Effects of Adipose-derived Stromal Cells and of their Extract on Wound Healing in a Mouse Model
Identifieur interne : 005984 ( Main/Merge ); précédent : 005983; suivant : 005985Effects of Adipose-derived Stromal Cells and of their Extract on Wound Healing in a Mouse Model
Auteurs : Jin Soo Lim [Corée du Sud] ; Gyeol Yoo [Corée du Sud]Source :
- Journal of Korean Medical Science [ 1011-8934 ] ; 2010.
Abstract
In this study, the authors investigated the effects of adipose-derived stromal cells (ADSCs) and of their extract on wound healing. After creating wound healing splint model on the backs of mice, ADSCs and their extract were applied. Wound healing rates were calculated at 3, 5, 7, 10, and 14 days after the wounding, and tissues were harvested at 7 and 14 days for histological analysis. Wound healing rates were significantly higher at 7, 10, and 14 days in the cell group than in the control, but in the cell extract group wound healing rates were significantly decreased (
Url:
DOI: 10.3346/jkms.2010.25.5.746
PubMed: 20436712
PubMed Central: 2858835
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of Adipose-derived Stromal Cells and of their Extract on Wound Healing in a Mouse Model</title><author><name sortKey="Lim, Jin Soo" sort="Lim, Jin Soo" uniqKey="Lim J" first="Jin Soo" last="Lim">Jin Soo Lim</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Plastic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Plastic Surgery, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yoo, Gyeol" sort="Yoo, Gyeol" uniqKey="Yoo G" first="Gyeol" last="Yoo">Gyeol Yoo</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Plastic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Plastic Surgery, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20436712</idno><idno type="pmc">2858835</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858835</idno><idno type="RBID">PMC:2858835</idno><idno type="doi">10.3346/jkms.2010.25.5.746</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">004088</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004088</idno><idno type="wicri:Area/Pmc/Curation">004087</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004087</idno><idno type="wicri:Area/Pmc/Checkpoint">003442</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003442</idno><idno type="wicri:Area/Ncbi/Merge">003A85</idno><idno type="wicri:Area/Ncbi/Curation">003A85</idno><idno type="wicri:Area/Ncbi/Checkpoint">003A85</idno><idno type="wicri:doubleKey">1011-8934:2010:Lim J:effects:of:adipose</idno><idno type="wicri:Area/Main/Merge">005984</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of Adipose-derived Stromal Cells and of their Extract on Wound Healing in a Mouse Model</title><author><name sortKey="Lim, Jin Soo" sort="Lim, Jin Soo" uniqKey="Lim J" first="Jin Soo" last="Lim">Jin Soo Lim</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Plastic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Plastic Surgery, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yoo, Gyeol" sort="Yoo, Gyeol" uniqKey="Yoo G" first="Gyeol" last="Yoo">Gyeol Yoo</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Plastic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Plastic Surgery, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Korean Medical Science</title><idno type="ISSN">1011-8934</idno><idno type="eISSN">1598-6357</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In this study, the authors investigated the effects of adipose-derived stromal cells (ADSCs) and of their extract on wound healing. After creating wound healing splint model on the backs of mice, ADSCs and their extract were applied. Wound healing rates were calculated at 3, 5, 7, 10, and 14 days after the wounding, and tissues were harvested at 7 and 14 days for histological analysis. Wound healing rates were significantly higher at 7, 10, and 14 days in the cell group than in the control, but in the cell extract group wound healing rates were significantly decreased (<italic>P</italic><0.05). Histological scores and capillary densities in the cell group were significantly higher at 2 weeks (<italic>P</italic><0.05). In the cell group, thick inflammatory cell infiltration and many capillaries were observed at 1 week, and thick epithelium and numerous large capillaries were observed at 2 weeks. The present study suggests that ADSCs accelerate wound healing as known, and the effects of ADSCs on wound healing may be due to replacing insufficient cells by differentiation of ADSCs in the wound and secreting growth factors by differentiated cells, and not due to the effect of factors within ADSCs.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Martin, P" uniqKey="Martin P">P Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falanga, V" uniqKey="Falanga V">V Falanga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zuk, Pa" uniqKey="Zuk P">PA Zuk</name></author><author><name sortKey="Zhu, M" uniqKey="Zhu M">M Zhu</name></author><author><name sortKey="Ashjian, P" uniqKey="Ashjian P">P Ashjian</name></author><author><name sortKey="De Ugarte, Da" uniqKey="De Ugarte D">DA De Ugarte</name></author><author><name sortKey="Huang, Ji" uniqKey="Huang J">JI 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