LymphedemaV1, Main, Exploration, bibRecordById, Pascal:96-0478655

The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs

Identifieur interne : 00C189 ( Main/Exploration ); précédent : 00C188; suivant : 00C190

The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs

Auteurs : T. S. Chang [République populaire de Chine] ; J. L. Gan [République populaire de Chine] ; K. D. Fu [République populaire de Chine] ; W. Y. Huang [République populaire de Chine]

Source :

Lymphology [ 0024-7766 ] ; 1996.

RBID : Pascal:96-0478655

Descripteurs français

KwdFr :
- Administration par voie orale, Adulte, Anticoagulants (usage thérapeutique), Association thérapeutique, Bandages, Coumarines (usage thérapeutique), Femelle, Humains, Hyperthermie provoquée, Jambe, Lymphoedème (), Maladie chronique, Micro-ondes, Mâle, Méthode en double aveugle, Résultat thérapeutique, Études de suivi.
MESH :
- usage thérapeutique : Anticoagulants, Coumarines.
Pascal (Inist)
- Administration par voie orale, Adulte, Association thérapeutique, Bandages, Femelle, Humains, Hyperthermie provoquée, Jambe, Lymphoedème, Coumarine, Chauffage, Hyperfréquence, Chimiothérapie, Maladie chronique, Micro-ondes, Mâle, Méthode en double aveugle, Résultat thérapeutique, Traitement, Association, Homme, Anticoagulant, Études de suivi.
Wicri :
- topic : Chauffage, Association, Homme.

English descriptors

KwdEn :
- Administration, Oral, Adult, Anticoagulant, Anticoagulants (therapeutic use), Association, Bandages, Chemotherapy, Chronic Disease, Combined Modality Therapy, Coumarin, Coumarins (therapeutic use), Double-Blind Method, Female, Follow-Up Studies, Heating, Human, Humans, Hyperthermia, Induced, Leg, Lymphedema, Lymphedema (therapy), Male, Microwave, Microwaves, Treatment, Treatment Outcome.
MESH :
- chemical , therapeutic use : Anticoagulants, Coumarins.
- therapy : Lymphedema.
- Administration, Oral, Adult, Bandages, Chronic Disease, Combined Modality Therapy, Double-Blind Method, Female, Follow-Up Studies, Humans, Hyperthermia, Induced, Leg, Male, Microwaves, Treatment Outcome.

Abstract

Sixty patients with leg lymph edema from a variety of etiologies were divided into randomized two groups, matched by Grade, duration, age, sex, and cause of lymph edema. Using a double-blind format, one group received 5,6 benzo-[α]-pyrone (coumarin 1,2 benzopyrone, 400 mg/day) for six months ; the other received a placebo. For the next six months, both groups received a standardized regimen of heat (using microwaves) coupled with compression garments. Benzopyrone produced approximately 20% reduction in the volume (p=10^-4) and improvement in circumferences and tonometry (p=10^-5 and 10^-7). Symptoms (feelings of swelling, pain, heaviness and loss of mobility) were also significantly improved (p=0.03 to 10^-7). During the second six months, when microwave heat therapy was added to drug therapy, the patients who had previously received the placebo showed significant improvement (p=0.03 to 10^-9) in signs and symptoms of lymph edema. Some, but not all, of the group that was receiving benzopyrones were also significantly improved by heat therapy (p=0.8 to 0.002). Taking benzopyrones for 12 months plus heat treatment for six months was significantly better, for some criteria, than the placebo plus heat therapy (p=0.7 to 0.04). On the other hand, heat plus either placebo or benzopyrone was often significantly better than either the active or inactive drug without heat (p=0.8 to 10^-9).

Affiliations:

