Risk of decline in upper-body function and symptoms among older breast cancer patients
Identifieur interne : 007F67 ( Main/Merge ); précédent : 007F66; suivant : 007F68Risk of decline in upper-body function and symptoms among older breast cancer patients
Auteurs : Jennifer L. Westrup [États-Unis] ; Timothy L. Lash [États-Unis] ; Soe Soe Thwin [États-Unis] ; Rebecca A. Silliman [États-Unis]Source :
- Journal of general internal medicine [ 0884-8734 ] ; 2006.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Personne âgée, Médecine.
English descriptors
- KwdEn :
Abstract
BACKGROUND: Decline In upper-body function and development of upper-body symptoms are adverse effects of breast cancer therapy and may affect functional independence, particularly among older survivors. The long-term risks and predictors are poorly understood. OBJECTIVE: To characterize the risk of decline in upper-body function and development of symptoms over 4 years of follow-up. DESIGN; We used a prospective cohort design. PARTICIPANTS: Six hundred and forty-four early stage breast cancer patients 65 years old or older at surgery enrolled In Rhode Island, North Carolina, Minnesota, and Los Angeles between 1996 and 1999. MEASUREMENTS: Upper-body function and symptoms were self-reported at baseline, 6, 15 months, and annually thereafter to 51 months' after surgery. RESULTS: One half of the participants had a decline in upper-body function and one-quarter developed upper-body symptoms. Breast cancer patients were 5-fold more likely to have a decline in upper-body function over 4 years of follow-up than a similar cohort without breast cancer. Better baseline mental health protected against a decline in upper-body function (odds ratio [OR]=0.93, 95% confidence interval [CI] 0.88 to 0.97 for 8-point higher mental health index). Baseline obesity (OR for body mass index [BMI] ≥ 30 kg/m2 vs <30 kg/m2=2.5, CI=1.6 to 4.0) and axillary node dissection (OR for axillary dissection vs not =3.9, CI=1.1 to 14) predicted the development of upper-body symptoms. CONCLUSIONS: Primary care physicians should address upper-body function and symptoms with older breast cancer patients, and Inform them that these complications of breast cancer treatment are common.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000520
- to stream PascalFrancis, to step Curation: 000440
- to stream PascalFrancis, to step Checkpoint: 000507
Links to Exploration step
Pascal:06-0373679Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Risk of decline in upper-body function and symptoms among older breast cancer patients</title><author><name sortKey="Westrup, Jennifer L" sort="Westrup, Jennifer L" uniqKey="Westrup J" first="Jennifer L." last="Westrup">Jennifer L. Westrup</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Hematology and Medical Oncology Section, Department of Medicine, Boston University School of Medicine</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lash, Timothy L" sort="Lash, Timothy L" uniqKey="Lash T" first="Timothy L." last="Lash">Timothy L. Lash</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Geriatrics Section, Department of Medicine, Boston University School of Medicine</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Epidemiology, Boston University School of Public Health</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Thwin, Soe Soe" sort="Thwin, Soe Soe" uniqKey="Thwin S" first="Soe Soe" last="Thwin">Soe Soe Thwin</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Geriatrics Section, Department of Medicine, Boston University School of Medicine</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Silliman, Rebecca A" sort="Silliman, Rebecca A" uniqKey="Silliman R" first="Rebecca A." last="Silliman">Rebecca A. Silliman</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Geriatrics Section, Department of Medicine, Boston University School of Medicine</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Epidemiology, Boston University School of Public Health</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0373679</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0373679 INIST</idno><idno type="RBID">Pascal:06-0373679</idno><idno type="wicri:Area/PascalFrancis/Corpus">000520</idno><idno type="wicri:Area/PascalFrancis/Curation">000440</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000507</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000507</idno><idno type="wicri:doubleKey">0884-8734:2006:Westrup J:risk:of:decline</idno><idno type="wicri:Area/Main/Merge">007F67</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Risk of decline in upper-body function and symptoms among older breast cancer patients</title><author><name sortKey="Westrup, Jennifer L" sort="Westrup, Jennifer L" uniqKey="Westrup J" first="Jennifer L." last="Westrup">Jennifer L. Westrup</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Hematology and Medical Oncology Section, Department of Medicine, Boston University School of Medicine</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lash, Timothy L" sort="Lash, Timothy L" uniqKey="Lash T" first="Timothy