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A study of the CD4: CD8 ratio in peripheral T lymphocytes of rural Papua New Guineans: a reduced ratio assessed with regard to infectious agents.

Identifieur interne : 00D727 ( Main/Merge ); précédent : 00D726; suivant : 00D728

A study of the CD4: CD8 ratio in peripheral T lymphocytes of rural Papua New Guineans: a reduced ratio assessed with regard to infectious agents.

Auteurs : P F Turner [Australie]

Source :

RBID : pubmed:8059546

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English descriptors

Abstract

The CD4:CD8 ratio in peripheral T lymphocytes was determined in 123 Papua New Guineans aged over 5 years from Rumginae, a rural area of the Western Province. 18 people had a ratio less than 1.0. No antibody response to human immunodeficiency virus 1 (HIV 1) was found within the group. Hepatitis B surface antigen was more commonly associated with a CD4:CD8 ratio less than 1.0 than were microfilaraemia or a positive Mantoux test. Hepatitis B infection may be one of the causes of the CD4:CD8 ratio reduction within the community. Irrespective of the cause, other studies in Papua New Guinea have shown that a CD4:CD8 ratio less than 1.0 may result more from an increase in the CD8 cell count than a reduction in the CD4 cell count.

PubMed: 8059546

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pubmed:8059546

Le document en format XML

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<nlm:affiliation>Anton Breinl Centre for Tropical Health and Medicine, James Cook University of North Queensland, Townsville, Australia.</nlm:affiliation>
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<term>Age Distribution</term>
<term>Aged</term>
<term>Animals</term>
<term>CD4-CD8 Ratio</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Elephantiasis, Filarial (blood)</term>
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<term>Elephantiasis, Filarial (immunology)</term>
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<term>Hepatitis B (epidemiology)</term>
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<term>Hepatitis B Surface Antigens (blood)</term>
<term>Humans</term>
<term>Male</term>
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<term>Adolescent</term>
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<term>Antigènes de surface du virus de l'hépatite B (sang)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
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<term>Tuberculose</term>
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<term>Adolescent</term>
<term>Adult</term>
<term>Age Distribution</term>
<term>Aged</term>
<term>Animals</term>
<term>CD4-CD8 Ratio</term>
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<term>Child, Preschool</term>
<term>Female</term>
<term>HIV-1</term>
<term>Humans</term>
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<term>Population Surveillance</term>
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<term>Seroepidemiologic Studies</term>
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<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
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<term>Humains</term>
<term>Mâle</term>
<term>Population rurale</term>
<term>Prévalence</term>
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<term>Répartition par âge</term>
<term>Sujet âgé</term>
<term>Surveillance de la population</term>
<term>Test tuberculinique</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
<term>Wuchereria bancrofti</term>
<term>Études séroépidémiologiques</term>
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<div type="abstract" xml:lang="en">The CD4:CD8 ratio in peripheral T lymphocytes was determined in 123 Papua New Guineans aged over 5 years from Rumginae, a rural area of the Western Province. 18 people had a ratio less than 1.0. No antibody response to human immunodeficiency virus 1 (HIV 1) was found within the group. Hepatitis B surface antigen was more commonly associated with a CD4:CD8 ratio less than 1.0 than were microfilaraemia or a positive Mantoux test. Hepatitis B infection may be one of the causes of the CD4:CD8 ratio reduction within the community. Irrespective of the cause, other studies in Papua New Guinea have shown that a CD4:CD8 ratio less than 1.0 may result more from an increase in the CD8 cell count than a reduction in the CD4 cell count.</div>
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