Serveur d'exploration sur le lymphœdème

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Dirofilaria immitis encodes Di-nhr-7, a putative orthologue of the Drosophila ecdysone-regulated E78 gene.

Identifieur interne : 009473 ( Main/Exploration ); précédent : 009472; suivant : 009474

Dirofilaria immitis encodes Di-nhr-7, a putative orthologue of the Drosophila ecdysone-regulated E78 gene.

Auteurs : Kirsten Crossgrove [États-Unis] ; Vincent Laudet ; Claude V. Maina

Source :

RBID : pubmed:11814569

Descripteurs français

English descriptors

Abstract

Filarial parasites are responsible for several serious human diseases with symptoms such as lymphoedema, elephantiasis, and blindness. An understanding of how these parasites pass through developmental checkpoints may elucidate the general mechanisms of these illnesses and suggest potential targets for intervention. A useful model system for the study of human filariasis is the related nematode Dirofilaria immitis, the causative agent of dog heartworm disease. In D. immitis, molting from the third to the fourth larval stage can be induced in vitro by the insect hormone 20-OH ecdysone, suggesting that ecdysone, or some related hormone, may play a similar role in the development of D. immitis. Ecdysone has a well-characterized developmental role in insects, where it is involved in the control of molting and metamorphosis. We have identified a D. immitis orthologue of the Drosophila ecdysone response early gene E78, a member of the nuclear receptor (NR) superfamily. The D. immitis gene, Di-nhr-7 (NR1E1) encodes at least three isoforms, including two potential negative regulatory isoforms, and is expressed in a sex-specific manner. An MBP/Di-NHR-7 fusion protein is able to bind to DNA response elements that are recognized by the closely related mammalian NR Rev-erb(alpha).