L." last="Lash">Timothy L. Lash</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Geriatrics Section, Department of Medicine, Boston University School of Medicine</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Epidemiology, Boston University School of Public Health</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Thwin, Soe Soe" sort="Thwin, Soe Soe" uniqKey="Thwin S" first="Soe Soe" last="Thwin">Soe Soe Thwin</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Geriatrics Section, Department of Medicine, Boston University School of Medicine</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Silliman, Rebecca A" sort="Silliman, Rebecca A" uniqKey="Silliman R" first="Rebecca A." last="Silliman">Rebecca A. Silliman</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Geriatrics Section, Department of Medicine, Boston University School of Medicine</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Epidemiology, Boston University School of Public Health</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of general internal medicine</title><title level="j" type="abbreviated">J. gen. intern. med.</title><idno type="ISSN">0884-8734</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of general internal medicine</title><title level="j" type="abbreviated">J. gen. intern. med.</title><idno type="ISSN">0884-8734</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age</term><term>Breast cancer</term><term>Breast tumor</term><term>Complication</term><term>Elderly</term><term>Epidemiology</term><term>Lymphedema</term><term>Malignant tumor</term><term>Mammary gland</term><term>Medicine</term><term>Patient</term><term>Risk factor</term><term>Symptomatology</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Tumeur maligne</term><term>Facteur risque</term><term>Lymphoedème</term><term>Epidémiologie</term><term>Symptomatologie</term><term>Personne âgée</term><term>Age</term><term>Glande mammaire</term><term>Malade</term><term>Complication</term><term>Traitement</term><term>Médecine</term><term>Cancer sein</term><term>Tumeur sein</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Personne âgée</term><term>Médecine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND: Decline In upper-body function and development of upper-body symptoms are adverse effects of breast cancer therapy and may affect functional independence, particularly among older survivors. The long-term risks and predictors are poorly understood. OBJECTIVE: To characterize the risk of decline in upper-body function and development of symptoms over 4 years of follow-up. DESIGN; We used a prospective cohort design. PARTICIPANTS: Six hundred and forty-four early stage breast cancer patients 65 years old or older at surgery enrolled In Rhode Island, North Carolina, Minnesota, and Los Angeles between 1996 and 1999. MEASUREMENTS: Upper-body function and symptoms were self-reported at baseline, 6, 15 months, and annually thereafter to 51 months' after surgery. RESULTS: One half of the participants had a decline in upper-body function and one-quarter developed upper-body symptoms. Breast cancer patients were 5-fold more likely to have a decline in upper-body function over 4 years of follow-up than a similar cohort without breast cancer. Better baseline mental health protected against a decline in upper-body function (odds ratio [OR]=0.93, 95% confidence interval [CI] 0.88 to 0.97 for 8-point higher mental health index). Baseline obesity (OR for body mass index [BMI] ≥ 30 kg/m<sup>2</sup> vs <30 kg/m<sup>2</sup>=2.5, CI=1.6 to 4.0) and axillary node dissection (OR for axillary dissection vs not =3.9, CI=1.1 to 14) predicted the development of upper-body symptoms. CONCLUSIONS: Primary care physicians should address upper-body function and symptoms with older breast cancer patients, and Inform them that these complications of breast cancer treatment are common.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Westrup, Jennifer L" sort="Westrup, Jennifer L" uniqKey="Westrup J" first="Jennifer L." last="Westrup">Jennifer L. Westrup</name></region><name sortKey="Lash, Timothy L" sort="Lash, Timothy L" uniqKey="Lash T" first="Timothy L." last="Lash">Timothy L. Lash</name><name sortKey="Lash, Timothy L" sort="Lash, Timothy L" uniqKey="Lash T" first="Timothy L." last="Lash">Timothy L. Lash</name><name sortKey="Silliman, Rebecca A" sort="Silliman, Rebecca A" uniqKey="Silliman R" first="Rebecca A." last="Silliman">Rebecca A. Silliman</name><name sortKey="Silliman, Rebecca A" sort="Silliman, Rebecca A" uniqKey="Silliman R" first="Rebecca A." last="Silliman">Rebecca A. Silliman</name><name sortKey="Thwin, Soe Soe" sort="Thwin, Soe Soe" uniqKey="Thwin S" first="Soe Soe" last="Thwin">Soe Soe Thwin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007F67 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 007F67 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Merge
|type= RBID
|clé= Pascal:06-0373679
|texte= Risk of decline in upper-body function and symptoms among older breast cancer patients
}}
| This area was generated with Dilib version V0.6.31. |  |