Compared efficacy of repeated annual and semi-annual doses of ivermectin and diethylcarbamazine for prevention of Wuchereria bancrofti filariasis in French Polynesia. Final evaluation.
Identifieur interne : 00DC37 ( Main/Merge ); précédent : 00DC36; suivant : 00DC38Compared efficacy of repeated annual and semi-annual doses of ivermectin and diethylcarbamazine for prevention of Wuchereria bancrofti filariasis in French Polynesia. Final evaluation.
Auteurs : J L Cartel [Polynésie française] ; A. Spiegel ; L. Nguyen Ngnoc ; R. Cardines ; R. Plichart ; P M Martin ; J F Roux ; J P Moulia-PelatSource :
- Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) [ 0177-2392 ] ; 1992.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Diéthylcarbamazine (administration et posologie), Diéthylcarbamazine (pharmacologie), Diéthylcarbamazine (usage thérapeutique), Filariose lymphatique (), Humains, Ivermectine (administration et posologie), Ivermectine (pharmacologie), Ivermectine (usage thérapeutique), Microfilaria (), Méthode en double aveugle, Polynésie, Porteur sain (traitement médicamenteux), Wuchereria bancrofti (), Études de suivi, Évaluation de médicament.
- MESH :
- administration et posologie : Diéthylcarbamazine, Ivermectine.
- pharmacologie : Diéthylcarbamazine, Ivermectine.
- traitement médicamenteux : Porteur sain.
- usage thérapeutique : Diéthylcarbamazine, Ivermectine.
- Adulte, Adulte d'âge moyen, Animaux, Filariose lymphatique, Humains, Microfilaria, Méthode en double aveugle, Polynésie, Wuchereria bancrofti, Études de suivi, Évaluation de médicament.
English descriptors
- KwdEn :
- Adult, Animals, Carrier State (drug therapy), Diethylcarbamazine (administration & dosage), Diethylcarbamazine (pharmacology), Diethylcarbamazine (therapeutic use), Double-Blind Method, Drug Evaluation, Elephantiasis, Filarial (prevention & control), Follow-Up Studies, Humans, Ivermectin (administration & dosage), Ivermectin (pharmacology), Ivermectin (therapeutic use), Microfilariae (drug effects), Middle Aged, Polynesia, Wuchereria bancrofti (drug effects).
- MESH :
- chemical , administration & dosage : Diethylcarbamazine, Ivermectin.
- drug effects : Microfilariae, Wuchereria bancrofti.
- drug therapy : Carrier State.
- chemical , pharmacology : Diethylcarbamazine, Ivermectin.
- prevention & control : Elephantiasis, Filarial.
- chemical , therapeutic use : Diethylcarbamazine, Ivermectin.
- Adult, Animals, Double-Blind Method, Drug Evaluation, Follow-Up Studies, Humans, Middle Aged, Polynesia.
Abstract
In October 1989, 58 apparently healthy Polynesian Wuchereria bancrofti carriers, in whom microfilarial (mf) density was greater than or equal to 100 mf/ml, were randomly allocated to treatment groups receiving single doses of either ivermectin at 100 mcg/kg or diethylcarbamazine (DEC) at 3 and 6 mg/kg. Six months later, half of the carriers initially treated with ivermectin 100 mcg/kg or DEC 3 mg/kg were given a second similar dose while the rest were given a placebo. Six months later again, all of the carriers received a last treatment dose similar to the initial one. The results observed during the 12-month period which followed this last treatment have confirmed that (i) in terms of immediate clearance or complete negativation of microfilaremia, the efficacy of ivermectin is higher than that of DEC (at dosage of 3 or 6 mg/kg), (ii) DEC is more effective than ivermectin in sustaining the reduction of microfilaremia over a longer period of time and (iii) the efficacy of repeated single doses of either DEC 3 mg/kg or ivermectin 100 mcg/kg is much higher when given semi-annually than annually.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed: 1519031
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pubmed:1519031Le document en format XML
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Six months later, half of the carriers initially treated with ivermectin 100 mcg/kg or DEC 3 mg/kg were given a second similar dose while the rest were given a placebo. Six months later again, all of the carriers received a last treatment dose similar to the initial one. The results observed during the 12-month period which followed this last treatment have confirmed that (i) in terms of immediate clearance or complete negativation of microfilaremia, the efficacy of ivermectin is higher than that of DEC (at dosage of 3 or 6 mg/kg), (ii) DEC is more effective than ivermectin in sustaining the reduction of microfilaremia over a longer period of time and (iii) the efficacy of repeated single doses of either DEC 3 mg/kg or ivermectin 100 mcg/kg is much higher when given semi-annually than annually.(ABSTRACT TRUNCATED AT 250 WORDS)</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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