The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs
Identifieur interne : 000B73 ( PascalFrancis/Checkpoint ); précédent : 000B72; suivant : 000B74The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs
Auteurs : T. S. Chang [République populaire de Chine] ; J. L. Gan [République populaire de Chine] ; K. D. Fu [République populaire de Chine] ; W. Y. Huang [République populaire de Chine]Source :
- Lymphology [ 0024-7766 ] ; 1996.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Chauffage, Association, Homme.
English descriptors
- KwdEn :
Abstract
Sixty patients with leg lymph edema from a variety of etiologies were divided into randomized two groups, matched by Grade, duration, age, sex, and cause of lymph edema. Using a double-blind format, one group received 5,6 benzo-[α]-pyrone (coumarin 1,2 benzopyrone, 400 mg/day) for six months ; the other received a placebo. For the next six months, both groups received a standardized regimen of heat (using microwaves) coupled with compression garments. Benzopyrone produced approximately 20% reduction in the volume (p=10-4) and improvement in circumferences and tonometry (p=10-5 and 10-7). Symptoms (feelings of swelling, pain, heaviness and loss of mobility) were also significantly improved (p=0.03 to 10-7). During the second six months, when microwave heat therapy was added to drug therapy, the patients who had previously received the placebo showed significant improvement (p=0.03 to 10-9) in signs and symptoms of lymph edema. Some, but not all, of the group that was receiving benzopyrones were also significantly improved by heat therapy (p=0.8 to 0.002). Taking benzopyrones for 12 months plus heat treatment for six months was significantly better, for some criteria, than the placebo plus heat therapy (p=0.7 to 0.04). On the other hand, heat plus either placebo or benzopyrone was often significantly better than either the active or inactive drug without heat (p=0.8 to 10-9).
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs</title><author><name sortKey="Chang, T S" sort="Chang, T S" uniqKey="Chang T" first="T. S." last="Chang">T. S. Chang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Gan, J L" sort="Gan, J L" uniqKey="Gan J" first="J. L." last="Gan">J. L. Gan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Fu, K D" sort="Fu, K D" uniqKey="Fu K" first="K. D." last="Fu">K. D. Fu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Huang, W Y" sort="Huang, W Y" uniqKey="Huang W" first="W. Y." last="Huang">W. Y. Huang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">96-0478655</idno><date when="1996">1996</date><idno type="stanalyst">PASCAL 96-0478655 INIST</idno><idno type="RBID">Pascal:96-0478655</idno><idno type="wicri:Area/PascalFrancis/Corpus">000B78</idno><idno type="wicri:Area/PascalFrancis/Curation">000F30</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000B73</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000B73</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs</title><author><name sortKey="Chang, T S" sort="Chang, T S" uniqKey="Chang T" first="T. S." last="Chang">T. S. Chang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Gan, J L" sort="Gan, J L" uniqKey="Gan J" first="J. L." last="Gan">J. L. Gan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Fu, K D" sort="Fu, K D" uniqKey="Fu K" first="K. D." last="Fu">K. D. Fu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Huang, W Y" sort="Huang, W Y" uniqKey="Huang W" first="W. Y." last="Huang">W. Y. Huang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Lymphology</title><title level="j" type="abbreviated">Lymphology</title><idno type="ISSN">0024-7766</idno><imprint><date when="1996">1996</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Lymphology</title><title level="j" type="abbreviated">Lymphology</title><idno type="ISSN">0024-7766</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anticoagulant</term><term>Association</term><term>Chemotherapy</term><term>Coumarin</term><term>Heating</term><term>Human</term><term>Lymphedema</term><term>Microwave</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Lymphoedème</term><term>Coumarine</term><term>Chauffage</term><term>Hyperfréquence</term><term>Chimiothérapie</term><term>Traitement</term><term>Association</term><term>Homme</term><term>Anticoagulant</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chauffage</term><term>Association</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sixty patients with leg lymph edema from a variety of etiologies were divided into randomized two groups, matched by Grade, duration, age, sex, and cause of lymph edema. Using a double-blind format, one group received 5,6 benzo-[α]-pyrone (coumarin 1,2 benzopyrone, 400 mg/day) for six months ; the other received a placebo. For the next six months, both groups received a standardized regimen of heat (using microwaves) coupled with compression garments. Benzopyrone produced approximately 20% reduction in the volume (p=10<sup>-4</sup>) and improvement in circumferences and tonometry (p=10<sup>-5</sup> and 10<sup>-7</sup>). Symptoms (feelings of swelling, pain, heaviness and loss of mobility) were also significantly improved (p=0.03 to 10<sup>-7</sup>). During the second six months, when microwave heat therapy was added to drug therapy, the patients who had previously received the placebo showed significant improvement (p=0.03 to 10<sup>-9</sup>) in signs and symptoms of lymph edema. Some, but not all, of the group that was receiving benzopyrones were also significantly improved by heat therapy (p=0.8 to 0.002). Taking benzopyrones for 12 months plus heat treatment for six months was significantly better, for some criteria, than the placebo plus heat therapy (p=0.7 to 0.04). On the other hand, heat plus either placebo or benzopyrone was often significantly better than either the active or inactive drug without heat (p=0.8 to 10<sup>-9</sup>).