Regulation of jird lymphocyte responsiveness to fractionated antigens of Brugia pahangi.
Identifieur interne : 005930 ( PubMed/Checkpoint ); précédent : 005929; suivant : 005931Regulation of jird lymphocyte responsiveness to fractionated antigens of Brugia pahangi.
Auteurs : L A Michaud ; P J LammieSource :
- Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) [ 0177-2392 ] ; 1988.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Animaux, Antigènes d'helminthe (analyse), Antigènes d'helminthe (immunologie), Brugia (immunologie), Chromatographie en phase liquide à haute performance, Chromatographie sur gel, Filariose lymphatique (immunologie), Filarioses (immunologie), Fractionnement chimique, Gerbillinae, Mâle, Noeuds lymphatiques (immunologie), Rate (immunologie), Électrophorèse sur gel de polyacrylamide, Épitopes (analyse), Épitopes (immunologie).
- MESH :
- analyse : Antigènes d'helminthe, Épitopes.
- immunologie : Antigènes d'helminthe, Brugia, Filariose lymphatique, Filarioses, Noeuds lymphatiques, Rate, Épitopes.
- Activation des lymphocytes, Animaux, Chromatographie en phase liquide à haute performance, Chromatographie sur gel, Fractionnement chimique, Gerbillinae, Mâle, Électrophorèse sur gel de polyacrylamide.
English descriptors
- KwdEn :
- Animals, Antigens, Helminth (analysis), Antigens, Helminth (immunology), Brugia (immunology), Chemical Fractionation, Chromatography, Gel, Chromatography, High Pressure Liquid, Electrophoresis, Polyacrylamide Gel, Elephantiasis, Filarial (immunology), Epitopes (analysis), Epitopes (immunology), Filariasis (immunology), Gerbillinae, Lymph Nodes (immunology), Lymphocyte Activation, Male, Spleen (immunology).
- MESH :
- chemical , analysis : Antigens, Helminth, Epitopes.
- chemical , immunology : Antigens, Helminth, Epitopes.
- immunology : Brugia, Elephantiasis, Filarial, Filariasis, Lymph Nodes, Spleen.
- Animals, Chemical Fractionation, Chromatography, Gel, Chromatography, High Pressure Liquid, Electrophoresis, Polyacrylamide Gel, Gerbillinae, Lymphocyte Activation, Male.
Abstract
The present studies were designed to characterize the in vitro responsiveness of jird lymphocyte populations to fractionated Brugia pahangi antigens in the B. pahangi-jird model of filariasis. Proliferative responses to spleen and lymph node cells from normal, B. pahangi-immunized, and infected jirds to HPLC fractions of soluble and detergent extracted antigens were assayed. High molecular weight fractions of soluble B. pahangi were weakly mitogenic for normal lymph node, but not normal spleen cell populations. Lymphocytes from B. pahangi-immunized jirds responded to a wide range of fractions corresponding to antigens with molecular weights from less than 10 kd to greater than 300 kd. A shift in the reactivity of spleen cells from infected jirds to fractions of both soluble and detergent extracts was observed over the course of B. pahangi infection. Spleen cells from microfilaremic jirds consistently failed to respond to any of the fractions which significantly stimulated spleen cells from animals with prepatent infections. In contrast, lymph node cells from prepatent and microfilaremic jirds displayed similar profiles of antigenic reactivity. These results suggest that the development of patent infection leads to a complete down regulation of splenic, but not lymph node cellular reactivity to parasite antigen.
