Histopathological analysis of vesicular and bullous lesions in Kaposi sarcoma
Identifieur interne : 004277 ( Main/Merge ); précédent : 004276; suivant : 004278Histopathological analysis of vesicular and bullous lesions in Kaposi sarcoma
Auteurs : Nilüfer Onak Kandemir [Turquie] ; Figen Barut [Turquie] ; Banu Do An Gün [Turquie] ; Nilgün Solak Tekin [Turquie] ; Sevinç Hallaç Keser [Turquie] ; Krü O Uz Özdamar [Turquie]Source :
- Diagnostic Pathology [ 1746-1596 ] ; 2012.
Abstract
In this study, the clinical and morphological features of vesiculobullous lesions observed in Kaposi sarcoma are analyzed, and the features of bullous Kaposi sarcoma cases are emphasized.
A total of 178 biopsy materials of 75 cases diagnosed as classic-type cutaneous Kaposi sarcoma were reviewed. Twenty-five cases showing vesiculobullous features were included in the study. Tumor, epidermis, dermis, and clinical data regarding these cases was evaluated.
Vesicular changes were observed in 21 (12%) out of 178 lesions of the 75 cases, while bullous changes were present in only 4 (2%). In all cases where vesicular and bullous changes were detected, tumor, epidermis, and dermis changes were similar. All cases were nodular stage KS lesions, whereas hyperkeratosis and serum exudation in the epidermis, marked edema in the dermis, and enlarged lymphatic vessels and chronic inflammatory response were observed.
Our findings suggest that changes in vascular resistance occurring during tumor progression are the most important factors comprising vesiculobullous morphology.
The virtual slide(s) for this article can be found here:
Url:
DOI: 10.1186/1746-1596-7-101
PubMed: 22894735
PubMed Central: 3488507
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last="Barut">Figen Barut</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pathology, Karaelmas University, Faculty of Medicine, Zonguldak, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pathology, Karaelmas University, Faculty of Medicine, Zonguldak</wicri:regionArea><wicri:noRegion>Zonguldak</wicri:noRegion></affiliation></author><author><name sortKey="Gun, Banu Do An" sort="Gun, Banu Do An" uniqKey="Gun B" first="Banu Do An" last="Gün">Banu Do An Gün</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pathology, Karaelmas University, Faculty of Medicine, Zonguldak, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pathology, Karaelmas University, Faculty of Medicine, Zonguldak</wicri:regionArea><wicri:noRegion>Zonguldak</wicri:noRegion></affiliation></author><author><name sortKey="Tekin, Nilgun Solak" sort="Tekin, Nilgun Solak" uniqKey="Tekin N" first="Nilgün Solak" last="Tekin">Nilgün Solak Tekin</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Dermathology, Karaelmas University, Faculty of Medicine, Zonguldak, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Dermathology, Karaelmas University, Faculty of Medicine, Zonguldak</wicri:regionArea><wicri:noRegion>Zonguldak</wicri:noRegion></affiliation></author><author><name sortKey="Keser, Sevinc Hallac" sort="Keser, Sevinc Hallac" uniqKey="Keser S" first="Sevinç Hallaç" last="Keser">Sevinç Hallaç Keser</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Pathology, Lütfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pathology, Lütfi Kirdar Kartal Training and Research Hospital, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Ozdamar, Kru O Uz" sort="Ozdamar, Kru O Uz" uniqKey="Ozdamar " first=" Krü O Uz" last="Özdamar"> Krü O Uz Özdamar</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pathology, Karaelmas University, Faculty of Medicine, Zonguldak, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pathology, Karaelmas University, Faculty of Medicine, Zonguldak</wicri:regionArea><wicri:noRegion>Zonguldak</wicri:noRegion></affiliation></author></analytic><series><title level="j">Diagnostic Pathology</title><idno type="eISSN">1746-1596</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>In this study, the clinical and morphological features of vesiculobullous lesions observed in Kaposi sarcoma are analyzed, and the features of bullous Kaposi sarcoma cases are emphasized.</p></sec><sec><title>Methods</title><p>A total of 178 biopsy materials of 75 cases diagnosed as classic-type cutaneous Kaposi sarcoma were reviewed. Twenty-five cases showing vesiculobullous features were included in the study. Tumor, epidermis, dermis, and clinical data regarding these cases was evaluated.</p></sec><sec><title>Results</title><p>Vesicular changes were observed in 21 (12%) out of 178 lesions of the 75 cases, while bullous changes were present in only 4 (2%). In all cases where vesicular and bullous changes were detected, tumor, epidermis, and dermis changes were similar. All cases were nodular stage KS lesions, whereas hyperkeratosis and serum exudation in the epidermis, marked edema in the dermis, and enlarged lymphatic vessels and chronic inflammatory response were observed.</p></sec><sec><title>Conclusions</title><p>Our findings suggest that changes in vascular resistance occurring during tumor progression are the most important factors comprising vesiculobullous morphology.</p></sec><sec><title>Virtual slides</title><p>The virtual slide(s) for this article can be found here:
<ext-link ext-link-type="uri" xlink:href="http://www.diagnosticpathology.diagnomx.eu/vs/1646397188748474">http://www.diagnosticpathology.diagnomx.eu/vs/1646397188748474</ext-link></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Weiss, Sw" uniqKey="Weiss S">SW Weiss</name></author><author><name sortKey="Goldblum, Jr" uniqKey="Goldblum J">JR Goldblum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwartz, Ra" uniqKey="Schwartz R">RA Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwartz, Ra" uniqKey="Schwartz R">RA Schwartz</name></author><author><name sortKey="Micali, G" uniqKey="Micali G">G Micali</name></author><author><name sortKey="Nasca, Mr" uniqKey="Nasca M">MR Nasca</name></author><author><name sortKey="Scuderi, L" uniqKey="Scuderi L">L Scuderi</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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sortKey="Dethier, F" uniqKey="Dethier F">F deThier</name></author><author><name sortKey="Dedobbeleer, G" uniqKey="Dedobbeleer G">G deDobbeleer</name></author><author><name sortKey="Heenen, M" uniqKey="Heenen M">M Heenen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gange, Rw" uniqKey="Gange R">RW Gange</name></author><author><name sortKey="Wilson Jones, E" uniqKey="Wilson Jones E">E Wilson Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name></author><author><name sortKey="Schapiro, B" uniqKey="Schapiro B">B Schapiro</name></author><author><name sortKey="Harrist, Tj" uniqKey="Harrist T">TJ Harrist</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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