétique), Tumeurs de la vessie urinaire (métabolisme), Tumeurs de la vessie urinaire (ultrastructure), Tumeurs neuroectodermiques primitives périphériques (anatomopathologie), Tumeurs neuroectodermiques primitives périphériques (génétique), Tumeurs neuroectodermiques primitives périphériques (métabolisme), Tumeurs neuroectodermiques primitives périphériques (ultrastructure).
- MESH :
- anatomopathologie : Tumeurs de la vessie urinaire, Tumeurs neuroectodermiques primitives périphériques.
- génétique : Tumeurs de la vessie urinaire, Tumeurs neuroectodermiques primitives périphériques.
- métabolisme : Antigènes CD, Enolase, Molécules d'adhérence cellulaire, Tumeurs de la vessie urinaire, Tumeurs neuroectodermiques primitives périphériques.
- Antigène CD99, Coloration et marquage, Humains, Hybridation d'acides nucléiques, Immunohistochimie, Mâle, Sujet âgé, Tumeurs de la vessie urinaire, Tumeurs neuroectodermiques primitives périphériques.
English descriptors
- KwdEn :
- Aged, Antigens, CD (metabolism), Antigens, CD99, Cell Adhesion Molecules (metabolism), Humans, Immunohistochemistry (methods), Male, Neuroectodermal Tumors, Primitive, Peripheral (genetics), Neuroectodermal Tumors, Primitive, Peripheral (metabolism), Neuroectodermal Tumors, Primitive, Peripheral (pathology), Neuroectodermal Tumors, Primitive, Peripheral (ultrastructure), Nucleic Acid Hybridization, Phosphopyruvate Hydratase (metabolism), Staining and Labeling, Urinary Bladder Neoplasms (genetics), Urinary Bladder Neoplasms (metabolism), Urinary Bladder Neoplasms (pathology), Urinary Bladder Neoplasms (ultrastructure).
- MESH :
- chemical , metabolism : Antigens, CD, Cell Adhesion Molecules, Phosphopyruvate Hydratase.
- genetics : Neuroectodermal Tumors, Primitive, Peripheral, Urinary Bladder Neoplasms.
- metabolism : Neuroectodermal Tumors, Primitive, Peripheral, Urinary Bladder Neoplasms.
- methods : Immunohistochemistry.
- pathology : Neuroectodermal Tumors, Primitive, Peripheral, Urinary Bladder Neoplasms.
- ultrastructure : Neuroectodermal Tumors, Primitive, Peripheral, Urinary Bladder Neoplasms.
- Aged, Antigens, CD99, Humans, Male, Nucleic Acid Hybridization, Staining and Labeling.
Abstract
We report on the clinical, morphologic, immunohistochemical, ultrastructural, and molecular cytogenetic features of a primitive neuroectodermal tumor (PNET) primarily arising in the urinary bladder. An 81-year-old man presented with lymphedema of the lower extremities, fatigue, and urge incontinence. Radiographically, a tumor filling the entire cavity of the urinary bladder and extending into the pelvic and retroperitoneal tissue was noted. Histology of tumor biopsies showed a highly cellular, focally necrotic small round-cell tumor with numerous mitoses and occasional rosette-like structures. The tumor cells displayed significant immunoreactivity for neuron-specific enolase (NSE) and the MIC2 gene product (CD99). Dense-core granules were detectable by electron microscopy. A molecular cytogenetic analysis using comparative genomic hybridization (CGH) revealed gains of the chromosomes 3p, 6, 8q, 12, 17q, and 21q. The patient died two weeks after diagnosis. To the best of our knowledge, this is the fifth reported case of a PNET of the urinary bladder, and the first that includes a molecular cytogenetic analysis based on CGH.
