Tie1 is required for lymphatic valve and collecting vessel development
Identifieur interne : 001685 ( Main/Exploration ); précédent : 001684; suivant : 001686Tie1 is required for lymphatic valve and collecting vessel development
Auteurs : Xianghu Qu [États-Unis] ; Bin Zhou [États-Unis] ; H. Scott Baldwin [États-Unis]Source :
- Developmental biology [ 0012-1606 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Animaux nouveau-nés, Embryon de mammifère (embryologie), Embryon de mammifère (métabolisme), Immunohistochimie, Lymphangiogenèse (génétique), RT-PCR, Récepteur TIE-1 (génétique), Récepteur TIE-1 (métabolisme), Régulation de l'expression des gènes au cours du développement, Souris de lignée C57BL, Souris knockout, Système lymphatique (embryologie), Système lymphatique (métabolisme), Vaisseaux lymphatiques (embryologie), Vaisseaux lymphatiques (métabolisme).
- MESH :
- embryologie : Embryon de mammifère, Système lymphatique, Vaisseaux lymphatiques.
- génétique : Lymphangiogenèse, Récepteur TIE-1.
- métabolisme : Embryon de mammifère, Récepteur TIE-1, Système lymphatique, Vaisseaux lymphatiques.
- Animaux, Animaux nouveau-nés, Immunohistochimie, RT-PCR, Régulation de l'expression des gènes au cours du développement, Souris de lignée C57BL, Souris knockout.
English descriptors
- KwdEn :
- Animals, Animals, Newborn, Embryo, Mammalian (embryology), Embryo, Mammalian (metabolism), Gene Expression Regulation, Developmental, Immunohistochemistry, Lymphangiogenesis (genetics), Lymphatic System (embryology), Lymphatic System (metabolism), Lymphatic Vessels (embryology), Lymphatic Vessels (metabolism), Mice, Inbred C57BL, Mice, Knockout, Receptor, TIE-1 (genetics), Receptor, TIE-1 (metabolism), Reverse Transcriptase Polymerase Chain Reaction.
- MESH :
- chemical , genetics : Receptor, TIE-1.
- embryology : Embryo, Mammalian, Lymphatic System, Lymphatic Vessels.
- genetics : Lymphangiogenesis.
- metabolism : Embryo, Mammalian, Lymphatic System, Lymphatic Vessels, Receptor, TIE-1.
- Animals, Animals, Newborn, Gene Expression Regulation, Developmental, Immunohistochemistry, Mice, Inbred C57BL, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Tie1 is a receptor tyrosine kinase with broad expression in embryonic endothelium. Reduction of Tie1 levels in mouse embryos with a hypomorphic Tie1 allele resulted in abnormal lymphatic patterning and architecture, decreased lymphatic draining efficiency, and ultimately, embryonic demise. Here we report that Tie1 is present uniformly throughout the lymphatics and from late embryonic/early postnatal stages, becomes more restricted to lymphatic valve regions. To investigate later events of lymphatic development, we employed Cre-
Url:
DOI: 10.1016/j.ydbio.2014.12.021
PubMed: 25576926
PubMed Central: 4374493
Affiliations:
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Le document en format XML
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Scott Baldwin</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Pediatrics (Cardiology), Vanderbilt University Medical Center, Nashville, TN 37232, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Pediatrics (Cardiology), Vanderbilt University Medical Center, Nashville, TN 37232</wicri:regionArea><wicri:noRegion>TN 37232</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Cell and Development Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Cell and Development Biology, Vanderbilt University Medical Center, Nashville, TN 37232</wicri:regionArea><wicri:noRegion>TN 37232</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25576926</idno><idno type="pmc">4374493</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374493</idno><idno type="RBID">PMC:4374493</idno><idno type="doi">10.1016/j.ydbio.2014.12.021</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">003356</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003356</idno><idno type="wicri:Area/Pmc/Curation">003355</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003355</idno><idno type="wicri:Area/Pmc/Checkpoint">000D63</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D63</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001094</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001094</idno><idno type="wicri:Area/PubMed/Curation">001094</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001094</idno><idno type="wicri:Area/PubMed/Checkpoint">001094</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001094</idno><idno type="wicri:Area/Ncbi/Merge">006F18</idno><idno type="wicri:Area/Ncbi/Curation">006F18</idno><idno type="wicri:Area/Ncbi/Checkpoint">006F18</idno><idno type="wicri:doubleKey">0012-1606:2015:Qu X:tie:is:required</idno><idno type="wicri:Area/Main/Merge">001687</idno><idno type="wicri:Area/Main/Curation">001685</idno><idno type="wicri:Area/Main/Exploration">001685</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Tie1 is required for lymphatic valve and collecting vessel development</title><author><name sortKey="Qu, Xianghu" sort="Qu, Xianghu" uniqKey="Qu X" first="Xianghu" last="Qu">Xianghu Qu</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Pediatrics (Cardiology), Vanderbilt University Medical Center, Nashville, TN 37232, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Pediatrics (Cardiology), Vanderbilt University Medical Center, Nashville, TN 37232</wicri:regionArea><wicri:noRegion>TN 37232</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Bin" sort="Zhou, Bin" uniqKey="Zhou B" first="Bin" last="Zhou">Bin Zhou</name><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Genetics, Albert Einstein College of Medicine, NY 