PubMed: 2465563
Affiliations:
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parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)</title><idno type="ISSN">0177-2392</idno><imprint><date when="1988" type="published">1988</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Helminth (analysis)</term><term>Antigens, Helminth (immunology)</term><term>Brugia (immunology)</term><term>Chemical Fractionation</term><term>Chromatography, Gel</term><term>Chromatography, High Pressure Liquid</term><term>Electrophoresis, Polyacrylamide Gel</term><term>Elephantiasis, Filarial (immunology)</term><term>Epitopes (analysis)</term><term>Epitopes (immunology)</term><term>Filariasis (immunology)</term><term>Gerbillinae</term><term>Lymph Nodes (immunology)</term><term>Lymphocyte Activation</term><term>Male</term><term>Spleen (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term><term>Animaux</term><term>Antigènes d'helminthe (analyse)</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia (immunologie)</term><term>Chromatographie en phase liquide à haute performance</term><term>Chromatographie sur gel</term><term>Filariose lymphatique (immunologie)</term><term>Filarioses (immunologie)</term><term>Fractionnement chimique</term><term>Gerbillinae</term><term>Mâle</term><term>Noeuds lymphatiques (immunologie)</term><term>Rate (immunologie)</term><term>Électrophorèse sur gel de polyacrylamide</term><term>Épitopes (analyse)</term><term>Épitopes (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, Helminth</term><term>Epitopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term><term>Epitopes</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Brugia</term><term>Filariose lymphatique</term><term>Filarioses</term><term>Noeuds lymphatiques</term><term>Rate</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Lymph Nodes</term><term>Spleen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chemical Fractionation</term><term>Chromatography, Gel</term><term>Chromatography, High Pressure Liquid</term><term>Electrophoresis, Polyacrylamide Gel</term><term>Gerbillinae</term><term>Lymphocyte Activation</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Animaux</term><term>Chromatographie en phase liquide à haute performance</term><term>Chromatographie sur gel</term><term>Fractionnement chimique</term><term>Gerbillinae</term><term>Mâle</term><term>Électrophorèse sur gel de polyacrylamide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present studies were designed to characterize the in vitro responsiveness of jird lymphocyte populations to fractionated Brugia pahangi antigens in the B. pahangi-jird model of filariasis. Proliferative responses to spleen and lymph node cells from normal, B. pahangi-immunized, and infected jirds to HPLC fractions of soluble and detergent extracted antigens were assayed. High molecular weight fractions of soluble B. pahangi were weakly mitogenic for normal lymph node, but not normal spleen cell populations. Lymphocytes from B. pahangi-immunized jirds responded to a wide range of fractions corresponding to antigens with molecular weights from less than 10 kd to greater than 300 kd. A shift in the reactivity of spleen cells from infected jirds to fractions of both soluble and detergent extracts was observed over the course of B. pahangi infection. Spleen cells from microfilaremic jirds consistently failed to respond to any of the fractions which significantly stimulated spleen cells from animals with prepatent infections. In contrast, lymph node cells from prepatent and microfilaremic jirds displayed similar profiles of antigenic reactivity. These results suggest that the development of patent infection leads to a complete down regulation of splenic, but not lymph node cellular reactivity to parasite antigen.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2465563</PMID><DateCreated><Year>1989</Year><Month>04</Month><Day>04</Day></DateCreated><DateCompleted><Year>1989</Year><Month>04</Month><Day>04</Day></DateCompleted><DateRevised><Year>2015</Year><Month>08</Month><Day>11</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0177-2392</ISSN><JournalIssue CitedMedium="Print"><Volume>39</Volume><Issue>4</Issue><PubDate><Year>1988</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)</Title><ISOAbbreviation>Trop. Med. Parasitol.</ISOAbbreviation></Journal><ArticleTitle>Regulation of jird lymphocyte responsiveness to fractionated antigens of Brugia pahangi.</ArticleTitle><Pagination><MedlinePgn>317-21</MedlinePgn></Pagination><Abstract><AbstractText>The present studies were designed to characterize the in vitro responsiveness of jird lymphocyte populations to fractionated Brugia pahangi antigens in the B. pahangi-jird model of filariasis. Proliferative responses to spleen and lymph node cells from normal, B. pahangi-immunized, and infected jirds to HPLC fractions of soluble and detergent extracted antigens were assayed. High molecular weight fractions of soluble B. pahangi were weakly mitogenic for normal lymph node, but not normal spleen cell populations. Lymphocytes from B. pahangi-immunized jirds responded to a wide range of fractions corresponding to antigens with molecular weights from less than 10 kd to greater than 300 kd. A shift in the reactivity of spleen cells from infected jirds to fractions of both soluble and detergent extracts was observed over the course of B. pahangi infection. Spleen cells from microfilaremic jirds consistently failed to respond to any of the fractions which significantly stimulated spleen cells from animals with prepatent infections. In contrast, lymph node cells from prepatent and microfilaremic jirds displayed similar profiles of antigenic reactivity. These results suggest that the development of patent infection leads to a complete down regulation of splenic, but not lymph node cellular reactivity to parasite antigen.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Michaud</LastName><ForeName>L A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Immunology and Parasitology, Louisiana State University Medical Center, New Orleans.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lammie</LastName><ForeName>P J</ForeName><Initials>PJ</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>AI-24459</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Trop Med Parasitol</MedlineTA><NlmUniqueID>8503728</NlmUniqueID><ISSNLinking>0177-2392</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000939">Epitopes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000947" MajorTopicYN="N">Antigens, Helminth</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002009" MajorTopicYN="N">Brugia</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005591" MajorTopicYN="N">Chemical Fractionation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002850" MajorTopicYN="N">Chromatography, Gel</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004591" MajorTopicYN="N">Electrophoresis, Polyacrylamide Gel</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000939" MajorTopicYN="N">Epitopes</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005368" MajorTopicYN="N">Filariasis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005849" MajorTopicYN="N">Gerbillinae</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008213" MajorTopicYN="Y">Lymphocyte Activation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013154" MajorTopicYN="N">Spleen</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1988</Year><Month>12</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1988</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1988</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2465563</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Lammie, P J" sort="Lammie, P J" uniqKey="Lammie P" first="P J" last="Lammie">P J Lammie</name><name sortKey="Michaud, L A" sort="Michaud, L A" uniqKey="Michaud L" first="L A" last="Michaud">L A Michaud</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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