DOI: 10.1078/0344-0338-00492
PubMed: 14708642
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An 81-year-old man presented with lymphedema of the lower extremities, fatigue, and urge incontinence. Radiographically, a tumor filling the entire cavity of the urinary bladder and extending into the pelvic and retroperitoneal tissue was noted. Histology of tumor biopsies showed a highly cellular, focally necrotic small round-cell tumor with numerous mitoses and occasional rosette-like structures. The tumor cells displayed significant immunoreactivity for neuron-specific enolase (NSE) and the MIC2 gene product (CD99). Dense-core granules were detectable by electron microscopy. A molecular cytogenetic analysis using comparative genomic hybridization (CGH) revealed gains of the chromosomes 3p, 6, 8q, 12, 17q, and 21q. The patient died two weeks after diagnosis. To the best of our knowledge, this is the fifth reported case of a PNET of the urinary bladder, and the first that includes a molecular cytogenetic analysis based on CGH.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">14708642</PMID><DateCreated><Year>2004</Year><Month>01</Month><Day>07</Day></DateCreated><DateCompleted><Year>2004</Year><Month>07</Month><Day>28</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0344-0338</ISSN><JournalIssue CitedMedium="Print"><Volume>199</Volume><Issue>11</Issue><PubDate><Year>2003</Year></PubDate></JournalIssue><Title>Pathology, research and practice</Title><ISOAbbreviation>Pathol. Res. Pract.</ISOAbbreviation></Journal><ArticleTitle>Primitive neuroectodermal tumor (PNET) of the urinary bladder.</ArticleTitle><Pagination><MedlinePgn>751-4</MedlinePgn></Pagination><Abstract><AbstractText>We report on the clinical, morphologic, immunohistochemical, ultrastructural, and molecular cytogenetic features of a primitive neuroectodermal tumor (PNET) primarily arising in the urinary bladder. An 81-year-old man presented with lymphedema of the lower extremities, fatigue, and urge incontinence. Radiographically, a tumor filling the entire cavity of the urinary bladder and extending into the pelvic and retroperitoneal tissue was noted. Histology of tumor biopsies showed a highly cellular, focally necrotic small round-cell tumor with numerous mitoses and occasional rosette-like structures. The tumor cells displayed significant immunoreactivity for neuron-specific enolase (NSE) and the MIC2 gene product (CD99). Dense-core granules were detectable by electron microscopy. A molecular cytogenetic analysis using comparative genomic hybridization (CGH) revealed gains of the chromosomes 3p, 6, 8q, 12, 17q, and 21q. The patient died two weeks after diagnosis. To the best of our knowledge, this is the fifth reported case of a PNET of the urinary bladder, and the first that includes a molecular cytogenetic analysis based on CGH.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Krüger</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Pathology, University of Lübeck, Germany. krueger@patho-mu-luebeck.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Hannelore</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Kausch</LastName><ForeName>Ingo</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Böhle</LastName><ForeName>Andreas</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Holzhausen</LastName><ForeName>Hans-Jürgen</ForeName><Initials>HJ</Initials></Author><Author ValidYN="Y"><LastName>Johannisson</LastName><ForeName>Reiner</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Feller</LastName><ForeName>Alfred C</ForeName><Initials>AC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Pathol Res Pract</MedlineTA><NlmUniqueID>7806109</NlmUniqueID><ISSNLinking>0344-0338</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015703">Antigens, CD</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000071443">Antigens, CD99</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C061828">CD99 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015815">Cell Adhesion Molecules</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 4.2.1.11</RegistryNumber><NameOfSubstance UI="D010751">Phosphopyruvate Hydratase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015703" MajorTopicYN="N">Antigens, CD</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000071443" MajorTopicYN="N">Antigens, CD99</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015815" MajorTopicYN="N">Cell Adhesion Molecules</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018241" MajorTopicYN="N">Neuroectodermal Tumors, Primitive, Peripheral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009693" MajorTopicYN="N">Nucleic Acid Hybridization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010751" MajorTopicYN="N">Phosphopyruvate Hydratase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013194" MajorTopicYN="N">Staining and Labeling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001749" MajorTopicYN="N">Urinary Bladder Neoplasms</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>1</Month><Day>8</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>7</Month><Day>29</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>1</Month><Day>8</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">14708642</ArticleId><ArticleId IdType="pii">S0344-0338(04)70490-2</ArticleId><ArticleId IdType="doi">10.1078/0344-0338-00492</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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