10461, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Genetics, Albert Einstein College of Medicine, NY 10461</wicri:regionArea><wicri:noRegion>NY 10461</wicri:noRegion></affiliation></author><author><name sortKey="Baldwin, H Scott" sort="Baldwin, H Scott" uniqKey="Baldwin H" first="H. Scott" last="Baldwin">H. Scott Baldwin</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Pediatrics (Cardiology), Vanderbilt University Medical Center, Nashville, TN 37232, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Pediatrics (Cardiology), Vanderbilt University Medical Center, Nashville, TN 37232</wicri:regionArea><wicri:noRegion>TN 37232</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Cell and Development Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea> Department of Cell and Development Biology, Vanderbilt University Medical Center, Nashville, TN 37232</wicri:regionArea><wicri:noRegion>TN 37232</wicri:noRegion></affiliation></author></analytic><series><title level="j">Developmental biology</title><idno type="ISSN">0012-1606</idno><idno type="eISSN">1095-564X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Animals, Newborn</term><term>Embryo, Mammalian (embryology)</term><term>Embryo, Mammalian (metabolism)</term><term>Gene Expression Regulation, Developmental</term><term>Immunohistochemistry</term><term>Lymphangiogenesis (genetics)</term><term>Lymphatic System (embryology)</term><term>Lymphatic System (metabolism)</term><term>Lymphatic Vessels (embryology)</term><term>Lymphatic Vessels (metabolism)</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Receptor, TIE-1 (genetics)</term><term>Receptor, TIE-1 (metabolism)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Animaux nouveau-nés</term><term>Embryon de mammifère (embryologie)</term><term>Embryon de mammifère (métabolisme)</term><term>Immunohistochimie</term><term>Lymphangiogenèse (génétique)</term><term>RT-PCR</term><term>Récepteur TIE-1 (génétique)</term><term>Récepteur TIE-1 (métabolisme)</term><term>Régulation de l'expression des gènes au cours du développement</term><term>Souris de lignée C57BL</term><term>Souris knockout</term><term>Système lymphatique (embryologie)</term><term>Système lymphatique (métabolisme)</term><term>Vaisseaux lymphatiques (embryologie)</term><term>Vaisseaux lymphatiques (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptor, TIE-1</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Embryon de mammifère</term><term>Système lymphatique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Embryo, Mammalian</term><term>Lymphatic System</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lymphangiogenesis</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Lymphangiogenèse</term><term>Récepteur TIE-1</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Embryo, Mammalian</term><term>Lymphatic System</term><term>Lymphatic Vessels</term><term>Receptor, TIE-1</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Embryon de mammifère</term><term>Récepteur TIE-1</term><term>Système lymphatique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Animals, Newborn</term><term>Gene Expression Regulation, Developmental</term><term>Immunohistochemistry</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Animaux nouveau-nés</term><term>Immunohistochimie</term><term>RT-PCR</term><term>Régulation de l'expression des gènes au cours du développement</term><term>Souris de lignée C57BL</term><term>Souris knockout</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Tie1 is a receptor tyrosine kinase with broad expression in embryonic endothelium. Reduction of Tie1 levels in mouse embryos with a hypomorphic Tie1 allele resulted in abnormal lymphatic patterning and architecture, decreased lymphatic draining efficiency, and ultimately, embryonic demise. Here we report that Tie1 is present uniformly throughout the lymphatics and from late embryonic/early postnatal stages, becomes more restricted to lymphatic valve regions. To investigate later events of lymphatic development, we employed Cre-<italic>loxP</italic> recombination utilizing a floxed <italic>Tie1</italic> allele and an <italic>Nfatc1Cre</italic> line, to provide <italic>loxP</italic> excision predominantly in lymphatic endothelium and developing valves. Interestingly, unlike the early prenatal defects previously described by ubiquitous endothelial deletion, excision of <italic>Tie1</italic> with <italic>Nfatc1Cre</italic> resulted in abnormal lymphatic defects in postnatal mice and was characterized by agenesis of lymphatic valves and a deficiency of collecting lymphatic vessels. Attenuation of Tie1 signaling in lymphatic endothelium prevented initiation of lymphatic valve specification by Prox1 high expression lymphatic endothelial cells that is associated with the onset of turbulent flow in the lymphatic circulation. Our findings reveal a fundamental role for Tie signaling during lymphatic vessel remodeling and valve morphogenesis and implicate it as a candidate gene involved in primary lymphedema.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Qu, Xianghu" sort="Qu, Xianghu" uniqKey="Qu X" first="Xianghu" last="Qu">Xianghu Qu</name></noRegion><name sortKey="Baldwin, H Scott" sort="Baldwin, H Scott" uniqKey="Baldwin H" first="H. Scott" last="Baldwin">H. Scott Baldwin</name><name sortKey="Baldwin, H Scott" sort="Baldwin, H Scott" uniqKey="Baldwin H" first="H. Scott" last="Baldwin">H. Scott Baldwin</name><name sortKey="Zhou, Bin" sort="Zhou, Bin" uniqKey="Zhou B" first="Bin" last="Zhou">Bin Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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