Association of CTLA4 gene polymorphisms with lymphatic filariasis in an East Malaysian population.
Identifieur interne : 005073 ( Main/Exploration ); précédent : 005072; suivant : 005074Association of CTLA4 gene polymorphisms with lymphatic filariasis in an East Malaysian population.
Auteurs : Zulkarnain Md Idris [Malaisie] ; Noorizan Miswan ; Jamail Muhi ; Tajul Ariffin Awang Mohd ; Jürgen F J. Kun ; Rahmah NoordinSource :
- Human immunology [ 1879-1166 ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Allèles, Antigène CTLA-4, Antigènes CD (génétique), Enfant, Enfant d'âge préscolaire, Exons, Femelle, Filariose lymphatique (génétique), Fréquence d'allèle, Génotype, Humains, Jeune adulte, Malaisie, Mâle, Polymorphisme de nucléotide simple (génétique), Population d'origine asiatique (génétique), Prédisposition génétique à une maladie, Régions promotrices (génétique) (génétique), Sujet âgé, Études cas-témoins.
- MESH :
- génétique : Antigènes CD, Filariose lymphatique, Polymorphisme de nucléotide simple, Population d'origine asiatique, Régions promotrices (génétique).
- Adolescent, Adulte, Adulte d'âge moyen, Allèles, Antigène CTLA-4, Enfant, Enfant d'âge préscolaire, Exons, Femelle, Fréquence d'allèle, Génotype, Humains, Jeune adulte, Malaisie, Mâle, Prédisposition génétique à une maladie, Sujet âgé, Études cas-témoins.
- Wicri :
- geographic : Malaisie.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Alleles, Antigens, CD (genetics), Asian Continental Ancestry Group (genetics), CTLA-4 Antigen, Case-Control Studies, Child, Child, Preschool, Elephantiasis, Filarial (genetics), Exons, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Malaysia, Male, Middle Aged, Polymorphism, Single Nucleotide (genetics), Promoter Regions, Genetic (genetics), Young Adult.
- MESH :
- chemical , genetics : Antigens, CD.
- geographic : Malaysia.
- genetics : Asian Continental Ancestry Group, Elephantiasis, Filarial, Polymorphism, Single Nucleotide, Promoter Regions, Genetic.
- Adolescent, Adult, Aged, Alleles, CTLA-4 Antigen, Case-Control Studies, Child, Child, Preschool, Exons, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Young Adult.
Abstract
Lymphatic filariasis (LF) is a parasitic disease caused by threadlike worms of the Brugia and Wuchereria species that live in the human lymphatic system. Regulatory T cells (Tregs) may play a key role in the pathogenesis of LF, and cytotoxic T-lymphocyte antigen-4 (CTLA4) expressed by Tregs is a potential candidate gene because it modulates T-cell activation. A case-control study was performed to establish a potential association of 5 CTLA4 gene promoter single nucleotide polymorphisms (SNPs; rs733618, rs11571316, rs5742909, rs231775, and rs16840252) with the occurrence of LF in an East Malaysian population (320 LF-infected individuals and 150 healthy controls). Polymorphisms were evaluated using TaqMan real-time polymerase chain reaction followed by direct sequencing. LF carriers of the rs733618 AG genotypes (p = 0.02) and those with combined minor allele G carriers (AG + GG; p = 0.01) exhibited a significantly decreased risk for LF. Among the asymptomatic amicrofilaremic cases, positive associations were reported for all genotypes and variants of rs733618 with odds ratios (ORs) ranging from 0.27 to 0.45. In the asymptomatic microfilaremic cases, marker rs231775 exhibited a significant decreased risk, with ORs ranging from 0.50 to 0.57. The study has identified SNPs in the CTLA4 promoter gene that may be functionally linked with susceptibility to LF.
DOI: 10.1016/j.humimm.2011.03.017
PubMed: 21513760
Affiliations:
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Le document en format XML
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<term>Adult</term>
<term>Aged</term>
<term>Alleles</term>
<term>Antigens, CD (genetics)</term>
<term>Asian Continental Ancestry Group (genetics)</term>
<term>CTLA-4 Antigen</term>
<term>Case-Control Studies</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Elephantiasis, Filarial (genetics)</term>
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<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Humans</term>
<term>Malaysia</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Promoter Regions, Genetic (genetics)</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Allèles</term>
<term>Antigène CTLA-4</term>
<term>Antigènes CD (génétique)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Exons</term>
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<term>Filariose lymphatique (génétique)</term>
<term>Fréquence d'allèle</term>
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<term>Jeune adulte</term>
<term>Malaisie</term>
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<term>Polymorphisme de nucléotide simple (génétique)</term>
<term>Population d'origine asiatique (génétique)</term>
<term>Prédisposition génétique à une maladie</term>
<term>Régions promotrices (génétique) (génétique)</term>
<term>Sujet âgé</term>
<term>Études cas-témoins</term>
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<term>Polymorphism, Single Nucleotide</term>
<term>Promoter Regions, Genetic</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes CD</term>
<term>Filariose lymphatique</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Population d'origine asiatique</term>
<term>Régions promotrices (génétique)</term>
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<term>Adult</term>
<term>Aged</term>
<term>Alleles</term>
<term>CTLA-4 Antigen</term>
<term>Case-Control Studies</term>
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<term>Child, Preschool</term>
<term>Exons</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">Lymphatic filariasis (LF) is a parasitic disease caused by threadlike worms of the Brugia and Wuchereria species that live in the human lymphatic system. Regulatory T cells (Tregs) may play a key role in the pathogenesis of LF, and cytotoxic T-lymphocyte antigen-4 (CTLA4) expressed by Tregs is a potential candidate gene because it modulates T-cell activation. A case-control study was performed to establish a potential association of 5 CTLA4 gene promoter single nucleotide polymorphisms (SNPs; rs733618, rs11571316, rs5742909, rs231775, and rs16840252) with the occurrence of LF in an East Malaysian population (320 LF-infected individuals and 150 healthy controls). Polymorphisms were evaluated using TaqMan real-time polymerase chain reaction followed by direct sequencing. LF carriers of the rs733618 AG genotypes (p = 0.02) and those with combined minor allele G carriers (AG + GG; p = 0.01) exhibited a significantly decreased risk for LF. Among the asymptomatic amicrofilaremic cases, positive associations were reported for all genotypes and variants of rs733618 with odds ratios (ORs) ranging from 0.27 to 0.45. In the asymptomatic microfilaremic cases, marker rs231775 exhibited a significant decreased risk, with ORs ranging from 0.50 to 0.57. The study has identified SNPs in the CTLA4 promoter gene that may be functionally linked with susceptibility to LF.</div>
</front>
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<name sortKey="Mohd, Tajul Ariffin Awang" sort="Mohd, Tajul Ariffin Awang" uniqKey="Mohd T" first="Tajul Ariffin Awang" last="Mohd">Tajul Ariffin Awang Mohd</name>
<name sortKey="Muhi, Jamail" sort="Muhi, Jamail" uniqKey="Muhi J" first="Jamail" last="Muhi">Jamail Muhi</name>
<name sortKey="Noordin, Rahmah" sort="Noordin, Rahmah" uniqKey="Noordin R" first="Rahmah" last="Noordin">Rahmah Noordin</name>
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