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A study of the CD4: CD8 ratio in peripheral T lymphocytes of rural Papua New Guineans: a reduced ratio assessed with regard to infectious agents.

Identifieur interne : 005692 ( PubMed/Corpus ); précédent : 005691; suivant : 005693

A study of the CD4: CD8 ratio in peripheral T lymphocytes of rural Papua New Guineans: a reduced ratio assessed with regard to infectious agents.

Auteurs : P F Turner

Source :

RBID : pubmed:8059546

English descriptors

Abstract

The CD4:CD8 ratio in peripheral T lymphocytes was determined in 123 Papua New Guineans aged over 5 years from Rumginae, a rural area of the Western Province. 18 people had a ratio less than 1.0. No antibody response to human immunodeficiency virus 1 (HIV 1) was found within the group. Hepatitis B surface antigen was more commonly associated with a CD4:CD8 ratio less than 1.0 than were microfilaraemia or a positive Mantoux test. Hepatitis B infection may be one of the causes of the CD4:CD8 ratio reduction within the community. Irrespective of the cause, other studies in Papua New Guinea have shown that a CD4:CD8 ratio less than 1.0 may result more from an increase in the CD8 cell count than a reduction in the CD4 cell count.

PubMed: 8059546

Links to Exploration step

pubmed:8059546

Le document en format XML

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<title xml:lang="en">A study of the CD4: CD8 ratio in peripheral T lymphocytes of rural Papua New Guineans: a reduced ratio assessed with regard to infectious agents.</title>
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<term>CD4-CD8 Ratio</term>
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<term>Elephantiasis, Filarial (blood)</term>
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<div type="abstract" xml:lang="en">The CD4:CD8 ratio in peripheral T lymphocytes was determined in 123 Papua New Guineans aged over 5 years from Rumginae, a rural area of the Western Province. 18 people had a ratio less than 1.0. No antibody response to human immunodeficiency virus 1 (HIV 1) was found within the group. Hepatitis B surface antigen was more commonly associated with a CD4:CD8 ratio less than 1.0 than were microfilaraemia or a positive Mantoux test. Hepatitis B infection may be one of the causes of the CD4:CD8 ratio reduction within the community. Irrespective of the cause, other studies in Papua New Guinea have shown that a CD4:CD8 ratio less than 1.0 may result more from an increase in the CD8 cell count than a reduction in the CD4 cell count.</div>
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