</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0024-7766</s0></fA01><fA02 i1="01"><s0>LYMPBN</s0></fA02><fA03 i2="1"><s0>Lymphology</s0></fA03><fA05><s2>29</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs</s1></fA08><fA11 i1="01" i2="1"><s1>CHANG (T. S.)</s1></fA11><fA11 i1="02" i2="1"><s1>GAN (J. L.)</s1></fA11><fA11 i1="03" i2="1"><s1>FU (K. D.)</s1></fA11><fA11 i1="04" i2="1"><s1>HUANG (W. Y.)</s1></fA11><fA14 i1="01"><s1>Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></fA14><fA20><s1>106-111</s1></fA20><fA21><s1>1996</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>14604</s2><s5>354000066575310030</s5></fA43><fA44><s0>0000</s0><s1>© 1996 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>17 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>96-0478655</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Lymphology</s0></fA64><fA66 i1="01"><s0>INT</s0></fA66><fC01 i1="01" l="ENG"><s0>Sixty patients with leg lymph edema from a variety of etiologies were divided into randomized two groups, matched by Grade, duration, age, sex, and cause of lymph edema. Using a double-blind format, one group received 5,6 benzo-[α]-pyrone (coumarin 1,2 benzopyrone, 400 mg/day) for six months ; the other received a placebo. For the next six months, both groups received a standardized regimen of heat (using microwaves) coupled with compression garments. Benzopyrone produced approximately 20% reduction in the volume (p=10<sup>-4</sup>) and improvement in circumferences and tonometry (p=10<sup>-5</sup> and 10<sup>-7</sup>). Symptoms (feelings of swelling, pain, heaviness and loss of mobility) were also significantly improved (p=0.03 to 10<sup>-7</sup>). During the second six months, when microwave heat therapy was added to drug therapy, the patients who had previously received the placebo showed significant improvement (p=0.03 to 10<sup>-9</sup>) in signs and symptoms of lymph edema. Some, but not all, of the group that was receiving benzopyrones were also significantly improved by heat therapy (p=0.8 to 0.002). Taking benzopyrones for 12 months plus heat treatment for six months was significantly better, for some criteria, than the placebo plus heat therapy (p=0.7 to 0.04). On the other hand, heat plus either placebo or benzopyrone was often significantly better than either the active or inactive drug without heat (p=0.8 to 10<sup>-9</sup>).</s0></fC01><fC02 i1="01" i2="X"><s0>002B02G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Lymphoedème</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Lymphedema</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Linfedema</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Coumarine</s0><s2>NK</s2><s5>04</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Coumarin</s0><s2>NK</s2><s5>04</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Chauffage</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Heating</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="GER"><s0>Erhitzen</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Calefacción</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Hyperfréquence</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Microwave</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="GER"><s0>Mikrowelle</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Hiperfrecuencia</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Chimiothérapie</s0><s5>16</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Chemotherapy</s0><s5>16</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Quimioterapia</s0><s5>16</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Traitement</s0><s5>17</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Treatment</s0><s5>17</s5></fC03><fC03 i1="06" i2="X" l="GER"><s0>Aufbereiten</s0><s5>17</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Tratamiento</s0><s5>17</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Association</s0><s5>18</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Association</s0><s5>18</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Asociación</s0><s5>18</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Homme</s0><s5>20</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Human</s0><s5>20</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Hombre</s0><s5>20</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Anticoagulant</s0><s5>27</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Anticoagulant</s0><s5>27</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Anticoagulante</s0><s5>27</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Appareil circulatoire pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cardiovascular disease</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Lymphatique pathologie</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Lymphatic vessel disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Linfático patología</s0><s5>38</s5></fC07><fN21><s1>330</s1></fN21></pA></standard></inist><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Chang, T S" sort="Chang, T S" uniqKey="Chang T" first="T. S." last="Chang">T. S. Chang</name></noRegion><name sortKey="Fu, K D" sort="Fu, K D" uniqKey="Fu K" first="K. D." last="Fu">K. D. Fu</name><name sortKey="Gan, J L" sort="Gan, J L" uniqKey="Gan J" first="J. L." last="Gan">J. L. Gan</name><name sortKey="Huang, W Y" sort="Huang, W Y" uniqKey="Huang W" first="W. Y." last="Huang">W. Y. Huang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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