République populaire de Chine

Le document en format XML

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<author><name sortKey="Chang, T S" sort="Chang, T S" uniqKey="Chang T" first="T. S." last="Chang">T. S. Chang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University</s1>
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<author><name sortKey="Huang, W Y" sort="Huang, W Y" uniqKey="Huang W" first="W. Y." last="Huang">W. Y. Huang</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs</title>
<author><name sortKey="Chang, T S" sort="Chang, T S" uniqKey="Chang T" first="T. S." last="Chang">T. S. Chang</name>
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<author><name sortKey="Gan, J L" sort="Gan, J L" uniqKey="Gan J" first="J. L." last="Gan">J. L. Gan</name>
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<author><name sortKey="Fu, K D" sort="Fu, K D" uniqKey="Fu K" first="K. D." last="Fu">K. D. Fu</name>
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<author><name sortKey="Huang, W Y" sort="Huang, W Y" uniqKey="Huang W" first="W. Y." last="Huang">W. Y. Huang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University</s1>
<s2>Shanghai</s2>
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<sZ>2 aut.</sZ>
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<series><title level="j" type="main">Lymphology</title>
<title level="j" type="abbreviated">Lymphology</title>
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<imprint><date when="1996">1996</date>
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<term>Adult</term>
<term>Anticoagulant</term>
<term>Anticoagulants (therapeutic use)</term>
<term>Association</term>
<term>Bandages</term>
<term>Chemotherapy</term>
<term>Chronic Disease</term>
<term>Combined Modality Therapy</term>
<term>Coumarin</term>
<term>Coumarins (therapeutic use)</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Heating</term>
<term>Human</term>
<term>Humans</term>
<term>Hyperthermia, Induced</term>
<term>Leg</term>
<term>Lymphedema</term>
<term>Lymphedema (therapy)</term>
<term>Male</term>
<term>Microwave</term>
<term>Microwaves</term>
<term>Treatment</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie orale</term>
<term>Adulte</term>
<term>Anticoagulants (usage thérapeutique)</term>
<term>Association thérapeutique</term>
<term>Bandages</term>
<term>Coumarines (usage thérapeutique)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hyperthermie provoquée</term>
<term>Jambe</term>
<term>Lymphoedème ()</term>
<term>Maladie chronique</term>
<term>Micro-ondes</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Résultat thérapeutique</term>
<term>Études de suivi</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anticoagulants</term>
<term>Coumarins</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticoagulants</term>
<term>Coumarines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term>
<term>Adult</term>
<term>Bandages</term>
<term>Chronic Disease</term>
<term>Combined Modality Therapy</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Hyperthermia, Induced</term>
<term>Leg</term>
<term>Male</term>
<term>Microwaves</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Administration par voie orale</term>
<term>Adulte</term>
<term>Association thérapeutique</term>
<term>Bandages</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hyperthermie provoquée</term>
<term>Jambe</term>
<term>Lymphoedème</term>
<term>Coumarine</term>
<term>Chauffage</term>
<term>Hyperfréquence</term>
<term>Chimiothérapie</term>
<term>Maladie chronique</term>
<term>Micro-ondes</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Résultat thérapeutique</term>
<term>Traitement</term>
<term>Association</term>
<term>Homme</term>
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<term>Études de suivi</term>
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<front><div type="abstract" xml:lang="en">Sixty patients with leg lymph edema from a variety of etiologies were divided into randomized two groups, matched by Grade, duration, age, sex, and cause of lymph edema. Using a double-blind format, one group received 5,6 benzo-[α]-pyrone (coumarin 1,2 benzopyrone, 400 mg/day) for six months ; the other received a placebo. For the next six months, both groups received a standardized regimen of heat (using microwaves) coupled with compression garments. Benzopyrone produced approximately 20% reduction in the volume (p=10<sup>-4</sup>
) and improvement in circumferences and tonometry (p=10<sup>-5</sup>
 and 10<sup>-7</sup>
). Symptoms (feelings of swelling, pain, heaviness and loss of mobility) were also significantly improved (p=0.03 to 10<sup>-7</sup>
). During the second six months, when microwave heat therapy was added to drug therapy, the patients who had previously received the placebo showed significant improvement (p=0.03 to 10<sup>-9</sup>
) in signs and symptoms of lymph edema. Some, but not all, of the group that was receiving benzopyrones were also significantly improved by heat therapy (p=0.8 to 0.002). Taking benzopyrones for 12 months plus heat treatment for six months was significantly better, for some criteria, than the placebo plus heat therapy (p=0.7 to 0.04). On the other hand, heat plus either placebo or benzopyrone was often significantly better than either the active or inactive drug without heat (p=0.8 to 10<sup>-9</sup>
).</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Chang, T S" sort="Chang, T S" uniqKey="Chang T" first="T. S." last="Chang">T. S. Chang</name>
</noRegion>
<name sortKey="Fu, K D" sort="Fu, K D" uniqKey="Fu K" first="K. D." last="Fu">K. D. Fu</name>
<name sortKey="Gan, J L" sort="Gan, J L" uniqKey="Gan J" first="J. L." last="Gan">J. L. Gan</name>
<name sortKey="Huang, W Y" sort="Huang, W Y" uniqKey="Huang W" first="W. Y." last="Huang">W. Y. Huang</name>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur le lymphœdème

The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs

The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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