Dirofilaria immitis encodes Di-nhr-7, a putative orthologue of the Drosophila ecdysone-regulated E78 gene.
Identifieur interne : 004665 ( PubMed/Curation ); précédent : 004664; suivant : 004666Dirofilaria immitis encodes Di-nhr-7, a putative orthologue of the Drosophila ecdysone-regulated E78 gene.
Auteurs : Kirsten Crossgrove [États-Unis] ; Vincent Laudet ; Claude V. MainaSource :
- Molecular and biochemical parasitology [ 0166-6851 ] ; 2002.
Descripteurs français
- KwdFr :
- ARN messager (métabolisme), Alignement de séquences, Animaux, Caractères sexuels, Clonage moléculaire, Dirofilaria immitis (génétique), Dirofilariose (parasitologie), Données de séquences moléculaires, Drosophila (), Drosophila (génétique), Femelle, Isoformes de protéines (), Isoformes de protéines (génétique), Mue (génétique), Ovogenèse (génétique), Phylogénie, Protéines d'helminthes (), Protéines d'helminthes (génétique), Protéines d'helminthes (métabolisme), Protéines de Drosophila, Protéines de liaison à l'ADN (métabolisme), Récepteurs cytoplasmiques et nucléaires (), Récepteurs cytoplasmiques et nucléaires (génétique), Récepteurs cytoplasmiques et nucléaires (métabolisme), Récepteurs des hormones thyroïdiennes, Similitude de séquences d'acides aminés, Séquence d'acides aminés, Test de retard de migration électrophorétique, Éléments de réponse (génétique).
- MESH :
- génétique : Dirofilaria immitis, Drosophila, Isoformes de protéines, Mue, Ovogenèse, Protéines d'helminthes, Récepteurs cytoplasmiques et nucléaires, Éléments de réponse.
- métabolisme : ARN messager, Protéines d'helminthes, Protéines de liaison à l'ADN, Récepteurs cytoplasmiques et nucléaires.
- parasitologie : Dirofilariose.
- Alignement de séquences, Animaux, Caractères sexuels, Clonage moléculaire, Données de séquences moléculaires, Drosophila, Femelle, Isoformes de protéines, Phylogénie, Protéines d'helminthes, Protéines de Drosophila, Récepteurs cytoplasmiques et nucléaires, Récepteurs des hormones thyroïdiennes, Similitude de séquences d'acides aminés, Séquence d'acides aminés, Test de retard de migration électrophorétique.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Cloning, Molecular, DNA-Binding Proteins (metabolism), Dirofilaria immitis (genetics), Dirofilariasis (parasitology), Drosophila (chemistry), Drosophila (genetics), Drosophila Proteins, Electrophoretic Mobility Shift Assay, Female, Helminth Proteins (chemistry), Helminth Proteins (genetics), Helminth Proteins (metabolism), Molecular Sequence Data, Molting (genetics), Oogenesis (genetics), Phylogeny, Protein Isoforms (chemistry), Protein Isoforms (genetics), RNA, Messenger (metabolism), Receptors, Cytoplasmic and Nuclear (chemistry), Receptors, Cytoplasmic and Nuclear (genetics), Receptors, Cytoplasmic and Nuclear (metabolism), Receptors, Thyroid Hormone, Response Elements (genetics), Sequence Alignment, Sequence Homology, Amino Acid, Sex Characteristics.
- MESH :
- chemical , chemistry : Helminth Proteins, Protein Isoforms, Receptors, Cytoplasmic and Nuclear.
- chemical , genetics : Helminth Proteins, Protein Isoforms, Receptors, Cytoplasmic and Nuclear.
- chemical , metabolism : DNA-Binding Proteins, Helminth Proteins, RNA, Messenger, Receptors, Cytoplasmic and Nuclear.
- chemistry : Drosophila.
- genetics : Dirofilaria immitis, Drosophila, Molting, Oogenesis, Response Elements.
- parasitology : Dirofilariasis.
- Amino Acid Sequence, Animals, Cloning, Molecular, Drosophila Proteins, Electrophoretic Mobility Shift Assay, Female, Molecular Sequence Data, Phylogeny, Receptors, Thyroid Hormone, Sequence Alignment, Sequence Homology, Amino Acid, Sex Characteristics.
Abstract
Filarial parasites are responsible for several serious human diseases with symptoms such as lymphoedema, elephantiasis, and blindness. An understanding of how these parasites pass through developmental checkpoints may elucidate the general mechanisms of these illnesses and suggest potential targets for intervention. A useful model system for the study of human filariasis is the related nematode Dirofilaria immitis, the causative agent of dog heartworm disease. In D. immitis, molting from the third to the fourth larval stage can be induced in vitro by the insect hormone 20-OH ecdysone, suggesting that ecdysone, or some related hormone, may play a similar role in the development of D. immitis. Ecdysone has a well-characterized developmental role in insects, where it is involved in the control of molting and metamorphosis. We have identified a D. immitis orthologue of the Drosophila ecdysone response early gene E78, a member of the nuclear receptor (NR) superfamily. The D. immitis gene, Di-nhr-7 (NR1E1) encodes at least three isoforms, including two potential negative regulatory isoforms, and is expressed in a sex-specific manner. An MBP/Di-NHR-7 fusion protein is able to bind to DNA response elements that are recognized by the closely related mammalian NR Rev-erb(alpha).
