Tie1 is required for lymphatic valve and collecting vessel development
Identifieur interne : 006F18 ( Ncbi/Curation ); précédent : 006F17; suivant : 006F19Tie1 is required for lymphatic valve and collecting vessel development
Auteurs : Xianghu Qu [États-Unis] ; Bin Zhou [États-Unis] ; H. Scott Baldwin [États-Unis]Source :
- Developmental biology [ 0012-1606 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Animaux nouveau-nés, Embryon de mammifère (embryologie), Embryon de mammifère (métabolisme), Immunohistochimie, Lymphangiogenèse (génétique), RT-PCR, Récepteur TIE-1 (génétique), Récepteur TIE-1 (métabolisme), Régulation de l'expression des gènes au cours du développement, Souris de lignée C57BL, Souris knockout, Système lymphatique (embryologie), Système lymphatique (métabolisme), Vaisseaux lymphatiques (embryologie), Vaisseaux lymphatiques (métabolisme).
- MESH :
- embryologie : Embryon de mammifère, Système lymphatique, Vaisseaux lymphatiques.
- génétique : Lymphangiogenèse, Récepteur TIE-1.
- métabolisme : Embryon de mammifère, Récepteur TIE-1, Système lymphatique, Vaisseaux lymphatiques.
- Animaux, Animaux nouveau-nés, Immunohistochimie, RT-PCR, Régulation de l'expression des gènes au cours du développement, Souris de lignée C57BL, Souris knockout.
English descriptors
- KwdEn :
- Animals, Animals, Newborn, Embryo, Mammalian (embryology), Embryo, Mammalian (metabolism), Gene Expression Regulation, Developmental, Immunohistochemistry, Lymphangiogenesis (genetics), Lymphatic System (embryology), Lymphatic System (metabolism), Lymphatic Vessels (embryology), Lymphatic Vessels (metabolism), Mice, Inbred C57BL, Mice, Knockout, Receptor, TIE-1 (genetics), Receptor, TIE-1 (metabolism), Reverse Transcriptase Polymerase Chain Reaction.
- MESH :
- chemical , genetics : Receptor, TIE-1.
- embryology : Embryo, Mammalian, Lymphatic System, Lymphatic Vessels.
- genetics : Lymphangiogenesis.
- metabolism : Embryo, Mammalian, Lymphatic System, Lymphatic Vessels, Receptor, TIE-1.
- Animals, Animals, Newborn, Gene Expression Regulation, Developmental, Immunohistochemistry, Mice, Inbred C57BL, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Tie1 is a receptor tyrosine kinase with broad expression in embryonic endothelium. Reduction of Tie1 levels in mouse embryos with a hypomorphic Tie1 allele resulted in abnormal lymphatic patterning and architecture, decreased lymphatic draining efficiency, and ultimately, embryonic demise. Here we report that Tie1 is present uniformly throughout the lymphatics and from late embryonic/early postnatal stages, becomes more restricted to lymphatic valve regions. To investigate later events of lymphatic development, we employed Cre-
Url:
DOI: 10.1016/j.ydbio.2014.12.021
PubMed: 25576926
PubMed Central: 4374493
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PMC:4374493Le document en format XML
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<term>Animals, Newborn</term>
<term>Embryo, Mammalian (embryology)</term>
<term>Embryo, Mammalian (metabolism)</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Immunohistochemistry</term>
<term>Lymphangiogenesis (genetics)</term>
<term>Lymphatic System (embryology)</term>
<term>Lymphatic System (metabolism)</term>
<term>Lymphatic Vessels (embryology)</term>
<term>Lymphatic Vessels (metabolism)</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Receptor, TIE-1 (genetics)</term>
<term>Receptor, TIE-1 (metabolism)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<term>Animaux nouveau-nés</term>
<term>Embryon de mammifère (embryologie)</term>
<term>Embryon de mammifère (métabolisme)</term>
<term>Immunohistochimie</term>
<term>Lymphangiogenèse (génétique)</term>
<term>RT-PCR</term>
<term>Récepteur TIE-1 (génétique)</term>
<term>Récepteur TIE-1 (métabolisme)</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Système lymphatique (embryologie)</term>
<term>Système lymphatique (métabolisme)</term>
<term>Vaisseaux lymphatiques (embryologie)</term>
<term>Vaisseaux lymphatiques (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptor, TIE-1</term>
</keywords>
<keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Embryon de mammifère</term>
<term>Système lymphatique</term>
<term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Embryo, Mammalian</term>
<term>Lymphatic System</term>
<term>Lymphatic Vessels</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lymphangiogenesis</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Lymphangiogenèse</term>
<term>Récepteur TIE-1</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Embryo, Mammalian</term>
<term>Lymphatic System</term>
<term>Lymphatic Vessels</term>
<term>Receptor, TIE-1</term>
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<term>Récepteur TIE-1</term>
<term>Système lymphatique</term>
<term>Vaisseaux lymphatiques</term>
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<term>Animals, Newborn</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Immunohistochemistry</term>
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<term>Mice, Knockout</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<term>Animaux nouveau-nés</term>
<term>Immunohistochimie</term>
<term>RT-PCR</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">Tie1 is a receptor tyrosine kinase with broad expression in embryonic endothelium. Reduction of Tie1 levels in mouse embryos with a hypomorphic Tie1 allele resulted in abnormal lymphatic patterning and architecture, decreased lymphatic draining efficiency, and ultimately, embryonic demise. Here we report that Tie1 is present uniformly throughout the lymphatics and from late embryonic/early postnatal stages, becomes more restricted to lymphatic valve regions. To investigate later events of lymphatic development, we employed Cre-<italic>loxP</italic>
recombination utilizing a floxed <italic>Tie1</italic>
allele and an <italic>Nfatc1Cre</italic>
line, to provide <italic>loxP</italic>
excision predominantly in lymphatic endothelium and developing valves. Interestingly, unlike the early prenatal defects previously described by ubiquitous endothelial deletion, excision of <italic>Tie1</italic>
with <italic>Nfatc1Cre</italic>
resulted in abnormal lymphatic defects in postnatal mice and was characterized by agenesis of lymphatic valves and a deficiency of collecting lymphatic vessels. Attenuation of Tie1 signaling in lymphatic endothelium prevented initiation of lymphatic valve specification by Prox1 high expression lymphatic endothelial cells that is associated with the onset of turbulent flow in the lymphatic circulation. Our findings reveal a fundamental role for Tie signaling during lymphatic vessel remodeling and valve morphogenesis and implicate it as a candidate gene involved in primary lymphedema.</p>
</div>
</front>
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