PubMed: 11814569


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Dirofilaria immitis encodes Di-nhr-7, a putative orthologue of the Drosophila ecdysone-regulated E78 gene.</title>
<author>
<name sortKey="Crossgrove, Kirsten" sort="Crossgrove, Kirsten" uniqKey="Crossgrove K" first="Kirsten" last="Crossgrove">Kirsten Crossgrove</name>
<affiliation wicri:level="2">
<nlm:affiliation>New England Biolabs, Inc., Beverly, MA 01915, USA. kcrossgrove@loyola.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>New England Biolabs, Inc., Beverly, MA 01915</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Laudet, Vincent" sort="Laudet, Vincent" uniqKey="Laudet V" first="Vincent" last="Laudet">Vincent Laudet</name>
</author>
<author>
<name sortKey="Maina, Claude V" sort="Maina, Claude V" uniqKey="Maina C" first="Claude V" last="Maina">Claude V. Maina</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2002">2002</date>
<idno type="RBID">pubmed:11814569</idno>
<idno type="pmid">11814569</idno>
<idno type="wicri:Area/PubMed/Corpus">004665</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004665</idno>
<idno type="wicri:Area/PubMed/Curation">004665</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004665</idno>
<idno type="wicri:Area/PubMed/Checkpoint">004665</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004665</idno>
<idno type="wicri:Area/Ncbi/Merge">000862</idno>
<idno type="wicri:Area/Ncbi/Curation">000862</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000862</idno>
<idno type="wicri:doubleKey">0166-6851:2002:Crossgrove K:dirofilaria:immitis:encodes</idno>
<idno type="wicri:Area/Main/Merge">009839</idno>
<idno type="wicri:Area/Main/Curation">009473</idno>
<idno type="wicri:Area/Main/Exploration">009473</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Dirofilaria immitis encodes Di-nhr-7, a putative orthologue of the Drosophila ecdysone-regulated E78 gene.</title>
<author>
<name sortKey="Crossgrove, Kirsten" sort="Crossgrove, Kirsten" uniqKey="Crossgrove K" first="Kirsten" last="Crossgrove">Kirsten Crossgrove</name>
<affiliation wicri:level="2">
<nlm:affiliation>New England Biolabs, Inc., Beverly, MA 01915, USA. kcrossgrove@loyola.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>New England Biolabs, Inc., Beverly, MA 01915</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Laudet, Vincent" sort="Laudet, Vincent" uniqKey="Laudet V" first="Vincent" last="Laudet">Vincent Laudet</name>
</author>
<author>
<name sortKey="Maina, Claude V" sort="Maina, Claude V" uniqKey="Maina C" first="Claude V" last="Maina">Claude V. Maina</name>
</author>
</analytic>
<series>
<title level="j">Molecular and biochemical parasitology</title>
<idno type="ISSN">0166-6851</idno>
<imprint>
<date when="2002" type="published">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Cloning, Molecular</term>
<term>DNA-Binding Proteins (metabolism)</term>
<term>Dirofilaria immitis (genetics)</term>
<term>Dirofilariasis (parasitology)</term>
<term>Drosophila (chemistry)</term>
<term>Drosophila (genetics)</term>
<term>Drosophila Proteins</term>
<term>Electrophoretic Mobility Shift Assay</term>
<term>Female</term>
<term>Helminth Proteins (chemistry)</term>
<term>Helminth Proteins (genetics)</term>
<term>Helminth Proteins (metabolism)</term>
<term>Molecular Sequence Data</term>
<term>Molting (genetics)</term>
<term>Oogenesis (genetics)</term>
<term>Phylogeny</term>
<term>Protein Isoforms (chemistry)</term>
<term>Protein Isoforms (genetics)</term>
<term>RNA, Messenger (metabolism)</term>
<term>Receptors, Cytoplasmic and Nuclear (chemistry)</term>
<term>Receptors, Cytoplasmic and Nuclear (genetics)</term>
<term>Receptors, Cytoplasmic and Nuclear (metabolism)</term>
<term>Receptors, Thyroid Hormone</term>
<term>Response Elements (genetics)</term>
<term>Sequence Alignment</term>
<term>Sequence Homology, Amino Acid</term>
<term>Sex Characteristics</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>ARN messager (métabolisme)</term>
<term>Alignement de séquences</term>
<term>Animaux</term>
<term>Caractères sexuels</term>
<term>Clonage moléculaire</term>
<term>Dirofilaria immitis (génétique)</term>
<term>Dirofilariose (parasitologie)</term>
<term>Données de séquences moléculaires</term>
<term>Drosophila ()</term>
<term>Drosophila (génétique)</term>
<term>Femelle</term>
<term>Isoformes de protéines ()</term>
<term>Isoformes de protéines (génétique)</term>
<term>Mue (génétique)</term>
<term>Ovogenèse (génétique)</term>
<term>Phylogénie</term>
<term>Protéines d'helminthes ()</term>
<term>Protéines d'helminthes (génétique)</term>
<term>Protéines d'helminthes (métabolisme)</term>
<term>Protéines de Drosophila</term>
<term>Protéines de liaison à l'ADN (métabolisme)</term>
<term>Récepteurs cytoplasmiques et nucléaires ()</term>
<term>Récepteurs cytoplasmiques et nucléaires (génétique)</term>
<term>Récepteurs cytoplasmiques et nucléaires (métabolisme)</term>
<term>Récepteurs des hormones thyroïdiennes</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Séquence d'acides aminés</term>
<term>Test de retard de migration électrophorétique</term>
<term>Éléments de réponse (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en">
<term>Helminth Proteins</term>
<term>Protein Isoforms</term>
<term>Receptors, Cytoplasmic and Nuclear</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>Helminth Proteins</term>
<term>Protein Isoforms</term>
<term>Receptors, Cytoplasmic and Nuclear</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>DNA-Binding Proteins</term>
<term>Helminth Proteins</term>
<term>RNA, Messenger</term>
<term>Receptors, Cytoplasmic and Nuclear</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en">
<term>Drosophila</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Dirofilaria immitis</term>
<term>Drosophila</term>
<term>Molting</term>
<term>Oogenesis</term>
<term>Response Elements</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Dirofilaria immitis</term>
<term>Drosophila</term>
<term>Isoformes de protéines</term>
<term>Mue</term>
<term>Ovogenèse</term>
<term>Protéines d'helminthes</term>
<term>Récepteurs cytoplasmiques et nucléaires</term>
<term>Éléments de réponse</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr">
<term>ARN messager</term>
<term>Protéines d'helminthes</term>
<term>Protéines de liaison à l'ADN</term>
<term>Récepteurs cytoplasmiques et nucléaires</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr">
<term>Dirofilariose</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en">
<term>Dirofilariasis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Cloning, Molecular</term>
<term>Drosophila Proteins</term>
<term>Electrophoretic Mobility Shift Assay</term>
<term>Female</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Receptors, Thyroid Hormone</term>
<term>Sequence Alignment</term>
<term>Sequence Homology, Amino Acid</term>
<term>Sex Characteristics</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Alignement de séquences</term>
<term>Animaux</term>
<term>Caractères sexuels</term>
<term>Clonage moléculaire</term>
<term>Données de séquences moléculaires</term>
<term>Drosophila</term>
<term>Femelle</term>
<term>Isoformes de protéines</term>
<term>Phylogénie</term>
<term>Protéines d'helminthes</term>
<term>Protéines de Drosophila</term>
<term>Récepteurs cytoplasmiques et nucléaires</term>
<term>Récepteurs des hormones thyroïdiennes</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Séquence d'acides aminés</term>
<term>Test de retard de migration électrophorétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Filarial parasites are responsible for several serious human diseases with symptoms such as lymphoedema, elephantiasis, and blindness. An understanding of how these parasites pass through developmental checkpoints may elucidate the general mechanisms of these illnesses and suggest potential targets for intervention. A useful model system for the study of human filariasis is the related nematode Dirofilaria immitis, the causative agent of dog heartworm disease. In D. immitis, molting from the third to the fourth larval stage can be induced in vitro by the insect hormone 20-OH ecdysone, suggesting that ecdysone, or some related hormone, may play a similar role in the development of D. immitis. Ecdysone has a well-characterized developmental role in insects, where it is involved in the control of molting and metamorphosis. We have identified a D. immitis orthologue of the Drosophila ecdysone response early gene E78, a member of the nuclear receptor (NR) superfamily. The D. immitis gene, Di-nhr-7 (NR1E1) encodes at least three isoforms, including two potential negative regulatory isoforms, and is expressed in a sex-specific manner. An MBP/Di-NHR-7 fusion protein is able to bind to DNA response elements that are recognized by the closely related mammalian NR Rev-erb(alpha).</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>États-Unis</li>
</country>
<region>
<li>Massachusetts</li>
</region>
</list>
<tree>
<noCountry>
<name sortKey="Laudet, Vincent" sort="Laudet, Vincent" uniqKey="Laudet V" first="Vincent" last="Laudet">Vincent Laudet</name>
<name sortKey="Maina, Claude V" sort="Maina, Claude V" uniqKey="Maina C" first="Claude V" last="Maina">Claude V. Maina</name>
</noCountry>
<country name="États-Unis">
<region name="Massachusetts">
<name sortKey="Crossgrove, Kirsten" sort="Crossgrove, Kirsten" uniqKey="Crossgrove K" first="Kirsten" last="Crossgrove">Kirsten Crossgrove</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 009473 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 009473 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:11814569
   |texte=   Dirofilaria immitis encodes Di-nhr-7, a putative orthologue of the Drosophila ecdysone-regulated E78 gene.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:11814569" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1 

Wicri

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024