PubMed: 11814569
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An understanding of how these parasites pass through developmental checkpoints may elucidate the general mechanisms of these illnesses and suggest potential targets for intervention. A useful model system for the study of human filariasis is the related nematode Dirofilaria immitis, the causative agent of dog heartworm disease. In D. immitis, molting from the third to the fourth larval stage can be induced in vitro by the insect hormone 20-OH ecdysone, suggesting that ecdysone, or some related hormone, may play a similar role in the development of D. immitis. Ecdysone has a well-characterized developmental role in insects, where it is involved in the control of molting and metamorphosis. We have identified a D. immitis orthologue of the Drosophila ecdysone response early gene E78, a member of the nuclear receptor (NR) superfamily. The D. immitis gene, Di-nhr-7 (NR1E1) encodes at least three isoforms, including two potential negative regulatory isoforms, and is expressed in a sex-specific manner. An MBP/Di-NHR-7 fusion protein is able to bind to DNA response elements that are recognized by the closely related mammalian NR Rev-erb(alpha).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11814569</PMID><DateCreated><Year>2002</Year><Month>01</Month><Day>29</Day></DateCreated><DateCompleted><Year>2002</Year><Month>04</Month><Day>16</Day></DateCompleted><DateRevised><Year>2004</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0166-6851</ISSN><JournalIssue CitedMedium="Print"><Volume>119</Volume><Issue>2</Issue><PubDate><Year>2002</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Molecular and biochemical parasitology</Title><ISOAbbreviation>Mol. Biochem. Parasitol.</ISOAbbreviation></Journal><ArticleTitle>Dirofilaria immitis encodes Di-nhr-7, a putative orthologue of the Drosophila ecdysone-regulated E78 gene.</ArticleTitle><Pagination><MedlinePgn>169-77</MedlinePgn></Pagination><Abstract><AbstractText>Filarial parasites are responsible for several serious human diseases with symptoms such as lymphoedema, elephantiasis, and blindness. An understanding of how these parasites pass through developmental checkpoints may elucidate the general mechanisms of these illnesses and suggest potential targets for intervention. A useful model system for the study of human filariasis is the related nematode Dirofilaria immitis, the causative agent of dog heartworm disease. In D. immitis, molting from the third to the fourth larval stage can be induced in vitro by the insect hormone 20-OH ecdysone, suggesting that ecdysone, or some related hormone, may play a similar role in the development of D. immitis. Ecdysone has a well-characterized developmental role in insects, where it is involved in the control of molting and metamorphosis. We have identified a D. immitis orthologue of the Drosophila ecdysone response early gene E78, a member of the nuclear receptor (NR) superfamily. The D. immitis gene, Di-nhr-7 (NR1E1) encodes at least three isoforms, including two potential negative regulatory isoforms, and is expressed in a sex-specific manner. An MBP/Di-NHR-7 fusion protein is able to bind to DNA response elements that are recognized by the closely related mammalian NR Rev-erb(alpha).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Crossgrove</LastName><ForeName>Kirsten</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>New England Biolabs, Inc., Beverly, MA 01915, USA. kcrossgrove@loyola.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laudet</LastName><ForeName>Vincent</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Maina</LastName><ForeName>Claude V</ForeName><Initials>CV</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName><AccessionNumberList><AccessionNumber>AF367206</AccessionNumber><AccessionNumber>AF367207</AccessionNumber><AccessionNumber>AF367208</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Mol Biochem Parasitol</MedlineTA><NlmUniqueID>8006324</NlmUniqueID><ISSNLinking>0166-6851</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004268">DNA-Binding Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029721">Drosophila Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C083810">E78 protein, Drosophila</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015801">Helminth Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C451424">NHR-7 protein, Dirofilaria immitis</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020033">Protein Isoforms</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018160">Receptors, Cytoplasmic and Nuclear</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011988">Receptors, Thyroid Hormone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003001" MajorTopicYN="N">Cloning, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004268" MajorTopicYN="N">DNA-Binding Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004183" MajorTopicYN="N">Dirofilaria immitis</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004184" MajorTopicYN="N">Dirofilariasis</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004330" MajorTopicYN="N">Drosophila</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029721" MajorTopicYN="Y">Drosophila Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024202" MajorTopicYN="N">Electrophoretic Mobility Shift Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015801" MajorTopicYN="N">Helminth Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018978" MajorTopicYN="N">Molting</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009866" MajorTopicYN="N">Oogenesis</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020033" MajorTopicYN="N">Protein Isoforms</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018160" MajorTopicYN="N">Receptors, Cytoplasmic and Nuclear</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011988" MajorTopicYN="Y">Receptors, Thyroid Hormone</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020218" MajorTopicYN="N">Response Elements</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016415" MajorTopicYN="N">Sequence Alignment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017386" MajorTopicYN="N">Sequence Homology, Amino Acid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012727" MajorTopicYN="N">Sex Characteristics</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>1</Month><Day>30</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>4</Month><Day>17</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>1</Month><Day>30</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11814569</ArticleId><ArticleId IdType="pii">S0166685101004121</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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